AAB MT Hematology
1. What is hemoglobin composed of?
A. 4 heme, 4 iron, 4 globins
B. 4 heme, 4 iron, 1 globin
C. 2 heme, 2 iron, 2 globins
D. 1 heme, 1 iron, 1 globin: A. 4 heme, 4 iron, 4 globins
2. What disorder does a defect in heme synthesis lead to?
A. hemoglobinopathy
B. coagulopathy
C. thalassemia
D. porphyria: D. porphyria
3. What is the function of the enzyme methemoglobin-cytochrome C
reductase in red blood cell?
A. to keep iron in the ferric state
B. to keep iron in the ferrous state
C. to maintain an anaerobic pathway for glycolysis
D. to maintain an aerobic pathway for the Krebs cycle: B. to keep iron in the ferrous state
4. Which hemoglobin has a 200 times greater binding capacity for the
hemoglobin molecule than oxygen?
A. carboxyhemoglobin
B. oxyhemoglobin
C. sulfhemoglobin
D. methemoglobin: A. carboxyhemoglobin
5. What product is formed when ferrous iron of hemoglobin is oxidized to the
ferric state?
,A. sulfhemoglobin
B. methemoglobin
C. carboxyhemoglobin
D. cyanmethemoglobin: B. methemoglobin
6. Which hemoglobin derivative causes irreversible changes in the red
blood cells?
A. sulfhemoglobin
B. methemoglobin
C. carboxyhemoglobin
D. cyanmethemoglobin: A. sulfhemoglobin
7. Which of the following hemoglobin is NOT normally present in a normal
adult?
A. Hb-A1
B. Hb-A
C. Hb-S
D. Hb-F: C. Hb-S
8. Which embryonic hemoglobin is normally found in newborns?
A. Hb-F
B. Hb-Gower1
C. Hb-Gower2
D. Hb-Portland: A. Hb-F
9. What is the most abundant hemoglobin in a newborn?
A. Hb-Gower
B. Hb-A1
C. Hb-A2
D. Hb-F: D. Hb-F
10. What is the molecular structure of hemoglobin S?
, .
A. valine replaces glutamic acid in the 6th position of the beta chain
B. lysine replaces glutamic acid in the 6th position of the beta chain
C. lysine replaces glutamine in the 26th position of the beta chain
D. valine replaces glutamine in the 26th position of the beta chain: A. valine replaces
glutamic acid in the 6th position of the beta chain
11 Which of the following hemoglobin is insoluble under lowered oxygen
tension?
A. Hb-A
B. Hb-S
C. Hb-C
D. Hb-F: B. Hb-S
12. What laboratory test is used to confirm the specific diagnosis of sickle cell
anemia?
A. solubility test
B. sodium metabisulfite test
C. hemoglobin electrophoresis
D. presence of sickle cells in the peripheral smear: C. hemoglobin electrophoresis
13. In the solubility test for hemoglobin S, what is the reagent responsible for
the reduction of the hemoglobin molecule??
A. saponin
B. sodium dithionite
C. sodium hydroxide
D. ammonium sulfate: B. sodium dithionite
14. In hemoglobin C, what replace glutamic acid?
A. lysine
B. valine
, C. cystine
D. arginine: A. lysine
15. Which red blood cell inclusion is characteristic of hemoglobin C disease?
A. Cabot rings
B. Heinz bodies
C. basophilic stippling
D. rod-shaped crystals: D. rod-shaped crystals
1. What is hemoglobin composed of?
A. 4 heme, 4 iron, 4 globins
B. 4 heme, 4 iron, 1 globin
C. 2 heme, 2 iron, 2 globins
D. 1 heme, 1 iron, 1 globin: A. 4 heme, 4 iron, 4 globins
2. What disorder does a defect in heme synthesis lead to?
A. hemoglobinopathy
B. coagulopathy
C. thalassemia
D. porphyria: D. porphyria
3. What is the function of the enzyme methemoglobin-cytochrome C
reductase in red blood cell?
A. to keep iron in the ferric state
B. to keep iron in the ferrous state
C. to maintain an anaerobic pathway for glycolysis
D. to maintain an aerobic pathway for the Krebs cycle: B. to keep iron in the ferrous state
4. Which hemoglobin has a 200 times greater binding capacity for the
hemoglobin molecule than oxygen?
A. carboxyhemoglobin
B. oxyhemoglobin
C. sulfhemoglobin
D. methemoglobin: A. carboxyhemoglobin
5. What product is formed when ferrous iron of hemoglobin is oxidized to the
ferric state?
,A. sulfhemoglobin
B. methemoglobin
C. carboxyhemoglobin
D. cyanmethemoglobin: B. methemoglobin
6. Which hemoglobin derivative causes irreversible changes in the red
blood cells?
A. sulfhemoglobin
B. methemoglobin
C. carboxyhemoglobin
D. cyanmethemoglobin: A. sulfhemoglobin
7. Which of the following hemoglobin is NOT normally present in a normal
adult?
A. Hb-A1
B. Hb-A
C. Hb-S
D. Hb-F: C. Hb-S
8. Which embryonic hemoglobin is normally found in newborns?
A. Hb-F
B. Hb-Gower1
C. Hb-Gower2
D. Hb-Portland: A. Hb-F
9. What is the most abundant hemoglobin in a newborn?
A. Hb-Gower
B. Hb-A1
C. Hb-A2
D. Hb-F: D. Hb-F
10. What is the molecular structure of hemoglobin S?
, .
A. valine replaces glutamic acid in the 6th position of the beta chain
B. lysine replaces glutamic acid in the 6th position of the beta chain
C. lysine replaces glutamine in the 26th position of the beta chain
D. valine replaces glutamine in the 26th position of the beta chain: A. valine replaces
glutamic acid in the 6th position of the beta chain
11 Which of the following hemoglobin is insoluble under lowered oxygen
tension?
A. Hb-A
B. Hb-S
C. Hb-C
D. Hb-F: B. Hb-S
12. What laboratory test is used to confirm the specific diagnosis of sickle cell
anemia?
A. solubility test
B. sodium metabisulfite test
C. hemoglobin electrophoresis
D. presence of sickle cells in the peripheral smear: C. hemoglobin electrophoresis
13. In the solubility test for hemoglobin S, what is the reagent responsible for
the reduction of the hemoglobin molecule??
A. saponin
B. sodium dithionite
C. sodium hydroxide
D. ammonium sulfate: B. sodium dithionite
14. In hemoglobin C, what replace glutamic acid?
A. lysine
B. valine
, C. cystine
D. arginine: A. lysine
15. Which red blood cell inclusion is characteristic of hemoglobin C disease?
A. Cabot rings
B. Heinz bodies
C. basophilic stippling
D. rod-shaped crystals: D. rod-shaped crystals
