AAB MT Hematology EXAM STUDY GUIDE
2026/2027 ACCURATE QUESTIONS WITH CORRECT
DETAILED ANSWERS || 100% GUARANTEED PASS
<NEWEST VERSION>
1. What is hemoglobin composed of? - ANSWER ✔ 4 heme, 4 iron, 4 globins
2. What disorder does a defect in heme synthesis lead to? - ANSWER ✔
Porphyria
3. Porphyria - ANSWER ✔ Deficiency in the enzymes of the porphyrin
pathway leads to insufficient production of heme. The principal problem in
these deficiencies is the accumulation of porphyrins, the heme precursors,
which are toxic to tissue in high concentrations.
4. What is methemoglobin? - ANSWER ✔ Methemoglobin is a form of
hemoglobin that contains ferric [Fe3+] iron and has a decreased ability to
bind oxygen. However, the ferric iron has an increased affinity for bound
oxygen. When methemoglobin concentration is elevated in red blood cells,
tissue hypoxia can occur.
5. What is the function of the enzyme methemoglobin-cytochrome C reductase
in a red blood cell? - ANSWER ✔ To keep iron in the ferrous state
6. Which one of the following is a characteristic of immature RBCs? -
ANSWER ✔ Presence of euchromatin
,7. Toxic granulation of neutrophils is usually associated with which one of the
following? - ANSWER ✔ Severe bacterial infections
8. Dohle bodies are found in the cytoplasm of which cells? - ANSWER ✔
Neutrophils
9. At what stage will specific (secondary) granules of polymorphonuclear cells
appear? - ANSWER ✔ Myelocytes
10.What is the immediate precursor of the band polymorphonuclear neutrophil?
- ANSWER ✔ Metamyelocyte
11.What WBC is least often seen on a normal peripheral smear? - ANSWER ✔
Basophil
12.What is the largest leukocyte seen on a normal peripheral blood smear? -
ANSWER ✔ Monocyte
13.Which laboratory procedure may be used to assist in differentiating CML
from a leukemoid reaction?
A. Absolute PLT count
B. Prussian Blue stain
C. LAP stain
D. Peroxidase Stain - ANSWER ✔ C. LAP stain
14.Diseases associated with a dysfunction of polymorphonuclear neutrophils
(PMNs) include all of the following with the exception of:
A. Chediak Higashi Syndrome
B. Chronic Granulomatous Dz
, C. Gaucher's Dz
D. Myeloperoxidase Deficiency - ANSWER ✔ C. Gaucher's disease
15.Clinically significant IgG antibodies - ANSWER ✔ Kell, Duffy, Kidd →
cause HDFN or transfusion reactions.
16.IgM antibodies - ANSWER ✔ Lewis, P, M/N → cold-reactive antibodies,
usually less severe.
17.Direct Antiglobulin Test (DAT) - ANSWER ✔ Detects IgG/complement on
RBCs (in vivo).
18.Indirect Antiglobulin Test (IAT) - ANSWER ✔ Detects antibodies in serum
(in vitro).
19.Crossmatching purpose - ANSWER ✔ Ensure compatibility; detect
antibodies before transfusion.
20.Rouleaux formation resolution - ANSWER ✔ Saline replacement technique.
21.Antibody titration in pregnancy - ANSWER ✔ Quantify maternal IgG
antibodies → assess risk for HDFN.
22.Fetal D+ cells detection - ANSWER ✔ Rosette test, Kleihauer-Betke stain,
or flow cytometry.
, 23.HDFN confirmation test - ANSWER ✔ DAT on neonatal RBCs, possibly
elution for antibody ID.
24.Urgent transfusion options - ANSWER ✔ Uncrossmatched O negative
RBCs; ABO incompatible only if necessary with monitoring.
25.Types of transfusion reactions - ANSWER ✔ Acute hemolytic, delayed
hemolytic, febrile non-hemolytic, allergic/anaphylactic.
26.Corrected Count Increment (CCI) - ANSWER ✔ Measures platelet
transfusion efficacy; low CCI → refractoriness.
27.Autologous donation - ANSWER ✔ Patient donates for self-use.
28.Directed donation - ANSWER ✔ Specific donor chosen for patient.
29.Proficiency testing - ANSWER ✔ Testing unknown external samples as if
patient samples → evaluates lab competency.
30.QC failure response - ANSWER ✔ Identify problem → Corrective action →
Document → Prevent recurrence.
31.What WBC inclusions are seen in both Wright's stain smears and Prussian
Blue stained smears? - ANSWER ✔ Pappenheimer bodies
32.Which Hgb is replaced by HgbH after birth in individuals with HbH dz?
2026/2027 ACCURATE QUESTIONS WITH CORRECT
DETAILED ANSWERS || 100% GUARANTEED PASS
<NEWEST VERSION>
1. What is hemoglobin composed of? - ANSWER ✔ 4 heme, 4 iron, 4 globins
2. What disorder does a defect in heme synthesis lead to? - ANSWER ✔
Porphyria
3. Porphyria - ANSWER ✔ Deficiency in the enzymes of the porphyrin
pathway leads to insufficient production of heme. The principal problem in
these deficiencies is the accumulation of porphyrins, the heme precursors,
which are toxic to tissue in high concentrations.
4. What is methemoglobin? - ANSWER ✔ Methemoglobin is a form of
hemoglobin that contains ferric [Fe3+] iron and has a decreased ability to
bind oxygen. However, the ferric iron has an increased affinity for bound
oxygen. When methemoglobin concentration is elevated in red blood cells,
tissue hypoxia can occur.
5. What is the function of the enzyme methemoglobin-cytochrome C reductase
in a red blood cell? - ANSWER ✔ To keep iron in the ferrous state
6. Which one of the following is a characteristic of immature RBCs? -
ANSWER ✔ Presence of euchromatin
,7. Toxic granulation of neutrophils is usually associated with which one of the
following? - ANSWER ✔ Severe bacterial infections
8. Dohle bodies are found in the cytoplasm of which cells? - ANSWER ✔
Neutrophils
9. At what stage will specific (secondary) granules of polymorphonuclear cells
appear? - ANSWER ✔ Myelocytes
10.What is the immediate precursor of the band polymorphonuclear neutrophil?
- ANSWER ✔ Metamyelocyte
11.What WBC is least often seen on a normal peripheral smear? - ANSWER ✔
Basophil
12.What is the largest leukocyte seen on a normal peripheral blood smear? -
ANSWER ✔ Monocyte
13.Which laboratory procedure may be used to assist in differentiating CML
from a leukemoid reaction?
A. Absolute PLT count
B. Prussian Blue stain
C. LAP stain
D. Peroxidase Stain - ANSWER ✔ C. LAP stain
14.Diseases associated with a dysfunction of polymorphonuclear neutrophils
(PMNs) include all of the following with the exception of:
A. Chediak Higashi Syndrome
B. Chronic Granulomatous Dz
, C. Gaucher's Dz
D. Myeloperoxidase Deficiency - ANSWER ✔ C. Gaucher's disease
15.Clinically significant IgG antibodies - ANSWER ✔ Kell, Duffy, Kidd →
cause HDFN or transfusion reactions.
16.IgM antibodies - ANSWER ✔ Lewis, P, M/N → cold-reactive antibodies,
usually less severe.
17.Direct Antiglobulin Test (DAT) - ANSWER ✔ Detects IgG/complement on
RBCs (in vivo).
18.Indirect Antiglobulin Test (IAT) - ANSWER ✔ Detects antibodies in serum
(in vitro).
19.Crossmatching purpose - ANSWER ✔ Ensure compatibility; detect
antibodies before transfusion.
20.Rouleaux formation resolution - ANSWER ✔ Saline replacement technique.
21.Antibody titration in pregnancy - ANSWER ✔ Quantify maternal IgG
antibodies → assess risk for HDFN.
22.Fetal D+ cells detection - ANSWER ✔ Rosette test, Kleihauer-Betke stain,
or flow cytometry.
, 23.HDFN confirmation test - ANSWER ✔ DAT on neonatal RBCs, possibly
elution for antibody ID.
24.Urgent transfusion options - ANSWER ✔ Uncrossmatched O negative
RBCs; ABO incompatible only if necessary with monitoring.
25.Types of transfusion reactions - ANSWER ✔ Acute hemolytic, delayed
hemolytic, febrile non-hemolytic, allergic/anaphylactic.
26.Corrected Count Increment (CCI) - ANSWER ✔ Measures platelet
transfusion efficacy; low CCI → refractoriness.
27.Autologous donation - ANSWER ✔ Patient donates for self-use.
28.Directed donation - ANSWER ✔ Specific donor chosen for patient.
29.Proficiency testing - ANSWER ✔ Testing unknown external samples as if
patient samples → evaluates lab competency.
30.QC failure response - ANSWER ✔ Identify problem → Corrective action →
Document → Prevent recurrence.
31.What WBC inclusions are seen in both Wright's stain smears and Prussian
Blue stained smears? - ANSWER ✔ Pappenheimer bodies
32.Which Hgb is replaced by HgbH after birth in individuals with HbH dz?
