2
PSY 520 Exam 3 with precise detailed || || || || || || ||
solutions
Considerations for post-bariatric surgery || || ||
- increased gastric pH
|| || ||
- Decreased SA
|| ||
- impact on ER agents
|| || || ||
Elixir, is it desirable vehicle?
|| || || ||
Not desirable vehicle or base for pediatric pts b/c of alcohol content
|| || || || || || || || || || ||
Levigating agent ||
used to moisten and soften a tablet to facilitate the prep of liquid, especially when a large number
|| || || || || || || || || || || || || || || || || ||
of tablets is required or if tablets are extremely difficult to crush
|| || || || || || || || || || ||
General compounding methods/steps
|| ||
Trituration=> Levigation => mix to final volume => package and store || || || || || || || || || ||
Extemporaneous formulations resources || ||
- primary literature
|| ||
- package insert
|| ||
,2
- drug monographs
|| ||
- ASHP extemporaneous formulations book
|| || || ||
Benefits of standardizing concentrations
|| || ||
-Increased patient safety || ||
-Decreased health costs || ||
-Simplified ordering ||
-Allows for premixing || ||
-Reduced operational variations || ||
What meds are generally unsuitable for crushing
|| || || || || || ||
Atypical dosage form (sublingual, lozenge/buccal tablet, effervescent)
|| || || || || ||
Pharmacokinetic (PK) alteration (ER, etc.) || || || ||
Irritant (Risedronate, Ganciclovir, Everolimus)
|| || ||
Exposure risk (NIOSH list of antineoplastic and other healthcare drugs in healthcare settings)
|| || || || || || || || || || || ||
Unpalatable
,2
examples of drug types of pk alterations || || || || || ||
Extended-release formulations ||
Delayed-release formulations ||
Increased exposure ||
Release in specific area of the GI tract
|| || || || || || ||
Enhanced drug-delivery system || ||
Which med types are NOT always a complete contraindication
|| || || || || || || ||
Exposure risk, unpalatable || ||
Do not crush resources
|| || ||
- Drug monographs
|| ||
- Primary literature and other references
|| || || || ||
- Drug manufacturer information request
|| || || ||
- Institute for Safe Medication Practices (ISMP) Oral Dosage Forms That Should Not Be Crushed
|| || || || || || || || || || || || || || ||
– “ISMP Do Not Crush List”, last updated 2018 → no longer updated :(
|| || || || || || || || || || || || ||
Risks and considerations of manipulation and extemporaneous prep
|| || || || || || ||
, 2
Enteral tube administration compatibility
|| || ||
Variable doses ||
Contamination
Mixing solution compatibility || ||
*T or F. A med that can be crushed is automatically compatible for enteral tube administration
|| || || || || || || || || || || || || || || ||
and/or with tube feedings || || ||
False. Is NOT automatically compatible
|| || || ||
With enteral tubes _________ prep are generally preferred
|| || || || || || ||
liquid preps ||
What can lead to variable doses
|| || || || ||
- Improper or variable technique could lead to under- or over-dosing
|| || || || || || || || || ||
- Fragment or powder loss when crushing/splitting
|| || || || || ||
- Uneven splitting
|| ||
- Over-the-counter equipment available for splitting/crushing
|| || || || ||
PSY 520 Exam 3 with precise detailed || || || || || || ||
solutions
Considerations for post-bariatric surgery || || ||
- increased gastric pH
|| || ||
- Decreased SA
|| ||
- impact on ER agents
|| || || ||
Elixir, is it desirable vehicle?
|| || || ||
Not desirable vehicle or base for pediatric pts b/c of alcohol content
|| || || || || || || || || || ||
Levigating agent ||
used to moisten and soften a tablet to facilitate the prep of liquid, especially when a large number
|| || || || || || || || || || || || || || || || || ||
of tablets is required or if tablets are extremely difficult to crush
|| || || || || || || || || || ||
General compounding methods/steps
|| ||
Trituration=> Levigation => mix to final volume => package and store || || || || || || || || || ||
Extemporaneous formulations resources || ||
- primary literature
|| ||
- package insert
|| ||
,2
- drug monographs
|| ||
- ASHP extemporaneous formulations book
|| || || ||
Benefits of standardizing concentrations
|| || ||
-Increased patient safety || ||
-Decreased health costs || ||
-Simplified ordering ||
-Allows for premixing || ||
-Reduced operational variations || ||
What meds are generally unsuitable for crushing
|| || || || || || ||
Atypical dosage form (sublingual, lozenge/buccal tablet, effervescent)
|| || || || || ||
Pharmacokinetic (PK) alteration (ER, etc.) || || || ||
Irritant (Risedronate, Ganciclovir, Everolimus)
|| || ||
Exposure risk (NIOSH list of antineoplastic and other healthcare drugs in healthcare settings)
|| || || || || || || || || || || ||
Unpalatable
,2
examples of drug types of pk alterations || || || || || ||
Extended-release formulations ||
Delayed-release formulations ||
Increased exposure ||
Release in specific area of the GI tract
|| || || || || || ||
Enhanced drug-delivery system || ||
Which med types are NOT always a complete contraindication
|| || || || || || || ||
Exposure risk, unpalatable || ||
Do not crush resources
|| || ||
- Drug monographs
|| ||
- Primary literature and other references
|| || || || ||
- Drug manufacturer information request
|| || || ||
- Institute for Safe Medication Practices (ISMP) Oral Dosage Forms That Should Not Be Crushed
|| || || || || || || || || || || || || || ||
– “ISMP Do Not Crush List”, last updated 2018 → no longer updated :(
|| || || || || || || || || || || || ||
Risks and considerations of manipulation and extemporaneous prep
|| || || || || || ||
, 2
Enteral tube administration compatibility
|| || ||
Variable doses ||
Contamination
Mixing solution compatibility || ||
*T or F. A med that can be crushed is automatically compatible for enteral tube administration
|| || || || || || || || || || || || || || || ||
and/or with tube feedings || || ||
False. Is NOT automatically compatible
|| || || ||
With enteral tubes _________ prep are generally preferred
|| || || || || || ||
liquid preps ||
What can lead to variable doses
|| || || || ||
- Improper or variable technique could lead to under- or over-dosing
|| || || || || || || || || ||
- Fragment or powder loss when crushing/splitting
|| || || || || ||
- Uneven splitting
|| ||
- Over-the-counter equipment available for splitting/crushing
|| || || || ||
