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Chapter 1: Principles of Pharmacology
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MultipleMChoice
1. refer(s)MtoMspecificMmolecularMchangesMthatMoccurMwhenMaMdrugMbindsMtoMa
MparticularMtargetMsiteMorMreceptor,Mwhile
areMtheMresultingMwidespreadMalterationsMinMfunction.
a. DrugMaction;MtherapeuticMeffects
b. SideMeffects;MdrugMeffects
c. TherapeuticMeffects;MsideMeffects
d. DrugMaction;MdrugMeffects
Answer:Md
TextbookMReference:MPharmacology:MTheMScienceMofMDrugMAction
2. AfterMdrugMadministrationMhasMoccurred,MtheMamountMofMdrugMinMtheMbloodMthatMisMfr
eeMtoMbindMatMspecificMtargetMsitesMisMreferredMtoMas
a. theMtherapeuticMdose.
b. first-passMeffects.
c. bioavailability.
d. ED50.
Answer:Mc
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
3. TheMspecificMmolecularMchangesMthatMoccurMwhenMaMdrugMbindsMtoMaMparticularMtarget
MsiteMorMreceptorMareMreferredMtoMas
a. drugMeffects.
b. drugMaction.
c. sideMeffects.
d. placeboMeffects.
Answer:Mb
TextbookMReference:MPharmacology:MTheMScienceMofMDrugMAction
4. WhichMofMtheMfollowingMisMnotMaMpossibleMexplanationMforMplaceboMeffects?
a. PavlovianMconditioning
b. GeneticMvariation
c. DrugMcompetition
d. ExpectationMofMoutcome
Answer:Mc
TextbookMReference:MPharmacology:MTheMScienceMofMDrugMAction
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5. The administrationMofMoxytocinMhasMbeenMproposedMasMaMtreatmentMforMautism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer:Mc
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
6. WhichMfactorMdoesMnotMaffectMtheMpharmacokineticsMofMaMdrug?
a. RouteMofMadministration
b. LipidMsolubility
c. DepotMbinding
d. DrugMaction
Answer:Md
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
7. First-passMmetabolismMoccursMwhenMdrugsMareMtaken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer:Ma
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
8. TheMareaMpostremaMisMoneMareaMinMtheMbrainMwhereMthe isMnotMcomplete.
a. cerebrospinalMfluid
b. blood–brainMbarrier
c. choroidMplexus
d. phospholipidMmembrane
Answer:Mb
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
9. First-passMmetabolismMoccursMwithMorallyMadministeredMdrugsMbecause
a. theirMabsorptionMisMslowedMbyMfood.
b. drugsMabsorbedMintoMtheMbloodstreamMfromMtheMstomachMgoMtoMtheMliverMonMtheMwa
yMtoMgeneralMcirculation.
c. drugsMmustMfirstMsurviveMtheMacidicMenvironmentMofMtheMstomach.
d. salivaryMenzymesMinMtheMmouthMbeginMtheMprocessMofMmetabolism.
Answer:Mb
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
10. ToxicMsubstancesMinMtheMbloodMtriggerMaMvomitingMresponseMbyMactivatingMthe
a. blood–brainMbarrier.
b. choroidMplexus.
c. areaMpostrema.
d. medianMeminence.
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Answer:Mc
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
11. DrugsMadministeredM_ haveMtheMmostMrapidMonsetMofMaction.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer:Md
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
12. IonizationMofMaMdrugMdependsMonMthe ofMtheMsolutionMandMthe
ofMtheMdrug.
a. pH;MpKa
b. pKa;MpH
c. concentration;MlipidMsolubility
d. pH;Mconcentration
Answer:Ma
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
13. TheMabsorptionMofMaMdrugMdependsMonMallMofMtheMfollowingMexcept
a. lipidMsolubility.
b. ionization.
c. bodyMtemperature.
d. theMconcentrationMofMtheMdrug.
Answer:Mc
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
14. DrugsMthatMare shouldMbeMavoidedMbyMwomenMofMchildbearingMage.
a. teratogenic
b. ableMtoMcrossMtheMplacentalMbarrier
c. psychoactive
d. highlyMlipid-soluble
Answer:Ma
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
15. AgentsMthatMinduceMdevelopmentalMabnormalitiesMinMaMfetusMareMknownMas
a. psychoactiveMdrugs.
b. illicitMdrugs.
c. teratogens.
d. placentalMdrugs.
Answer:Mc
TextbookMReference:MPharmacokineticMFactorsMDeterminingMDrugMAction
16. DepotMbindingMisMsaidMtoMoccurMwhenMdrugs
a. bindMtoMtheirMtargetMsites.
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