,
,Chapter 2: Review of Basic Principles of Pharmacology
1. A patient’s nutritional intake and lab work reflects hypoalbuminemia. This is critical to
prescribing because:
A. Distribution of drugs to target tissue may be affected
2. Drugs that have a significant first-pass effect:
C. Are rapidly metabolized by the liver and may have little if any desired action
3. The route of excretion of a volatile drug will likely be:
B. The lungs
4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir of
the drug. Storage reservoirs:
C. Increase the length of time a drug is available and active
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
B. Biological half-life
6. Azithromycin dosing requires the first day’s dose be twice those of the other 4 days of
the prescription. This is considered a loading dose. A loading dose:
A. Rapidly achieves drug levels in the therapeutic range
7. The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effect is the:
C. Onset of action
8. Phenytoin requires a trough level be drawn. Peak and trough levels are done:
D. To determine if a drug is in the therapeutic range
9. A laboratory result indicates the peak level for a drug is above the minimum toxic
concentration. This means that the:
B. Concentration will produce an adverse response
, 10. Drugs that are receptor agonists may demonstrate what property?
C. Desensitization or down-regulation with continuous use
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
B. An exaggerated response if abruptly discontinued
12. Factors that affect gastric drug absorption include:
C. Lipid solubility of the drug
13. Drugs administered via intravenous (IV) route:
B. Begin distribution into the body immediately
14. When a medication is added to a regimen for a synergistic effect, the combined effect of
the drugs is:
B. Greater than the sum of the effects of each drug individually
15. Which of the following statements about bioavailability is true?
A. Bioavailability issues are especially important for drugs with narrow therapeutic ranges or
sustained release mechanisms.
16. Which of the following statements about the major distribution barriers (blood-brain or
fetal placental) is true?
B. The blood-brain barrier slows the entry of many drugs into and from brain cells.
17. Drugs are metabolized mainly by the liver via Phase I or Phase II reactions. The
purpose of both of these types of reactions is to:
C. Change drug molecules to a form that an excretory organ can excrete
18. Once they have been metabolized by the liver, the metabolites may be:
A. More active than the parent drug
B. Less active than the parent drug
C. Totally “deactivated” so that they are excreted without any effect
,Chapter 2: Review of Basic Principles of Pharmacology
1. A patient’s nutritional intake and lab work reflects hypoalbuminemia. This is critical to
prescribing because:
A. Distribution of drugs to target tissue may be affected
2. Drugs that have a significant first-pass effect:
C. Are rapidly metabolized by the liver and may have little if any desired action
3. The route of excretion of a volatile drug will likely be:
B. The lungs
4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir of
the drug. Storage reservoirs:
C. Increase the length of time a drug is available and active
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
B. Biological half-life
6. Azithromycin dosing requires the first day’s dose be twice those of the other 4 days of
the prescription. This is considered a loading dose. A loading dose:
A. Rapidly achieves drug levels in the therapeutic range
7. The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effect is the:
C. Onset of action
8. Phenytoin requires a trough level be drawn. Peak and trough levels are done:
D. To determine if a drug is in the therapeutic range
9. A laboratory result indicates the peak level for a drug is above the minimum toxic
concentration. This means that the:
B. Concentration will produce an adverse response
, 10. Drugs that are receptor agonists may demonstrate what property?
C. Desensitization or down-regulation with continuous use
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
B. An exaggerated response if abruptly discontinued
12. Factors that affect gastric drug absorption include:
C. Lipid solubility of the drug
13. Drugs administered via intravenous (IV) route:
B. Begin distribution into the body immediately
14. When a medication is added to a regimen for a synergistic effect, the combined effect of
the drugs is:
B. Greater than the sum of the effects of each drug individually
15. Which of the following statements about bioavailability is true?
A. Bioavailability issues are especially important for drugs with narrow therapeutic ranges or
sustained release mechanisms.
16. Which of the following statements about the major distribution barriers (blood-brain or
fetal placental) is true?
B. The blood-brain barrier slows the entry of many drugs into and from brain cells.
17. Drugs are metabolized mainly by the liver via Phase I or Phase II reactions. The
purpose of both of these types of reactions is to:
C. Change drug molecules to a form that an excretory organ can excrete
18. Once they have been metabolized by the liver, the metabolites may be:
A. More active than the parent drug
B. Less active than the parent drug
C. Totally “deactivated” so that they are excreted without any effect
