COSTCO ILE 3 CERTIFICATION TEST 2026
QUESTIONS WITH CORRECT ANSWERS
◉ II. Answer: biopharm class ___ has a low solubility and a high
permeability
◉ III. Answer: biopharm class ___ has a high solubility and a low
permeability
◉ IV. Answer: biopharm class ___ has a low solubility and a low
permeability
◉ metoprolol. Answer: example from class of drug in biopharm class
I
◉ carbamazepine. Answer: example from class of drug in biopharm
class II
◉ metformin. Answer: example from class of drug in biopharm class
III
◉ hydrochlorthiazide. Answer: example from class of drug in
biopharm class IV
,◉ 250. Answer: the difference between high and low solubility of
drugs per the biopharm class system is what mL?
◉ increase. Answer: ionization (increased water solubility), small
particle size, and amorphous particles ___ dissolution
◉ excipients. Answer: what factor can increase or decrease
dissolution?
◉ increase. Answer: Per the Noyes-Whitney Equation, temperature
can ___ dissolution rate
◉ decrease. Answer: Per the Noyes-Whitney Equation, viscosity can
___ dissolution rate
◉ decrease. Answer: Per the Noyes-Whitney Equation, gastric pH
can
◉ biggest. Answer: solubility and MW have the __ effect on
dissolution rate per the NW equation
◉ negative. Answer: polar, non-ionizable functional groups have a
___ logP
,◉ positive. Answer: non-polar function groups have a ___ logP
◉ non-polar. Answer: ring structures are ___ (polar or non-polar)
◉ do not. Answer: amides, phenols, ethers, alcohols, and ketones are
polar functional groups that do/do not ionize?
◉ do. Answer: amines, carboxylic acids, and amino acids are polar
functional groups that do/do not ionize?
◉ hydrophilic. Answer: negative logP scores are considered more
hydrophilic OR lipophilic?
◉ lipophilic. Answer: positive logP scores are considered more
hydrophilic OR lipophilic?
◉ hydrophilic. Answer: which type of molecules are more readily
disolved?
◉ lipophilic. Answer: which type of molecules more readily pass
through membranes?
, ◉ bases. Answer: what ionizes at pH of 3 or less?
◉ acids and bases. Answer: what ionizes at a pH between 6 and 8?
◉ acids. Answer: what ionizes at a pH above 10?
◉ pH=pKa+log[base]/[acid]. Answer: Henderson-Hassleback
Equation
◉ A-/HA. Answer: acid [base]/[acid]
◉ B/HB+. Answer: base [base]/[acid]
◉ anions. Answer: acids ionize to ___
◉ cations. Answer: bases ionize to ___
◉ absorption. Answer: size, polarity, and structure are the three
factors affecting ___
◉ passive. Answer: paracellular transport is a ___ transport that only
allows small, low MW, polar molecules to move across membranes
QUESTIONS WITH CORRECT ANSWERS
◉ II. Answer: biopharm class ___ has a low solubility and a high
permeability
◉ III. Answer: biopharm class ___ has a high solubility and a low
permeability
◉ IV. Answer: biopharm class ___ has a low solubility and a low
permeability
◉ metoprolol. Answer: example from class of drug in biopharm class
I
◉ carbamazepine. Answer: example from class of drug in biopharm
class II
◉ metformin. Answer: example from class of drug in biopharm class
III
◉ hydrochlorthiazide. Answer: example from class of drug in
biopharm class IV
,◉ 250. Answer: the difference between high and low solubility of
drugs per the biopharm class system is what mL?
◉ increase. Answer: ionization (increased water solubility), small
particle size, and amorphous particles ___ dissolution
◉ excipients. Answer: what factor can increase or decrease
dissolution?
◉ increase. Answer: Per the Noyes-Whitney Equation, temperature
can ___ dissolution rate
◉ decrease. Answer: Per the Noyes-Whitney Equation, viscosity can
___ dissolution rate
◉ decrease. Answer: Per the Noyes-Whitney Equation, gastric pH
can
◉ biggest. Answer: solubility and MW have the __ effect on
dissolution rate per the NW equation
◉ negative. Answer: polar, non-ionizable functional groups have a
___ logP
,◉ positive. Answer: non-polar function groups have a ___ logP
◉ non-polar. Answer: ring structures are ___ (polar or non-polar)
◉ do not. Answer: amides, phenols, ethers, alcohols, and ketones are
polar functional groups that do/do not ionize?
◉ do. Answer: amines, carboxylic acids, and amino acids are polar
functional groups that do/do not ionize?
◉ hydrophilic. Answer: negative logP scores are considered more
hydrophilic OR lipophilic?
◉ lipophilic. Answer: positive logP scores are considered more
hydrophilic OR lipophilic?
◉ hydrophilic. Answer: which type of molecules are more readily
disolved?
◉ lipophilic. Answer: which type of molecules more readily pass
through membranes?
, ◉ bases. Answer: what ionizes at pH of 3 or less?
◉ acids and bases. Answer: what ionizes at a pH between 6 and 8?
◉ acids. Answer: what ionizes at a pH above 10?
◉ pH=pKa+log[base]/[acid]. Answer: Henderson-Hassleback
Equation
◉ A-/HA. Answer: acid [base]/[acid]
◉ B/HB+. Answer: base [base]/[acid]
◉ anions. Answer: acids ionize to ___
◉ cations. Answer: bases ionize to ___
◉ absorption. Answer: size, polarity, and structure are the three
factors affecting ___
◉ passive. Answer: paracellular transport is a ___ transport that only
allows small, low MW, polar molecules to move across membranes
