NURS 6521 FINAL EXAMS-& VERSIONS-700 Q &A-GRADUATION LEVEL-FULL SYLLABUSCOVERED-PRACTICE PAPER

NURS 6521 Advanced Pharmacology FINAL EXAM
700 Multiple Choice Questions & Answers
7 Exam Versions | Graduate Level | Guaranteed
Exam Preparation |Practice Question | High
Scorer |For Final Examination
MCQs 1–50 (with Correct Answers)
Pharmacokinetics & Pharmacodynamics

Q1. Bioavailability refers to:
A. Rate of drug elimination
B. Fraction of drug reaching systemic circulation
C. Drug distribution to tissues
D. Drug half-life
✅ Ans: B

Q2. First-pass metabolism mainly occurs in the:
A. Kidney
B. Lung
C. Liver
D. Heart
✅ Ans: C

Q3. A drug with high protein binding will have:
A. Increased free drug
B. Decreased duration
C. Less free circulating drug
D. Faster elimination
✅ Ans: C

Q4. Half-life of a drug is defined as the time required to:
A. Absorb half the dose
B. Eliminate half the drug concentration
C. Reach peak level
D. Metabolize the drug
✅ Ans: B

Q5. Which factor most affects drug clearance?
A. Age
B. Gender
C. Renal function
D. Route of administration
✅ Ans: C

,Q6. An agonist produces its effect by:
A. Blocking receptors
B. Activating receptors
C. Destroying receptors
D. Inhibiting enzymes
✅ Ans: B

Q7. A competitive antagonist:
A. Irreversibly binds
B. Competes for same receptor
C. Activates receptor
D. Has intrinsic activity
✅ Ans: B

Q8. Which route avoids first-pass metabolism?
A. Oral
B. Rectal
C. Sublingual
D. Gastric
✅ Ans: C

Q9. Volume of distribution indicates:
A. Drug absorption
B. Drug metabolism
C. Extent of tissue distribution
D. Drug elimination
✅ Ans: C

Q10. Cytochrome P450 enzymes are primarily involved in:
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
✅ Ans: C



Autonomic Nervous System

Q11. Parasympathetic activation causes:
A. Increased heart rate
B. Bronchodilation
C. Decreased heart rate
D. Pupil dilation
✅ Ans: C

Q12. Acetylcholine primarily acts on:
A. Alpha receptors
B. Beta receptors
C. Muscarinic receptors

,D. Dopamine receptors
✅ Ans: C

Q13. Beta-1 receptor stimulation results in:
A. Bronchodilation
B. Vasodilation
C. Increased heart rate
D. Decreased BP
✅ Ans: C

Q14. Which drug is a beta-blocker?
A. Albuterol
B. Propranolol
C. Epinephrine
D. Dopamine
✅ Ans: B

Q15. Anticholinergic drugs commonly cause:
A. Diarrhea
B. Bradycardia
C. Dry mouth
D. Bronchoconstriction
✅ Ans: C



Cardiovascular Pharmacology

Q16. ACE inhibitors reduce blood pressure by:
A. Increasing sodium retention
B. Blocking angiotensin II
C. Increasing heart rate
D. Increasing aldosterone
✅ Ans: B

Q17. Common side effect of ACE inhibitors:
A. Hypokalemia
B. Dry cough
C. Bradycardia
D. Weight gain
✅ Ans: B

Q18. Calcium channel blockers primarily affect:
A. Kidneys
B. Liver
C. Heart and vessels
D. Lungs
✅ Ans: C

, Q19. Loop diuretics act on which part of nephron?
A. Distal tubule
B. Proximal tubule
C. Loop of Henle
D. Collecting duct
✅ Ans: C

Q20. Digoxin toxicity is increased with:
A. Hyperkalemia
B. Hypokalemia
C. Hypernatremia
D. Hypercalcemia
✅ Ans: B



Endocrine & Diabetes

Q21. Insulin primarily lowers blood glucose by:
A. Increasing gluconeogenesis
B. Increasing glucose uptake
C. Decreasing glycogen synthesis
D. Blocking insulin receptors
✅ Ans: B

Q22. Metformin works mainly by:
A. Increasing insulin secretion
B. Decreasing hepatic glucose production
C. Increasing fat breakdown
D. Stimulating beta cells
✅ Ans: B

Q23. Hypoglycemia is most commonly caused by:
A. Overeating
B. Excess insulin
C. Infection
D. Stress
✅ Ans: B

Q24. Long-term corticosteroid use can cause:
A. Hypotension
B. Osteoporosis
C. Weight loss
D. Hypoglycemia
✅ Ans: B

Q25. Thyroid hormone increases:
A. Metabolic rate
B. Weight gain
C. Bradycardia