What are the indications for bariatric surgery? - Answers - BMI 40+, or more than 100 lbs
overweight
- BMI 35+ and at least one or more obesity related comorbidity
- Inability to achieve a healthy weight loss sustained for a period of time with prior weight loss
efforts
What are the obesity related comorbidities? - Answers T2DM, HTN, sleep apnea, asthma, non-
alcoholic fatty liver disease, osteoarthritis, lipid abnormalities, GI disorders, heart disease
What is considered the normal gastric pH? - Answers ~ 2-3
Where do bile salts enter and what do they help with? - Answers Enter at duodenum and can aid
in absorption as well as dissolution of hydrophobic drugs
Many drugs are absorbed to a greater degree in what area? - Answers Proximal small intestine
(duodenum / jejunum)
Is the absorptive surface large or small? - Answers Large
What is the normal intestinal transit time? - Answers Normally 1-2 hours, but can vary
Where do the common intestinal transporters and enzymes sit? - Answers - CYP3A4 →
duodenum/jejunum
- P-GP → ileum > duodenum
- Active transporters → duodenum/jejunum
How much is the stomach reduced in a sleeve gastrectomy? - Answers 15-25%
What type of procedure is a sleeve gastrectomy? - Answers Restrictive
What is maintained in a sleeve gastrectomy? - Answers Pylorus valve and small intestine
continuity
What is historically the most common weight loss procedure? - Answers Roux-en-Y gastric
bypass
What gastric pouch size does a Roux-en-Y gastric bypass yield? - Answers 15-20 mL
What type of procedure is a Roux-en-Y gastric bypass? - Answers Restrictive and malabsorptive
Are duodenal and jejunal continuity maintained in a Roux-en-Y gastric bypass? - Answers No
How much of the duodenum/jejunum serve as the biliopancreatic limb after a RYGB? - Answers