MARYVILLE PHARM EXAM 3 WITH
100% CORRECT ANSWERS 2026
Colchicine use correct answers >> Reduce incidence of acute
gout attacks
relieves pain and discomfort (although it is not an analgesic)
Colchicine Actions correct answers >> inhibits migration of
granulocytes to the inflamed areas
Reduces lactic acid production by granulocytes
decreases deposition of uric acid
interferes with kinin formation and reduces phagocytosis
Overall effect is it decreases the inflammatory response to urate
crystals
Colchicine cautions correct answers >> Renal Failure- not
effective in the presence of renal failure. Poorly excreted with RF.
Hepatic dysfunction- associated with hepatotoxicity
,Peptic ulcer disease or spastic colon- will worsen GI disturbances
Colchicine Adverse Effects correct answers >> Nausea,
vomiting, diarrhea, and abdominal pain
Malabsorption of vitamin B12
Elevated levels with RF may lead to myopathy, neuropathy, &
muscle weakness
Colchicine low dose therapy correct answers >> 1.2 mg
initial dose followed by 0.6 mg one hour later or 1.8 mg total.
High dose is a 4.8 mg total dose. High dose is no longer
recommended because low dose is just as effective with less side
effects.
Febuxostat Patient teaching correct answers >> Risk of Gout
flare up when just starting
Contraindicated in patients taking xanthine oxidase because of
increased risk of toxicity.
Corticosteroid Adverse effects when taken > 6 months correct
answers >> Adrenal Suppression
Osteoporosis- increased osteoclastic activity
Worsen Diabetic control
,May mask infections
Report Tarry black stools or abdominal pain
Colchicine Monitoring correct answers >> BUN, Creatinine,
Creatinine clearance, serum uric acid levels (goal is < 6).
Corticosteroid adverse effects correct answers >> Mask
infections
Exacerbation of fungal infections ( don't use)
HTN due to NA & H20 retention
Edema with renal disease
Osteoporosis
Altered glucose regulation in diabetics
Increased GI bleeding & perforation esp. with PUD and UC pts.
Altered growth & development in children
Skin thinning & atrophy
Alopecia
Poor wound healing
Myopathy
Truncal obesity, moon face & buffalo hump
Corticosteroid monitoring correct answers >> BP, glucose,
electrolytes, Bone Mineral Density, monitor for cataracts &
glaucoma
, Steroid psychosis correct answers >> Delirium, agitation,
insomnia, mood swings, severe depression
Reasons for steroid tapering correct answers >> Avoid
recurrence of underlying disease process
Gradually reverse adrenal suppression
NSAID Black Box warnings correct answers >> Increased risk
of cardiovascular thrombotic events
Increased risk of life threatening GI bleeding
Increased risk of MI and stroke (Risk increases with duration of
use)
NSAIDs Adverse effects correct answers >> GI bleeding, -
most common. Report black tarry stools or coffee ground emesis
(due to Cox 1 inhibition)
GI ulceration & perforation (Elderly pts. at greatest risk)
Skin rash, itching
MI & Stroke
100% CORRECT ANSWERS 2026
Colchicine use correct answers >> Reduce incidence of acute
gout attacks
relieves pain and discomfort (although it is not an analgesic)
Colchicine Actions correct answers >> inhibits migration of
granulocytes to the inflamed areas
Reduces lactic acid production by granulocytes
decreases deposition of uric acid
interferes with kinin formation and reduces phagocytosis
Overall effect is it decreases the inflammatory response to urate
crystals
Colchicine cautions correct answers >> Renal Failure- not
effective in the presence of renal failure. Poorly excreted with RF.
Hepatic dysfunction- associated with hepatotoxicity
,Peptic ulcer disease or spastic colon- will worsen GI disturbances
Colchicine Adverse Effects correct answers >> Nausea,
vomiting, diarrhea, and abdominal pain
Malabsorption of vitamin B12
Elevated levels with RF may lead to myopathy, neuropathy, &
muscle weakness
Colchicine low dose therapy correct answers >> 1.2 mg
initial dose followed by 0.6 mg one hour later or 1.8 mg total.
High dose is a 4.8 mg total dose. High dose is no longer
recommended because low dose is just as effective with less side
effects.
Febuxostat Patient teaching correct answers >> Risk of Gout
flare up when just starting
Contraindicated in patients taking xanthine oxidase because of
increased risk of toxicity.
Corticosteroid Adverse effects when taken > 6 months correct
answers >> Adrenal Suppression
Osteoporosis- increased osteoclastic activity
Worsen Diabetic control
,May mask infections
Report Tarry black stools or abdominal pain
Colchicine Monitoring correct answers >> BUN, Creatinine,
Creatinine clearance, serum uric acid levels (goal is < 6).
Corticosteroid adverse effects correct answers >> Mask
infections
Exacerbation of fungal infections ( don't use)
HTN due to NA & H20 retention
Edema with renal disease
Osteoporosis
Altered glucose regulation in diabetics
Increased GI bleeding & perforation esp. with PUD and UC pts.
Altered growth & development in children
Skin thinning & atrophy
Alopecia
Poor wound healing
Myopathy
Truncal obesity, moon face & buffalo hump
Corticosteroid monitoring correct answers >> BP, glucose,
electrolytes, Bone Mineral Density, monitor for cataracts &
glaucoma
, Steroid psychosis correct answers >> Delirium, agitation,
insomnia, mood swings, severe depression
Reasons for steroid tapering correct answers >> Avoid
recurrence of underlying disease process
Gradually reverse adrenal suppression
NSAID Black Box warnings correct answers >> Increased risk
of cardiovascular thrombotic events
Increased risk of life threatening GI bleeding
Increased risk of MI and stroke (Risk increases with duration of
use)
NSAIDs Adverse effects correct answers >> GI bleeding, -
most common. Report black tarry stools or coffee ground emesis
(due to Cox 1 inhibition)
GI ulceration & perforation (Elderly pts. at greatest risk)
Skin rash, itching
MI & Stroke
