Part 5 evolution of voltage-gated ion channels
The voltage-gated channel superfamily
Can look at how the voltage-gated ion channels have evolved by looking at the sequence
It is obvious that the 3 main types of voltage-gated ion channels are related in sequence and structure, which indicated
that they must have originated from a common ancestral gene/protein
The questions are:
1. How did we evolve?
2. When did they originate?
The simpler structure of voltage-gated potassium channels being comprised of 4 separate subunits, suggests that they
could resemble an ancestral channel that gave rist to the 4-domain sodium and calcium channels
Theoretical model of how a single-domain voltage-gated ion channel gene by 2 rounds on internal duplication
How could we test this model?
A gene encoding single domain protein giving rise to
The voltage-gated channel superfamily
Can look at how the voltage-gated ion channels have evolved by looking at the sequence
It is obvious that the 3 main types of voltage-gated ion channels are related in sequence and structure, which indicated
that they must have originated from a common ancestral gene/protein
The questions are:
1. How did we evolve?
2. When did they originate?
The simpler structure of voltage-gated potassium channels being comprised of 4 separate subunits, suggests that they
could resemble an ancestral channel that gave rist to the 4-domain sodium and calcium channels
Theoretical model of how a single-domain voltage-gated ion channel gene by 2 rounds on internal duplication
How could we test this model?
A gene encoding single domain protein giving rise to
