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MED2107 CNS drugs (5) Questions and
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Sedative-Hypnotics
Antiseizure Drugs
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Local Anesthetics
Drugs used in Parkinsonism & movement disorders Antipsychotics &
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Bipolar disorder agents Antidepressants
Opioid analgesics & antagonists Ans: CNS drugs
Inhibitory Ans: Receptor mechanisms for glycine and opioid peptides
Glutamic acid, GABA Ans: ... is the most important excitatory transmitter
in the CNS while ... is the primary inhibitory neurotransmitter
Sedative Ans: Drugs that relieve anxiety
Hypnotics Ans: Drugs that encourage sleep
Sedative-hypnotics Ans: Drugs that relieve anxiety or encourage sleep
Z (eszopiclone, zaleplon, zolpidem) Ans: Drugs that starts with "..." are
sedative-hypnotics
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GABA Ans: What appears to interact at two sites between alpha and
beta subunits
benzodiazepines, zolpidem, benzodiazepine, flumazenil, zolpidem Ans:
Binding of ... and ... occurs at a single site between alpha and gamma
(Y) subunits, facilitating the process of chloride ion channel opening. The
... antagonist ... also binds at this site and can reverse the hypnotic
effects of ...
alpha (a) , gamma (Y) Ans: Binding of benzodiazepines and the newer
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hypnotic drugs such as zolpidem occurs at a single site between ... and
... subunits, facilitating the process of chloride ion channel opening. The
benzodiazepine antagonist flumazenil also binds at this site and can
reverse the hypnotic effects of zolpidem.
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Different Ans: The binding sites of barbiturates are same / different from
that of benzodiazepines, zolpidem and flumazenil
inhibition in the CNS , benzodiazepines Ans: GABA is the transmitter most
associated with ... and the GABAa receptor mediates this effect. Binding
of ... facilitates the inhibitory actions of GABA, which are exerted through
increased chloride ion conductance
Benzodiazepines Ans: ... increase the frequency of GABA-mediated
chloride ion channel opening
frequency Ans: Benzodiazepines increase the... of GABA-mediated
chloride ion channel opening
zepam Ans: Benzodiazepines drugs end with "..."