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ChapterV1:VPrinciplesVofVPharmacology
MultipleVChoice
1. refer(s)VtoVspecificVmolecularVchangesVthatVoccurVwhenVaVdrugVbindsVt
oVaVparticularVtargetVsiteVorVreceptor,Vwhile
areVtheVresultingVwidespreadValterationsVinVfunction.
a. DrugVaction;VtherapeuticVeffects
b. SideVeffects;VdrugVeffects
c. TherapeuticVeffects;VsideVeffects
d. DrugVaction;VdrugVeffects
Answer:Vd
TextbookVReference:VPharmacology:VTheVScienceVofVDrugVAction
2. AfterVdrugVadministrationVhasVoccurred,VtheVamountVofVdrugVinVtheVbloodVthatVi
sVfreeVtoVbindVatVspecificVtargetVsitesVisVreferredVtoVas
a. theVtherapeuticVdose.
b. first-passVeffects.
c. bioavailability.
d. ED50.
Answer:Vc
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
3. TheVspecificVmolecularVchangesVthatVoccurVwhenVaVdrugVbindsVtoVaVparticularVtar
getVsiteVorVreceptorVareVreferredVtoVas
a. drugVeffects.
b. drugVaction.
c. sideVeffects.
d. placeboVeffects.
Answer:Vb
TextbookVReference:VPharmacology:VTheVScienceVofVDrugVAction
4. WhichVofVtheVfollowingVisVnotVaVpossibleVexplanationVforVplaceboVeffects?
a. PavlovianVconditioning
b. GeneticVvariation
c. DrugVcompetition
d. ExpectationVofVoutcome
Answer:Vc
TextbookVReference:VPharmacology:VTheVScienceVofVDrugVAction
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5. The administrationVofVoxytocinVhasVbeenVproposedVasVaVtreatmentVforVautism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer:Vc
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
6. WhichVfactorVdoesVnotVaffectVtheVpharmacokineticsVofVaVdrug?
a. RouteVofVadministration
b. LipidVsolubility
c. DepotVbinding
d. DrugVaction
Answer:Vd
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
7. First-passVmetabolismVoccursVwhenVdrugsVareVtaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer:Va
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
8. TheVareaVpostremaVisVoneVareaVinVtheVbrainVwhereVthe isVnotVcomplete.
a. cerebrospinalVfluid
b. blood–brainVbarrier
c. choroidVplexus
d. phospholipidVmembrane
Answer:Vb
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
9. First-passVmetabolismVoccursVwithVorallyVadministeredVdrugsVbecause
a. theirVabsorptionVisVslowedVbyVfood.
b. drugsVabsorbedVintoVtheVbloodstreamVfromVtheVstomachVgoVtoVtheVliverVonVthe
VwayVtoVgeneralVcirculation.
c. drugsVmustVfirstVsurviveVtheVacidicVenvironmentVofVtheVstomach.
d. salivaryVenzymesVinVtheVmouthVbeginVtheVprocessVofVmetabolism.
Answer:Vb
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
10. ToxicVsubstancesVinVtheVbloodVtriggerVaVvomitingVresponseVbyVactivatingVthe
a. blood–brainVbarrier.
b. choroidVplexus.
c. areaVpostrema.
d. medianVeminence.
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Answer:Vc
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
11. DrugsVadministeredV_ haveVtheVmostVrapidVonsetVofVaction.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer:Vd
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
12. IonizationVofVaVdrugVdependsVonVthe ofVtheVsolutionVandVthe
ofVtheVdrug.
a. pH;VpKa
b. pKa;VpH
c. concentration;VlipidVsolubility
d. pH;Vconcentration
Answer:Va
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
13. TheVabsorptionVofVaVdrugVdependsVonVallVofVtheVfollowingVexcept
a. lipidVsolubility.
b. ionization.
c. bodyVtemperature.
d. theVconcentrationVofVtheVdrug.
Answer:Vc
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
14. DrugsVthatVare shouldVbeVavoidedVbyVwomenVofVchildbearingVage.
a. teratogenic
b. ableVtoVcrossVtheVplacentalVbarrier
c. psychoactive
d. highlyVlipid-soluble
Answer:Va
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
15. AgentsVthatVinduceVdevelopmentalVabnormalitiesVinVaVfetusVareVknownVas
a. psychoactiveVdrugs.
b. illicitVdrugs.
c. teratogens.
d. placentalVdrugs.
Answer:Vc
TextbookVReference:VPharmacokineticVFactorsVDeterminingVDrugVAction
16. DepotVbindingVisVsaidVtoVoccurVwhenVdrugs
a. bindVtoVtheirVtargetVsites.
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