SOLUTIONS GRADED A+
◉ In the pregnant woman with asthma, in what part of her pregnancy are
symptoms and bronchospasm likely to worsen?
15-23 weeks
24-33 weeks
29-36 weeks. Answer: Correct answer is: 29-36 weeks.
General Feedback:
Bronchospasm can be triggered as a consequence of increased external
pressure on the smooth muscle of the bronchial structures. The
increasing size of the fetus during weeks 29-36 creates significant
displacement of abdominal and thoracic structures and places external
pressures on the bronchi. In the last four weeks, as the fetus "drops" into
the pelvis, pressure on the bronchi is actually relieved a bit and
symptoms often improve.
◉ Medications most commonly pass through the placenta via:
Facilitated transport
,Passive diffusion
Capillary pump action. Answer: General Feedback:
The placenta is freely permeable and most medications that are
administered to the mother just pass through the placenta along their
concentration gradient until a steady state is achieved (i.e., passive
diffusion). Facilitated transport and mechanical carrier state are
mechanisms by which a medication requires another compound to allow
the drug to pass through the membrane barrier. Pump actions are
required when a medication or other compound is being actively
pumped across a membrane against its concentration gradient.
◉ When treating a woman with a UTI who is 22-weeks pregnant, the NP
prescribes:
Nitrofurantoin
Ciprofloxacin
Azithromycin. Answer: Correct answer is: Nitrofurantoin.
General Feedback:
In both the pregnant and non-pregnant woman, E. coli is the most
common cause of uncomplicated UTI. Nitrofurantoin is a recommended
first-line agent during pregnancy (pregnancy category B). Azithromycin
is not recommended for UTIs, and the use of ciprofloxacin (pregnancy
,category C) should be limited given trends of increasing resistance by E.
coli and the availability of a safer alternative during pregnancy.
◉ In treating a pregnant woman with acute bacterial rhinosinusitis, the
NP would likely avoid prescribing:
Amoxicillin
Azithromycin
Levofloxacin. Answer: Correct answer is: Levofloxacin.
General Feedback:
Amoxicillin and azithromycin are both indicated for acute bacterial
rhinosinusitis (ABRS) and are pregnancy category B. While
levofloxacin is indicated for ABRS in certain circumstances,
levofloxacin is not indicated as a first-line agent in the otherwise healthy
patient. Additionally, levofloxacin is pregnancy category C and would
not be used when safer, effective alternatives are available.
◉ The recommended duration of antimicrobial therapy for treatment of
a urinary tract infection in a pregnant woman is:
3 days
5 days
, 7 days. Answer: Correct answer is: 7 days.
General Feedback:
UTIs are common during pregnancy and the most common causative
pathogen is Escherichia coli. In pregnancy, hormonal changes and
dilation of the renal pelvis actually favor ascension into the upper
urinary tract and, therefore, UTI is treated aggressively. Because of the
dangers of maternal and fetal complications from a UTI during
pregnancy, a 7-day regimen of antimicrobial therapy is recommended to
ensure eradication of the bacteria.
◉ The most likely causative organism in uncomplicated UTI during
pregnancy is:
Klebsiella spp
Proteus mirabilis
E. coli. Answer: Correct answer is: E. coli.
General Feedback:
In both the pregnant and non-pregnant woman, E. coli is the most
common cause of uncomplicated UTI. The organism is a common
intestinal inhabitant and the close proximity of the anus and urethra puts
women at risk for ascension of the organism into the lower urinary tract.