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Dermatology PANCE Questions 2026: High-Yield PA Exam Practice

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Dermatology PANCE Questions 2026 is a high-yield question-and-answer study resource designed to help physician assistant students master dermatologic conditions tested on the PANCE. This practice-focused guide covers common and critical skin disorders, including dermatitis, acne, psoriasis, bacterial and fungal infections, viral exanthems, skin cancers, and inflammatory conditions. Emphasizing clinical presentation, diagnosis, and management, this resource supports exam readiness by reinforcing key concepts and improving clinical reasoning aligned with the PANCE blueprint.

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Dermatology PANCE
Questions
Exam
2026
Questions and Answers
(A+ Grade Guarantee)

, B

Target lesions, also termed iris lesions, are characteristic of
A patient presents with a rash, erythema multiforme. The rash may be recurrent but typically
characterized by red macules resolves over 3-6 weeks.
and edematous papules with a
clearing center. This best
describes which of the following?
A erythema marginatum
B erythema multiforme
C varicella
D impetigo



C
In a patient suspected of having The most common site of involvement of seborrheic dermatitis is
seborrheic dermatitis, the most the scalp. Other common sites include the eyebrows, eyelids,
common site of involvement nasolabial fold, and ears
would be the
A upper extremities.
B thighs
C scalp.
D feet.


C

The history and exam is consistent with a scabies infection.
A 26 year-old male complains of Scrapings from the burrows should be examined for the presence
intense itching, especially at night of mites, eggs, and feces.
and after hot showers, for the
past 4 days. On physical
examination he has a few red
papules and areas of excoriation
on his volar wrists, between his
fingers, and around his waist.
Proper diagnosis should include
which of the following tests?
A KOH prep
B Gram stain
C Skin scraping microscopy
D Tzanck prep




2026

, D

Most people with Lyme Disease will have a positive serologic test
A 35 year-old female who after the first few weeks of infection and this would support the
recently returned from a diagnosis.
backpacking trip complains of
fatigue, malaise, fever, chills, and
arthralgias. Physical examination
reveals a 6 cm annular lesion
with a red border and a clear
center on her mid-back. Which of
the following laboratory tests
would support your diagnosis?
A KOH prep of skin scrapings
B Blood cultures
C RAST testing
D Serologic antibody testing




C

Acral lentiginous melanoma may occur on the palm, sole, nail bed,
or mucus membrane. This lesion is suspicious for a melanoma due
A 56 year-old, right hand to its irregular borders, being variegated in color, and its size. A
dominant, carpenter presents to biopsy is required and will ensure the diagnosis.
your clinic complaining of a
prolonged bruise under his left
thumbnail. He states that he first
noticed it one year ago. Physical
examination reveals a nontender
left thumb with a 6 mm macular
lesion located under the distal
nail bed. It is mixed dark brown
and black in color, with irregular
borders. The most likely
diagnosis is
A lentigo.
B trauma.
C melanoma.
D nevus




2026

, A

Rubeola (measles) is characterized by cough, coryza, and
conjunctivitis, along with a fever as a prodrome. Koplik spots
A mother brings in her 2 year-old appear prior to the onset of the typical erythematous,
child stating that the child has maculopapular rash and are pathognomonic for rubeola.
had a 3-day history of a
nonproductive cough, thick
copious rhinorrhea, conjunctivitis,
and a fever to 103 degrees.
Physical examination reveals a
well-hydrated child, with
numerous 1-2 mm white papules
on both buccal mucosa, normal
heart and breath sounds. This
presentation is most consistent
with early
A rubeola.
B rubella.
C varicella.
D streptococcal pharyngitis




A

Avoidance of cutaneous irritants, such as wool and other rough
A person with atopic dermatitis clothing, is the cornerstone of therapy for atopic dermatitis.
should be advised to
A avoid cutaneous irritants.
B take hot water baths or
showers
C use a high potency
glucocorticoid on skin after
bathing.
D begin a prophylactic antibiotic.




2026

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