NRNP 6675 FINAL EXAM LATEST
2025/2026 QUESTIONS WITH
RATIONALES
1. A 32-year-old female presents with persistent sadness, anhedonia, poor
concentration, and fatigue for 3 months. She denies manic symptoms. What is the
most likely diagnosis?
A. Bipolar II disorder
B. Major Depressive Disorder
C. Persistent depressive disorder
D. Adjustment disorder with depressed mood
Correct Answer: B
Rationale:
B is correct: Symptoms meet DSM-5-TR criteria for MDD (>2 weeks, functional
impairment, no mania).
A is incorrect: Requires hypomanic episodes.
C is incorrect: Requires ≥2 years of symptoms.
D is incorrect: Symptoms exceed expected response to a stressor.
2. First-line pharmacologic treatment for generalized anxiety disorder (GAD) is:
A. Benzodiazepines
B. SSRIs
C. Antipsychotics
D. Mood stabilizers
Correct Answer: B
Rationale:
,NRNP 6675 FINAL EXAM LATEST
2025/2026 QUESTIONS WITH
RATIONALES
B is correct: SSRIs are first-line due to safety and efficacy.
A is incorrect: Short-term use only; dependency risk.
C is incorrect: Not first-line for anxiety.
D is incorrect: Used for bipolar disorders.
3. Which antidepressant carries the highest risk of serotonin syndrome when
combined with other serotonergic drugs?
A. Fluoxetine
B. Sertraline
C. MAOIs
D. Bupropion
Correct Answer: C
Rationale:
C is correct: MAOIs inhibit monoamine breakdown → high serotonin levels.
A & B: SSRIs but safer than MAOIs.
D: Minimal serotonergic activity.
4. A patient on lithium develops tremors, confusion, and diarrhea. What is the
priority action?
A. Continue lithium
B. Add propranolol
C. Check lithium level and hold medication
D. Increase dose
Correct Answer: C
,NRNP 6675 FINAL EXAM LATEST
2025/2026 QUESTIONS WITH
RATIONALES
Rationale:
C is correct: Signs of lithium toxicity.
A & D worsen toxicity.
B treats tremor only, not toxicity.
5. Which medication requires regular monitoring of ANC?
A. Risperidone
B. Haloperidol
C. Clozapine
D. Quetiapine
Correct Answer: C
Rationale:
C is correct: Risk of agranulocytosis.
Others do not require ANC monitoring.
6. Which medication is first-line for social anxiety disorder?
A. Lithium
B. SSRIs
C. Antipsychotics
D. Mood stabilizers
Correct Answer: B
Why B is correct:
, NRNP 6675 FINAL EXAM LATEST
2025/2026 QUESTIONS WITH
RATIONALES
SSRIs reduce fear, avoidance, and performance anxiety.
Why others are incorrect:
A & D: Used for mood disorders.
C: Reserved for psychosis.
7. Which antidepressant causes the LEAST sexual dysfunction?
A. Fluoxetine
B. Bupropion
C. Paroxetine
D. Sertraline
Correct Answer: B
Why B is correct:
Bupropion has minimal sexual side effects.
Why others are incorrect:
A, C, D: SSRIs commonly cause sexual dysfunction.
8. Fear of embarrassment and scrutiny in social situations defines:
A. Panic disorder
B. Social anxiety disorder
2025/2026 QUESTIONS WITH
RATIONALES
1. A 32-year-old female presents with persistent sadness, anhedonia, poor
concentration, and fatigue for 3 months. She denies manic symptoms. What is the
most likely diagnosis?
A. Bipolar II disorder
B. Major Depressive Disorder
C. Persistent depressive disorder
D. Adjustment disorder with depressed mood
Correct Answer: B
Rationale:
B is correct: Symptoms meet DSM-5-TR criteria for MDD (>2 weeks, functional
impairment, no mania).
A is incorrect: Requires hypomanic episodes.
C is incorrect: Requires ≥2 years of symptoms.
D is incorrect: Symptoms exceed expected response to a stressor.
2. First-line pharmacologic treatment for generalized anxiety disorder (GAD) is:
A. Benzodiazepines
B. SSRIs
C. Antipsychotics
D. Mood stabilizers
Correct Answer: B
Rationale:
,NRNP 6675 FINAL EXAM LATEST
2025/2026 QUESTIONS WITH
RATIONALES
B is correct: SSRIs are first-line due to safety and efficacy.
A is incorrect: Short-term use only; dependency risk.
C is incorrect: Not first-line for anxiety.
D is incorrect: Used for bipolar disorders.
3. Which antidepressant carries the highest risk of serotonin syndrome when
combined with other serotonergic drugs?
A. Fluoxetine
B. Sertraline
C. MAOIs
D. Bupropion
Correct Answer: C
Rationale:
C is correct: MAOIs inhibit monoamine breakdown → high serotonin levels.
A & B: SSRIs but safer than MAOIs.
D: Minimal serotonergic activity.
4. A patient on lithium develops tremors, confusion, and diarrhea. What is the
priority action?
A. Continue lithium
B. Add propranolol
C. Check lithium level and hold medication
D. Increase dose
Correct Answer: C
,NRNP 6675 FINAL EXAM LATEST
2025/2026 QUESTIONS WITH
RATIONALES
Rationale:
C is correct: Signs of lithium toxicity.
A & D worsen toxicity.
B treats tremor only, not toxicity.
5. Which medication requires regular monitoring of ANC?
A. Risperidone
B. Haloperidol
C. Clozapine
D. Quetiapine
Correct Answer: C
Rationale:
C is correct: Risk of agranulocytosis.
Others do not require ANC monitoring.
6. Which medication is first-line for social anxiety disorder?
A. Lithium
B. SSRIs
C. Antipsychotics
D. Mood stabilizers
Correct Answer: B
Why B is correct:
, NRNP 6675 FINAL EXAM LATEST
2025/2026 QUESTIONS WITH
RATIONALES
SSRIs reduce fear, avoidance, and performance anxiety.
Why others are incorrect:
A & D: Used for mood disorders.
C: Reserved for psychosis.
7. Which antidepressant causes the LEAST sexual dysfunction?
A. Fluoxetine
B. Bupropion
C. Paroxetine
D. Sertraline
Correct Answer: B
Why B is correct:
Bupropion has minimal sexual side effects.
Why others are incorrect:
A, C, D: SSRIs commonly cause sexual dysfunction.
8. Fear of embarrassment and scrutiny in social situations defines:
A. Panic disorder
B. Social anxiety disorder
