Page 1 of 100
HESI A2 A&P EXAM LATEST UPDATE 2026-
2027 QUESTIONS AND DETAILED
SOLUTIONS
Question: The cheekbones are _________ to the nose.
A. anterior
B. proximal
C. deep
D. lateral - CORRECT ANSWER✔✔D. The cheeckbones are to the right and left of the nose,
meaning that they are lateral to it, or away from the body's midline.
Question: Which organ system is primarily responsible for generating antibodies?
A. The endocrine system
B. The digestive system
C. The lymphatic system
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D. The nervous system - CORRECT ANSWER✔✔C. Antibodies are formed when an antigen
stimulates B cells, special lymphocytes, to produce specialized proteins that combat foreign
substances or organisms.
Question: The lateral side of the right knee would be ______.
A. the kneecap.
B. closest to the left knee.
C. farthest from the left knee.
D. on the underside of the knee. - CORRECT ANSWER✔✔C. Something that is lateral is toward
the outer side of the body. The side of the right knee farthest from the left knee would fit this
description.
Question: In which part of the lungs do nearly all the gaseous exchanges between air and
blood take place?
A. Pleura.
B. Trachea.
C. Bronchioles.
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D. Alveoli. - CORRECT ANSWER✔✔D. The alveoli are the tiny air sacs in the lungs where the
exchange of oxygen and carbon dioxide takes place.
Question: How do the intercostal muscles between the ribs assist with respiration?
A. By protecting the delicate bronchioles and alveoli.
B. By signaling a decrease in intra-alveolar pressure.
C. By enlarging and reducing the space in the thorax.
D. By maintaining a medial separation between pleurae. - CORRECT ANSWER✔✔C. The ribs
themselves protect the lungs (choice A), but the intercostals are muscles that expand and
contract the chest, allowing it to draw in and expel air.
Question: In which organ do muscles push food into the stomach via peristalsis?
A. Mouth.
B. Small intestine.
C. Epiglottis.
D. Esophagus. - CORRECT ANSWER✔✔D. The esphagus connects the stomach and the oral
cavity in the human digestive system.
, Page 4 of 100
Question: For the average person, what is true about caloric intake?
A. It should increase with age after age 25.
B. It should decline with age after age 25.
C. It should remain constant over a lifetime.
D. It should decline and then increase with age. - CORRECT ANSWER✔✔B. The height of calorie
intake for healthy, active people is approximately their mid-20s. After that, calorie intake should
decline slightly as energy needs decline.
Q:Which is an anterior muscle?
A. Gluteus maximus
B. Quadriceps femoris
C. Biceps femoris
D. Adductor magnus - CORRECT ANSWER✔✔B. An anterior muscle is located near the front of
the body. Of those listed, the quadriceps( frontal thigh muscle) is the most anterior.
Question: How might the headrest on a car prevent traumatic injury?
A. By limiting hyperflexion of the neck
HESI A2 A&P EXAM LATEST UPDATE 2026-
2027 QUESTIONS AND DETAILED
SOLUTIONS
Question: The cheekbones are _________ to the nose.
A. anterior
B. proximal
C. deep
D. lateral - CORRECT ANSWER✔✔D. The cheeckbones are to the right and left of the nose,
meaning that they are lateral to it, or away from the body's midline.
Question: Which organ system is primarily responsible for generating antibodies?
A. The endocrine system
B. The digestive system
C. The lymphatic system
, Page 2 of 100
D. The nervous system - CORRECT ANSWER✔✔C. Antibodies are formed when an antigen
stimulates B cells, special lymphocytes, to produce specialized proteins that combat foreign
substances or organisms.
Question: The lateral side of the right knee would be ______.
A. the kneecap.
B. closest to the left knee.
C. farthest from the left knee.
D. on the underside of the knee. - CORRECT ANSWER✔✔C. Something that is lateral is toward
the outer side of the body. The side of the right knee farthest from the left knee would fit this
description.
Question: In which part of the lungs do nearly all the gaseous exchanges between air and
blood take place?
A. Pleura.
B. Trachea.
C. Bronchioles.
, Page 3 of 100
D. Alveoli. - CORRECT ANSWER✔✔D. The alveoli are the tiny air sacs in the lungs where the
exchange of oxygen and carbon dioxide takes place.
Question: How do the intercostal muscles between the ribs assist with respiration?
A. By protecting the delicate bronchioles and alveoli.
B. By signaling a decrease in intra-alveolar pressure.
C. By enlarging and reducing the space in the thorax.
D. By maintaining a medial separation between pleurae. - CORRECT ANSWER✔✔C. The ribs
themselves protect the lungs (choice A), but the intercostals are muscles that expand and
contract the chest, allowing it to draw in and expel air.
Question: In which organ do muscles push food into the stomach via peristalsis?
A. Mouth.
B. Small intestine.
C. Epiglottis.
D. Esophagus. - CORRECT ANSWER✔✔D. The esphagus connects the stomach and the oral
cavity in the human digestive system.
, Page 4 of 100
Question: For the average person, what is true about caloric intake?
A. It should increase with age after age 25.
B. It should decline with age after age 25.
C. It should remain constant over a lifetime.
D. It should decline and then increase with age. - CORRECT ANSWER✔✔B. The height of calorie
intake for healthy, active people is approximately their mid-20s. After that, calorie intake should
decline slightly as energy needs decline.
Q:Which is an anterior muscle?
A. Gluteus maximus
B. Quadriceps femoris
C. Biceps femoris
D. Adductor magnus - CORRECT ANSWER✔✔B. An anterior muscle is located near the front of
the body. Of those listed, the quadriceps( frontal thigh muscle) is the most anterior.
Question: How might the headrest on a car prevent traumatic injury?
A. By limiting hyperflexion of the neck
