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Exam (elaborations)

PCB 3233 IMMUNOLOGY EXAM 4

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PCB 3233 IMMUNOLOGY EXAM 4

Institution
PCB 3233 Immunology
Course
PCB 3233 Immunology

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PCB 3233 IMMUNOLOGY EXAM 4



Positive0Selection0-0ans✔makes0sure0that0your0T-Cell0recognizes0one0of0your0MHC.

If0it0does0not,0then0apoptosis

Negative0Selection0-
0ans✔Makes0sure0it0does0not0recognize0your0peptide:MHC0too0strongly


Does0gamma:0delta0T-cells0have0to0go0through0positive0selection?0-0ans✔No

What0does0turning0off0RAG01&20do0to0your0gene0rearrangement?0-
0ans✔Preserve0the0current0rearrangement


Primary0Lymphoid0Tissue0-0ans✔bone0marrow0and0thymus

What0does0TH10cells0do?0-0ans✔Activate0macrophages

Thymal0Stromal0Cells0-0ans✔Keeps0BCR0genes0closed0and0opens0TCR0genes

IgM0activates?0-0ans✔complement

Notch-10-0ans✔The0signal0for0survival.0It0drives0the0cell0on0the0T-cell0path0—
0signals0to0open0up0T-cell0rearrangement.


Signaling0rearrangement0keeps0T-cel0on0T-cell0pathway

Where0does0Maturation0and0Positive0Selection0occur?0-0ans✔Cortex0of0the0thymus

Can0negative0selection0also0take0place0in0the0Cortex?0-
0ans✔Yes,0negative0selection0can0take0place0in0the0cortex0at0the0same0time0as0positiv
e0selection

Where0does0negative0selection0take0place?0-0ans✔medulla0of0thymus

Where0are0mature0thymocytes0located?0-0ans✔Medulla

Where0are0immature0thymocytes0located?0-0ans✔Cortex

, What0special0cells0are0in0the0Medulla0-
0ans✔Dendritic0cells,0macrophages,0and0medullary0epithelial0cells


What0special0cells0are0in0the0cortex?0-0ans✔Cortical0epithelial0cells0and0macrophages

Where0can0you0find0AIRE?0-0ans✔in0the0medullary0epithelial0cells

AIRE0-0ans✔Autoimmune0regulator

made0by0medullary0epithelial0cells

Creates0a0couple0hundred0peripheral0peptides0that0can0be0used0to0test0T-
cells0for0negative0selection

DiGeorge's0syndrome0-
0ans✔deletion0in0chromosome0220in0which0thymus0fails0to0develop0and0T-
cells0are0absent

Hassall's0corpuscles0-
0ans✔macrophages0in0both0cortex0and0medulla0remove0the0many0thymocytes0that0fail
0to0mature0properly


Involution0of0the0Thymus0-
0ans✔Progressively0shrinks,0fat0gradually0claiming0areas0once0packed0with0thymocyte
s

-reduces0production0of0new0T-cells

Double0negative0-0ans✔No0CD40and0CD8

Double0Positive0-0ans✔CD40and0CD80are0present

Single0Positive0-0ans✔has0either0CD40or0CD8

CD20and0CD50-
0ans✔perform0adhesion0and0signaling.0They0are0present0during0double0negative0stage


Thymocytes0rearrange0which030genes0at0the0same0time?0-
0ans✔Beta,0gamma,0and0delta


pTalpha0-
0ans✔surrogate0alpha0chain.0signals0cell0to0halt0gamma,0delta,0Beta0chains,0gene0rear
rangement0and0begin0proliferation.

What0do0macrophages0do0in0the0thymus?0-0ans✔continually0remove0dead0cells
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