VSIM Christopher Parrish – Cystic Fibrosis EXAM
TEST QUESTIONS AND CORRECT ANSWERS
(VERIFIED ANSWERS) PLUS RATIONALES 2026
|INSTANT DOWNLOAD PDF
1. What is the primary genetic cause of cystic fibrosis?
A. Autosomal dominant mutation
B. Mutation in the CFTR gene
C. Mitochondrial DNA mutation
D. Chromosomal translocation
Correct Answer: B. Mutation in the CFTR gene
Rationale: Cystic fibrosis is caused by mutations in the CFTR
(cystic fibrosis transmembrane conductance regulator) gene,
which affects chloride ion transport across epithelial cells.
2. Which of the following is a common respiratory
manifestation of cystic fibrosis?
A. Chronic cough with thick mucus
B. Bronchiectasis
C. Frequent lung infections
D. Pulmonary embolism
Correct Answer: A, B, C
Rationale: CF patients often present with chronic productive
cough, bronchiectasis due to airway damage, and recurrent
,respiratory infections. Pulmonary embolism is not a typical CF
manifestation.
3. What digestive issue is commonly seen in CF patients?
A. Malabsorption
B. Pancreatic insufficiency
C. Acid reflux
D. Gallstones
Correct Answer: A, B
Rationale: CF can cause thick secretions that block pancreatic
ducts, leading to pancreatic insufficiency and malabsorption of
nutrients.
4. Which electrolyte imbalance is often observed in CF
patients?
A. Hyperkalemia
B. Hyponatremia
C. Hypernatremia
D. Hypocalcemia
Correct Answer: B
Rationale: CF patients can lose excessive salt in sweat, leading
to hyponatremia, especially during hot weather or exercise.
,5. What is the most common pulmonary pathogen in CF
patients during adolescence?
A. Staphylococcus aureus
B. Pseudomonas aeruginosa
C. Haemophilus influenzae
D. Streptococcus pneumoniae
Correct Answer: B
Rationale: Pseudomonas aeruginosa is the most common
chronic infection in older children and adults with CF, often
leading to worsening lung function.
6. Which of the following are clinical signs of CF in infants?
A. Meconium ileus
B. Failure to thrive
C. Diarrhea
D. Cyanosis
Correct Answer: A, B
Rationale: Meconium ileus is often an early sign of CF in
newborns, and poor weight gain occurs due to malabsorption.
7. Which diagnostic test is considered the gold standard for
CF?
A. Chest X-ray
B. Sweat chloride test
, C. Genetic testing for CFTR mutation
D. Pulmonary function test
Correct Answer: B
Rationale: The sweat chloride test is the standard diagnostic
test for CF; elevated chloride levels (>60 mmol/L) confirm the
diagnosis.
8. What type of inheritance pattern does CF follow?
A. Autosomal dominant
B. Autosomal recessive
C. X-linked recessive
D. Mitochondrial
Correct Answer: B
Rationale: CF is inherited in an autosomal recessive pattern,
meaning a child must inherit two defective CFTR genes to
manifest the disease.
9. Which of the following interventions help manage
respiratory symptoms in CF?
A. Chest physiotherapy
B. Inhaled bronchodilators
C. High-dose corticosteroids
D. Antibiotic therapy
Correct Answer: A, B, D
Rationale: Chest physiotherapy clears mucus, bronchodilators
TEST QUESTIONS AND CORRECT ANSWERS
(VERIFIED ANSWERS) PLUS RATIONALES 2026
|INSTANT DOWNLOAD PDF
1. What is the primary genetic cause of cystic fibrosis?
A. Autosomal dominant mutation
B. Mutation in the CFTR gene
C. Mitochondrial DNA mutation
D. Chromosomal translocation
Correct Answer: B. Mutation in the CFTR gene
Rationale: Cystic fibrosis is caused by mutations in the CFTR
(cystic fibrosis transmembrane conductance regulator) gene,
which affects chloride ion transport across epithelial cells.
2. Which of the following is a common respiratory
manifestation of cystic fibrosis?
A. Chronic cough with thick mucus
B. Bronchiectasis
C. Frequent lung infections
D. Pulmonary embolism
Correct Answer: A, B, C
Rationale: CF patients often present with chronic productive
cough, bronchiectasis due to airway damage, and recurrent
,respiratory infections. Pulmonary embolism is not a typical CF
manifestation.
3. What digestive issue is commonly seen in CF patients?
A. Malabsorption
B. Pancreatic insufficiency
C. Acid reflux
D. Gallstones
Correct Answer: A, B
Rationale: CF can cause thick secretions that block pancreatic
ducts, leading to pancreatic insufficiency and malabsorption of
nutrients.
4. Which electrolyte imbalance is often observed in CF
patients?
A. Hyperkalemia
B. Hyponatremia
C. Hypernatremia
D. Hypocalcemia
Correct Answer: B
Rationale: CF patients can lose excessive salt in sweat, leading
to hyponatremia, especially during hot weather or exercise.
,5. What is the most common pulmonary pathogen in CF
patients during adolescence?
A. Staphylococcus aureus
B. Pseudomonas aeruginosa
C. Haemophilus influenzae
D. Streptococcus pneumoniae
Correct Answer: B
Rationale: Pseudomonas aeruginosa is the most common
chronic infection in older children and adults with CF, often
leading to worsening lung function.
6. Which of the following are clinical signs of CF in infants?
A. Meconium ileus
B. Failure to thrive
C. Diarrhea
D. Cyanosis
Correct Answer: A, B
Rationale: Meconium ileus is often an early sign of CF in
newborns, and poor weight gain occurs due to malabsorption.
7. Which diagnostic test is considered the gold standard for
CF?
A. Chest X-ray
B. Sweat chloride test
, C. Genetic testing for CFTR mutation
D. Pulmonary function test
Correct Answer: B
Rationale: The sweat chloride test is the standard diagnostic
test for CF; elevated chloride levels (>60 mmol/L) confirm the
diagnosis.
8. What type of inheritance pattern does CF follow?
A. Autosomal dominant
B. Autosomal recessive
C. X-linked recessive
D. Mitochondrial
Correct Answer: B
Rationale: CF is inherited in an autosomal recessive pattern,
meaning a child must inherit two defective CFTR genes to
manifest the disease.
9. Which of the following interventions help manage
respiratory symptoms in CF?
A. Chest physiotherapy
B. Inhaled bronchodilators
C. High-dose corticosteroids
D. Antibiotic therapy
Correct Answer: A, B, D
Rationale: Chest physiotherapy clears mucus, bronchodilators
