COMLEX Level 2 Rapid Review.
Newest 2026-2027. Questions &
Correct Answers. Graded A
5 W's of Postop Fever - ANS1. Wind - atelectasis, days 1-2
2. Water - UTI, days 3-5
3. Walking - DVT or PE days 4-6
4. Wound - infection days 6-7
5. Wonder drug - drug reaction, days 7-10
50-60yo pt with clear yellow nipple exudate, and nipple pain and burning,
with scaly raw lesion of nipple/areola - ANSPaget's dz of breast. Pt requires
thorough breast exam and bilateral mammography to rule out underlying
malignancy (common, usually ductal carcinoma in situ)
Addison's disease - ANSAdrenal insufficiency (aldosterone and cortisol def)
Hypotension, hyperpigmentations
Dec Na, inc K
African American male with HIV cc edema, SOB, weight loss, elevated
creatinine, proteinuria - ANSFocal segmental glomerulosclerosis
Commonly causes nephrotic syndrome in pts with HIV
1
,Alpha-1-antitrypsin deficiency - ANSAlpha 1 antitrypsin breaks down
neutophil elastase. Deficiency causes increased elasase > uncontrolled
elastin breakdown in lungs > panacinar emphysema. Can cause pulmonary
HTN > cor pulmonale.
Pts may also have cirrhosis > jaundice, elevated LFTs
.
Alpha-synuclein aggregates - ANSLewy bodies
Apgar scoring system - ANSColor: 2 for completely pink
Heart rate: 2 for >100bpm
Reflex Irritability: 2 for crying w/ limb withdrawl
Muscle Tone: 2 for active motion
Respiration: 2 for good strong cry
Aspirin-exacerbated respiratory disease (AERD) - ANSPseudo allergic rxn
to COX-1 inhibitor in patient who have chronic asthma and rhinosinusitis
with nasal polyps.
Sxs: flushing, congestion, rhinorrhea, periorbital edema.
B-pleated sheets resistant to proteases - ANSPrions, Creutzfeldt-Jakob
disease
Blood pressure requirement for tPA administration - ANS< 185/110
2
, Bulemia nervosa tx - ANSFluoxetine (long half-life). DO NOT GIVE
BUPROPION (lowers seizure threshold).
Note: Dx - binge/purge must occur 1x/wk for 3 months
CADASIL - ANSNOTCH3, 19p, AD
cerebral autosomal dominant arteriopathy with sucortical infarcts and
leukoencephalopathy. Leads to vascular dementia
Cancer of the distal 1/3 of the esophagus - ANSAdenocarcinoma of the
esophagus (more common in the US)
Cancer of the proximal 2/3 of the esophagus - ANSSquamous cell
carcinoma
Cause of DVT in pregnancy - ANSResistance to activated protein C after
the first trimester.
Protein C inactivates Factors V and VIII
CD4:CD8 ratio in AIDs pts - ANSless than 1 (HIV targets CD4 T cells,
which are normally more abundant than CD8 cells
Charcot's Triad - ANSFever, RUQ pain, jaundice.
Diagnostic for ascending cholangitis.
Add altered mental status and hypotension for Reynold's Pentad.
May also see dilated common bile duct on US or CT.
Charcot's triad - ANSRUQ pain, jaundice, fever
3
Newest 2026-2027. Questions &
Correct Answers. Graded A
5 W's of Postop Fever - ANS1. Wind - atelectasis, days 1-2
2. Water - UTI, days 3-5
3. Walking - DVT or PE days 4-6
4. Wound - infection days 6-7
5. Wonder drug - drug reaction, days 7-10
50-60yo pt with clear yellow nipple exudate, and nipple pain and burning,
with scaly raw lesion of nipple/areola - ANSPaget's dz of breast. Pt requires
thorough breast exam and bilateral mammography to rule out underlying
malignancy (common, usually ductal carcinoma in situ)
Addison's disease - ANSAdrenal insufficiency (aldosterone and cortisol def)
Hypotension, hyperpigmentations
Dec Na, inc K
African American male with HIV cc edema, SOB, weight loss, elevated
creatinine, proteinuria - ANSFocal segmental glomerulosclerosis
Commonly causes nephrotic syndrome in pts with HIV
1
,Alpha-1-antitrypsin deficiency - ANSAlpha 1 antitrypsin breaks down
neutophil elastase. Deficiency causes increased elasase > uncontrolled
elastin breakdown in lungs > panacinar emphysema. Can cause pulmonary
HTN > cor pulmonale.
Pts may also have cirrhosis > jaundice, elevated LFTs
.
Alpha-synuclein aggregates - ANSLewy bodies
Apgar scoring system - ANSColor: 2 for completely pink
Heart rate: 2 for >100bpm
Reflex Irritability: 2 for crying w/ limb withdrawl
Muscle Tone: 2 for active motion
Respiration: 2 for good strong cry
Aspirin-exacerbated respiratory disease (AERD) - ANSPseudo allergic rxn
to COX-1 inhibitor in patient who have chronic asthma and rhinosinusitis
with nasal polyps.
Sxs: flushing, congestion, rhinorrhea, periorbital edema.
B-pleated sheets resistant to proteases - ANSPrions, Creutzfeldt-Jakob
disease
Blood pressure requirement for tPA administration - ANS< 185/110
2
, Bulemia nervosa tx - ANSFluoxetine (long half-life). DO NOT GIVE
BUPROPION (lowers seizure threshold).
Note: Dx - binge/purge must occur 1x/wk for 3 months
CADASIL - ANSNOTCH3, 19p, AD
cerebral autosomal dominant arteriopathy with sucortical infarcts and
leukoencephalopathy. Leads to vascular dementia
Cancer of the distal 1/3 of the esophagus - ANSAdenocarcinoma of the
esophagus (more common in the US)
Cancer of the proximal 2/3 of the esophagus - ANSSquamous cell
carcinoma
Cause of DVT in pregnancy - ANSResistance to activated protein C after
the first trimester.
Protein C inactivates Factors V and VIII
CD4:CD8 ratio in AIDs pts - ANSless than 1 (HIV targets CD4 T cells,
which are normally more abundant than CD8 cells
Charcot's Triad - ANSFever, RUQ pain, jaundice.
Diagnostic for ascending cholangitis.
Add altered mental status and hypotension for Reynold's Pentad.
May also see dilated common bile duct on US or CT.
Charcot's triad - ANSRUQ pain, jaundice, fever
3
