CHEM 1005 EVALUATION EXAM ACTUAL QUESTIONS AND
SOLUTIONS GRADED A+
✔✔cobalamin supplementation would be the most appropriate in the case of which of
the following enzyme deficiencies? - ✔✔homocysteine methyltransferase
✔✔phenylketonuria can present due to a deficiency in which of the following required
metabolic factors? - ✔✔tetrahydrobiopterin (BH4)
✔✔ which of the following is the regulatory enzyme for fatty acid synthesis? - ✔✔acetyl
CoA carboxylase
✔✔an increase in the ratio of insulin to glucagon will increase the activity of which of the
following enzymes - ✔✔acetyl CoA carboxylase, phosphofructokinase 2, glycogen
synthase
✔✔insulin stimulates lipogenesis through several mechanisms. which of the following is
not an insulin-stimulated process that enhances lipogenesis? - ✔✔decreased activity of
the pyruvate dehydrogenase complex
✔✔during fatty acid synthesis, after the initial step involving acetyl-CoA, the fatty acid
chain is elongated by the addition of which of the following compounds? - ✔✔malonyl-
CoA
✔✔which of the following is the regulated step of lipogenesis in eukaryotes? -
✔✔carboxylation of acetyl-CoA
✔✔fatty acid synthase is a multimeric enzyme complex. which of the following subunits
contains pantothenic acid as a cofactor? - ✔✔acyl carrier protein (ACP)
✔✔an individual consumes a large meal consisting of a cheeseburger and fries. which
of the following intermediates is shuttled out of the TCA cycle to be used as a substrate
for fatty acid synthesis ? - ✔✔citrate
✔✔an increase in the ratio of insulin to glucagon leads to which of the following
metabolic shifts? - ✔✔acetyl-CoA carboxylase will become dephosphorylated and
active
✔✔a 45-year old man is found to have elevated serum triglycerides (>730 mg/dL). He
tells you he forgot to fast before his visit and ate a full breakfast of bacon and eggs
before the labs were drawn. Which of the following lipoproteins would be the largest
contributors to a measurements of plasma triglycerides in this situation? -
✔✔chylomicrons and VLDLs
, ✔✔The blood of a person who has recently consumed a large amount of fast would
most likely contain increased levels of which of the following? - ✔✔chylomicrons
✔✔what is the primary lipid component of a VLDL particle? - ✔✔triacylglycerols
✔✔which of the following lipoproteins would be the largest contributors to a
measurement of plasma cholesterol in an individual following a 2 hr fast? - ✔✔HDLs
and LDLs
✔✔nascent chylomicrons interact with HDL particles within circulation. Which of the
following Apo proteins is obtained from HDL during this interaction? - ✔✔ApoCII and
ApoE
✔✔the enzyme that catalyzes the hydrolysis of triacylglycerol from chylomicrons and
VLDL is: - ✔✔lipoprotein lipase
✔✔A 45 year old man is found to have elevated serum triglycerides of > 730mg/dL. He
tells you he fasted for 24 hours before his visit and only had water to drink. Which of the
following lipoproteins would be the largest contributors to a measurement of
triglycerides in this situation? - ✔✔VLDLs
✔✔which of the following is the regulatory enzyme in cholesterol synthesis? - ✔✔HMG-
CoA reductase
✔✔a patient's triglyceride levels are within normal limits, but their cholesterol is 350
mg/dL (normal 200 mg/dL). The physician prescribes medication for this patient, which
he states inhibits the enzyme HMG CoA reductase. The drug that was prescribed
lowers circulating levels of cholesterol by - ✔✔decreasing hepatic cholesterol
biosynthesis
✔✔cholesterol is a substrate for the synthesis of all of the following compounds except:
- ✔✔thyroid hormone
✔✔dietary cholesterol is primarily transported in the body by which of the following
lipoproteins? - ✔✔chylomicron
✔✔a deficiency in the LDL receptor will result in an initial decrease in which of the
following? - ✔✔intracellular cholesterol
✔✔cholesterol stimulates the activity of which of the following proteins required for bile
acid synthesis - ✔✔7 a-hydroxylase
SOLUTIONS GRADED A+
✔✔cobalamin supplementation would be the most appropriate in the case of which of
the following enzyme deficiencies? - ✔✔homocysteine methyltransferase
✔✔phenylketonuria can present due to a deficiency in which of the following required
metabolic factors? - ✔✔tetrahydrobiopterin (BH4)
✔✔ which of the following is the regulatory enzyme for fatty acid synthesis? - ✔✔acetyl
CoA carboxylase
✔✔an increase in the ratio of insulin to glucagon will increase the activity of which of the
following enzymes - ✔✔acetyl CoA carboxylase, phosphofructokinase 2, glycogen
synthase
✔✔insulin stimulates lipogenesis through several mechanisms. which of the following is
not an insulin-stimulated process that enhances lipogenesis? - ✔✔decreased activity of
the pyruvate dehydrogenase complex
✔✔during fatty acid synthesis, after the initial step involving acetyl-CoA, the fatty acid
chain is elongated by the addition of which of the following compounds? - ✔✔malonyl-
CoA
✔✔which of the following is the regulated step of lipogenesis in eukaryotes? -
✔✔carboxylation of acetyl-CoA
✔✔fatty acid synthase is a multimeric enzyme complex. which of the following subunits
contains pantothenic acid as a cofactor? - ✔✔acyl carrier protein (ACP)
✔✔an individual consumes a large meal consisting of a cheeseburger and fries. which
of the following intermediates is shuttled out of the TCA cycle to be used as a substrate
for fatty acid synthesis ? - ✔✔citrate
✔✔an increase in the ratio of insulin to glucagon leads to which of the following
metabolic shifts? - ✔✔acetyl-CoA carboxylase will become dephosphorylated and
active
✔✔a 45-year old man is found to have elevated serum triglycerides (>730 mg/dL). He
tells you he forgot to fast before his visit and ate a full breakfast of bacon and eggs
before the labs were drawn. Which of the following lipoproteins would be the largest
contributors to a measurements of plasma triglycerides in this situation? -
✔✔chylomicrons and VLDLs
, ✔✔The blood of a person who has recently consumed a large amount of fast would
most likely contain increased levels of which of the following? - ✔✔chylomicrons
✔✔what is the primary lipid component of a VLDL particle? - ✔✔triacylglycerols
✔✔which of the following lipoproteins would be the largest contributors to a
measurement of plasma cholesterol in an individual following a 2 hr fast? - ✔✔HDLs
and LDLs
✔✔nascent chylomicrons interact with HDL particles within circulation. Which of the
following Apo proteins is obtained from HDL during this interaction? - ✔✔ApoCII and
ApoE
✔✔the enzyme that catalyzes the hydrolysis of triacylglycerol from chylomicrons and
VLDL is: - ✔✔lipoprotein lipase
✔✔A 45 year old man is found to have elevated serum triglycerides of > 730mg/dL. He
tells you he fasted for 24 hours before his visit and only had water to drink. Which of the
following lipoproteins would be the largest contributors to a measurement of
triglycerides in this situation? - ✔✔VLDLs
✔✔which of the following is the regulatory enzyme in cholesterol synthesis? - ✔✔HMG-
CoA reductase
✔✔a patient's triglyceride levels are within normal limits, but their cholesterol is 350
mg/dL (normal 200 mg/dL). The physician prescribes medication for this patient, which
he states inhibits the enzyme HMG CoA reductase. The drug that was prescribed
lowers circulating levels of cholesterol by - ✔✔decreasing hepatic cholesterol
biosynthesis
✔✔cholesterol is a substrate for the synthesis of all of the following compounds except:
- ✔✔thyroid hormone
✔✔dietary cholesterol is primarily transported in the body by which of the following
lipoproteins? - ✔✔chylomicron
✔✔a deficiency in the LDL receptor will result in an initial decrease in which of the
following? - ✔✔intracellular cholesterol
✔✔cholesterol stimulates the activity of which of the following proteins required for bile
acid synthesis - ✔✔7 a-hydroxylase
