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Test Bank for Harrison’s Principles of Internal Medicine 22nd edition | Vol. 1 22nd Edition | Internal Medicine | 2026 update | Chapter 1-66

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This document contains a comprehensive test bank based on Harrison’s Principles of Internal Medicine, 22nd Edition, covering chapter 1-66 of Volume 1 . with hundreds of high-yield multiple-choice questions and detailed rationales. It systematically follows the official Harrison’s chapter structure, including evidence-based medicine, preventive care, clinical decision-making, vaccine hesitancy, and core internal medicine topics, making it ideal for exam preparation and self-assessment. The material is well-suited for medical students, residents, and healthcare professionals preparing for internal medicine exams, USMLE-style questions, or in-depth revision of Harrison’s key concepts.

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Test Bank for Harrison’s Principles of Internal Medicine, 22nd
Edition. Volume 1

Dan Longo, Anthony Fauci, Dennis Kasper, Stephen Hauser, J. Larry Jameson, Joseph
Loscalzo, Steven Holland, Carol Langford

,Table of Contents
Part 1: The Profession of Medicine ................................................................................. 5
Chapter 1: The Practice of Medicine ........................................................................ 5
Chapter 2: Promoting Good Health ........................................................................ 42
Chapter 3: Vaccine Opposition and Hesitancy ....................................................... 70
Chapter 4: Decision-Making in Clinical Medicine ................................................... 87
Chapter 5: Precision Medicine and Clinical Care ................................................. 104
Chapter 6: Screening and Prevention of Disease ................................................ 121
Chapter 7: The Safety and Quality of Health Care ............................................... 138
Chapter 8: The Value of the Physical Examination in Modern Medicine .............. 155
Chapter 9: Physician Well-Being .......................................................................... 172
Chapter 10: Diagnosis: Reducing Errors and Improving Quality .......................... 189
Chapter 11: Racial and Ethnic Disparities in Health Care .................................... 206
Chapter 12: Ethical Issues in Clinical Medicine .................................................... 223
Chapter 13: Palliative and End-of-Life Care ......................................................... 240
Part 2 Cardinal Manifestations and Presentation of Diseases ..................................... 257
Section 1 Pain.......................................................................................................... 257
Chapter 14: Pain: Pathophysiology and Management ......................................... 257
Chapter 15: Chest Discomfort .............................................................................. 274
Chapter 16: Abdominal Pain ................................................................................ 290
Chapter 17: Headache ......................................................................................... 307
Chapter 18: Low Back Pain .................................................................................. 324
Chapter 19: Neck Pain ......................................................................................... 341
Section 2 Alterations in Body Temperature .............................................................. 358
Chapter 20: Fever ................................................................................................ 358
Chapter 21: Fever and Rash ................................................................................ 375
Chapter 22: Fever of Unknown Origin (FUO) ....................................................... 392
Section 3 Nervous System Dysfunction ................................................................... 408
Chapter 23: Syncope ........................................................................................... 408

, Chapter 24: Dizziness and Vertigo

............................................................................................................................. 424
Chapter 25: Fatigue ............................................................................................. 439
Chapter 26: Neurologic Causes of Weakness and Paralysis ............................... 454
Chapter 27: Numbness, Tingling, and Sensory Loss ........................................... 469
Chapter 28: Gait Disorders, Imbalance, and Falls................................................ 484
Chapter 29: Confusion and Delirium .................................................................... 500
Chapter 30: Coma ................................................................................................ 516
Chapter 31: Dementia

............................................................................................................................. 532
Chapter 32: Aphasia, Memory Loss, and Other Cognitive Disorders ................... 548
Chapter 33: Sleep Disorders ................................................................................ 564
Section 4 Disorders of Eyes, Ears, Nose, and Throat .............................................. 580
Chapter 34: Disorders of the Eye ......................................................................... 580
Chapter 35: Disorders of Smell and Taste

............................................................................................................................. 596
Chapter 36: Disorders of Hearing......................................................................... 612
Chapter 37: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms,
and Sore Throat ................................................................................................... 628
Chapter 38: Oral Manifestations of Disease

............................................................................................................................. 644
Section 5 Alterations in Circulatory and Respiratory Functions ............................... 660
Chapter 39: Dyspnea ........................................................................................... 660
Chapter 40: Cough ............................................................................................... 676
Chapter 41: Hemoptysis....................................................................................... 692
Chapter 42: Hypoxia and Cyanosis ...................................................................... 708
Chapter 43: Edema .............................................................................................. 724
Chapter 44: Approach to the Patient with a Heart Murmur ................................... 740
Chapter 45: Palpitations ....................................................................................... 756

, Chapter 46: Exercise Intolerance ......................................................................... 772
Section 6 Alterations in Gastrointestinal Function .................................................... 788
Chapter 47: Dysphagia ........................................................................................ 788
Chapter 48: Nausea, Vomiting, and Indigestion ................................................... 804
Chapter 49: Diarrhea and Constipation ................................................................ 820
Chapter 50: Unintentional Weight Loss ................................................................ 836
Chapter 51: Gastrointestinal Bleeding.................................................................. 852
Chapter 52: Jaundice ........................................................................................... 867
Chapter 53: Abdominal Swelling and Ascites ....................................................... 882
Section 7 Alterations in Renal and Urinary Tract Function ....................................... 897
Chapter 54: Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS). ..................... 897
Chapter 55: Azotemia and Urinary Abnormalities ................................................. 906
Chapter 56: Fluid and Electrolyte Disturbances ................................................... 915
Chapter 57: Hypercalcemia and Hypocalcemia ................................................... 924
Chapter 58: Acidosis and Alkalosis ...................................................................... 934
Section 8 Alterations in the Skin .............................................................................. 944
Chapter 59: Approach to the Patient with a Skin Disorder ................................... 944
Chapter 60: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common
Skin Disorders ...................................................................................................... 954
Chapter 61: Skin Manifestations of Internal Disease ............................................ 964
Chapter 62: Immunologically Mediated Skin Diseases ........................................ 974
Chapter 63: Cutaneous Drug Reactions .............................................................. 984
Chapter 64: Photosensitivity and Other Reactions to Sunlight ............................. 994
Chapter 65: Interpreting Peripheral Blood Smears ............................................. 1004
Chapter 66: Anemia and Polycythemia .............................................................. 1014

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