ESTUDYR
NUR 545 EXAM 3 STUDY GUIDE (COMPLETE) UPDATED WITH
MOST TESTED QUESTIONS AND ANSWERS | GRADED A+ |
ASSURED SUCCESS WITH DETAILED RATIONALES
1. Naproxen is considered the first-line pharmacologic treatment for acute gout because it:
A. Prevents uric acid formation
B. Is safer for long-term therapy
C. Provides predictable anti-inflammatory effects with good tolerability
D. Eliminates urate crystals
Correct Answer: C
Rationale: NSAIDs like naproxen rapidly reduce inflammation and pain in gout with predictable
effects and lower short-term risk when used appropriately.
2. Colchicine has significant drug–drug interactions primarily because it is metabolized by:
A. CYP2D6
B. CYP1A2
C. CYP3A4 and P-glycoprotein pathways
D. Renal tubular secretion
Correct Answer: C
Rationale: CYP3A4 and P-glycoprotein inhibitors (e.g., cyclosporine, ketoconazole) increase
colchicine toxicity risk.
3. A patient taking colchicine and statins is at increased risk for which serious adverse
effect?
A. Hepatotoxicity
B. QT prolongation
C. Rhabdomyolysis
D. Agranulocytosis
Correct Answer: C
Rationale: Colchicine combined with statins increases muscle breakdown risk.
,ESTUDYR
4. Which adverse effect is associated with allopurinol therapy?
A. Hyperkalemia
B. Bone marrow suppression
C. Pulmonary fibrosis
D. Hypotension
Correct Answer: B
Rationale: Allopurinol may suppress bone marrow, leading to cytopenias.
5. Allopurinol hypersensitivity syndrome is characterized by which constellation of
findings?
A. Bradycardia, hypotension, rash
B. Rash, fever, eosinophilia, liver and kidney dysfunction
C. Tremors, ataxia, confusion
D. Bronchospasm and urticaria
Correct Answer: B
Rationale: This life-threatening reaction requires immediate drug discontinuation.
6. IV calcium chloride should be avoided or used cautiously in patients taking:
A. Beta blockers
B. ACE inhibitors
C. Digoxin
D. Warfarin
Correct Answer: C
Rationale: Calcium potentiates digoxin toxicity, causing severe bradycardia and dysrhythmias.
7. Patients receiving methotrexate for rheumatoid arthritis require routine monitoring of:
A. BMP only
B. CBC and CMP
C. Lipid panel
D. Thyroid function tests
Correct Answer: B
Rationale: Methotrexate can cause bone marrow suppression and hepatotoxicity.
, ESTUDYR
8. Hydroxychloroquine-induced visual loss is best prevented by:
A. Monthly eye exams
B. Baseline eye exam followed by annual exams
C. Limiting treatment duration to 6 months
D. Concurrent vitamin A supplementation
Correct Answer: B
Rationale: Retinal toxicity is dose-related and preventable with routine ophthalmologic
screening.
9. Raloxifene therapy should be discontinued before prolonged immobilization to prevent:
A. Stroke
B. Osteonecrosis
C. Deep vein thrombosis (DVT)
D. Pulmonary fibrosis
Correct Answer: C
Rationale: Raloxifene increases thromboembolic risk, especially during immobility.
10. Proper administration of alendronate includes which instruction?
A. Take at bedtime
B. Take with milk
C. Remain upright for at least 30 minutes after ingestion
D. Crush tablet if dysphagia is present
Correct Answer: C
Rationale: Upright positioning prevents esophageal irritation and injury.
11. Which symptom suggests alendronate-induced esophagitis?
A. Diarrhea
B. Pain with swallowing
C. Hematuria
D. Polyuria
NUR 545 EXAM 3 STUDY GUIDE (COMPLETE) UPDATED WITH
MOST TESTED QUESTIONS AND ANSWERS | GRADED A+ |
ASSURED SUCCESS WITH DETAILED RATIONALES
1. Naproxen is considered the first-line pharmacologic treatment for acute gout because it:
A. Prevents uric acid formation
B. Is safer for long-term therapy
C. Provides predictable anti-inflammatory effects with good tolerability
D. Eliminates urate crystals
Correct Answer: C
Rationale: NSAIDs like naproxen rapidly reduce inflammation and pain in gout with predictable
effects and lower short-term risk when used appropriately.
2. Colchicine has significant drug–drug interactions primarily because it is metabolized by:
A. CYP2D6
B. CYP1A2
C. CYP3A4 and P-glycoprotein pathways
D. Renal tubular secretion
Correct Answer: C
Rationale: CYP3A4 and P-glycoprotein inhibitors (e.g., cyclosporine, ketoconazole) increase
colchicine toxicity risk.
3. A patient taking colchicine and statins is at increased risk for which serious adverse
effect?
A. Hepatotoxicity
B. QT prolongation
C. Rhabdomyolysis
D. Agranulocytosis
Correct Answer: C
Rationale: Colchicine combined with statins increases muscle breakdown risk.
,ESTUDYR
4. Which adverse effect is associated with allopurinol therapy?
A. Hyperkalemia
B. Bone marrow suppression
C. Pulmonary fibrosis
D. Hypotension
Correct Answer: B
Rationale: Allopurinol may suppress bone marrow, leading to cytopenias.
5. Allopurinol hypersensitivity syndrome is characterized by which constellation of
findings?
A. Bradycardia, hypotension, rash
B. Rash, fever, eosinophilia, liver and kidney dysfunction
C. Tremors, ataxia, confusion
D. Bronchospasm and urticaria
Correct Answer: B
Rationale: This life-threatening reaction requires immediate drug discontinuation.
6. IV calcium chloride should be avoided or used cautiously in patients taking:
A. Beta blockers
B. ACE inhibitors
C. Digoxin
D. Warfarin
Correct Answer: C
Rationale: Calcium potentiates digoxin toxicity, causing severe bradycardia and dysrhythmias.
7. Patients receiving methotrexate for rheumatoid arthritis require routine monitoring of:
A. BMP only
B. CBC and CMP
C. Lipid panel
D. Thyroid function tests
Correct Answer: B
Rationale: Methotrexate can cause bone marrow suppression and hepatotoxicity.
, ESTUDYR
8. Hydroxychloroquine-induced visual loss is best prevented by:
A. Monthly eye exams
B. Baseline eye exam followed by annual exams
C. Limiting treatment duration to 6 months
D. Concurrent vitamin A supplementation
Correct Answer: B
Rationale: Retinal toxicity is dose-related and preventable with routine ophthalmologic
screening.
9. Raloxifene therapy should be discontinued before prolonged immobilization to prevent:
A. Stroke
B. Osteonecrosis
C. Deep vein thrombosis (DVT)
D. Pulmonary fibrosis
Correct Answer: C
Rationale: Raloxifene increases thromboembolic risk, especially during immobility.
10. Proper administration of alendronate includes which instruction?
A. Take at bedtime
B. Take with milk
C. Remain upright for at least 30 minutes after ingestion
D. Crush tablet if dysphagia is present
Correct Answer: C
Rationale: Upright positioning prevents esophageal irritation and injury.
11. Which symptom suggests alendronate-induced esophagitis?
A. Diarrhea
B. Pain with swallowing
C. Hematuria
D. Polyuria
