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D236 Pathophysiology | WGU | 2025/2026 | 300+ Verified Q&As – Neuro, Endocrine, Renal, GI, Cardiac, Labs

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This document is a complete exam review and study guide for the WGU D236 Pathophysiology course for the 2025/2026 academic year, featuring 300+ updated and verified questions and answers across all major body systems. Structured in a Q&A format, this A+ resource is ideal for exam prep, proctored assessments, NCLEX-style reviews, and mastering disease mechanisms, signs and symptoms, and lab interpretation. Key systems and high-yield topics include: Neuro: Alzheimer’s vs. Parkinson’s, MS, ALS, Bell’s Palsy, cerebral contusion, TIA vs CVA, Huntington’s, ICP signs Endocrine: Cushing’s, Addison’s, Graves', Hashimoto's, diabetes types 1 & 2, DKA, SIADH, diabetes insipidus, acromegaly, hypothyroidism Renal: AKI vs. CKD, ESRD, pyelonephritis, glomerulonephritis, renal calculi, GFR, CRRT Gastrointestinal: GERD, Crohn’s, ulcerative colitis, diverticulitis, pancreatitis, cirrhosis, hepatitis A–E, colon cancer signs Cardiovascular: MI, endocarditis, pericarditis, atherosclerosis, angina, valve disease, right vs. left HF, JVD, stroke risk Hematologic: Anemia types (iron-deficiency, B12, hemolytic, aplastic, sickle cell), leukemia, lymphoma, Reed-Sternberg cells Integumentary & Burns: Skin cancer types, lupus, dermatitis, eczema, pressure ulcers, Rule of 9s, superficial vs. full-thickness burns Respiratory: COPD, asthma, pneumonia, pneumothorax, cor pulmonale, TB, coal worker’s pneumoconiosis Electrolytes & Labs: ABG interpretation, anion gap, hyper/hyponatremia, potassium shifts in acidosis, BMP/CMP/CBC analysis Reproductive: PID, PCOS, endometriosis, STIs (chlamydia, gonorrhea), prostate/testicular cancer treatments, breast cancer (triple negative) Musculoskeletal: Osteoarthritis, osteoporosis, Paget’s disease, fractures, compartment syndrome, rhabdomyolysis Immune & Cancer: Lupus, myasthenia gravis, lymphoma types, autoimmune mechanisms, tumor markers (e.g., HE4, troponin, CK) This document is ideal for: WGU nursing students in D236 Pathophysiology Pre-NCLEX or ATI/HESI exam prep Students in RN/BSN programs seeking clinical mastery Tutors or educators needing comprehensive system-based content Questions are aligned with clinical case-style reasoning, and many include pathophysiological mechanisms and lab correlations, reinforcing deep understanding and exam readiness. Keywords: D236, WGU, pathophysiology, NCLEX prep, ABG interpretation, electrolyte imbalance, heart failure, kidney disease, COPD, diabetes, Cushing’s, Addison’s, autoimmune disease, lupus, anemia, stroke, endocrine, GI disorders, lab values, burns, infectious disease, neuro disorders, cancer, renal failure, inflammation

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WGU Pathophysiology D236 2025/2026
Exam Questions and Correct Answers |
New Update



Describe how your body responds to an infection. - 🧠 ANSWER ✔✔T cells

produce cytokines, which stimulate B cells. B cells produce antibodies.

Identify role of DNA changes in congenital abnormalities. - 🧠 ANSWER

✔✔Mutations in genes or chromosomal abnormalities


How does development disrupts congenital abnormalities? - 🧠 ANSWER

✔✔Alterations of DNA

,Describes factors that disrupt homeostasis and how disruptions affect

wellbeing. - 🧠 ANSWER ✔✔(ex) Fluid and electrolyte shifts can cause n/v

or dysrhythmias.


Explain RAAS - 🧠 ANSWER ✔✔Renin-angiotensin-aldosterone system


1. Reduce blood flow causes kidneys to release renin

> produce angiotensin I > converts angiotensin I to angiotensin II >

vasoconstriction > release aldosterone > kidneys conserve sodium and

water > Result less water lost in urine and blood pressure maintained.


DKA - 🧠 ANSWER ✔✔increased anion gap, decreased HCO3


How do kidneys compensate for alkalosis - 🧠 ANSWER ✔✔retain H and

excrete HCO3

Untreated acidosis leads to an increase in which electrolyte? - 🧠 ANSWER

✔✔Potassium


West Nile Virus - 🧠 ANSWER ✔✔Transmitted through the bite of an

infected mosquito. Severe signs and symptoms; high fever, headache and

stiff neck

, Lyme disease - 🧠 ANSWER ✔✔Tick-borne disease caused by the

spirochete Borrelia burgdorferi.


Erythema infectiosum - 🧠 ANSWER ✔✔a febrile upper respiratory illness in

a child followed by the sudden appearance of red, flushed cheeks, "fifth

disease"

Obesity ad diabetes are risk factors for having a child with _____. - 🧠

ANSWER ✔✔Spina bifida


Trousseau's sign - 🧠 ANSWER ✔✔arm/carpal spasm associated with

hypocalcemia


Cause and sign of spina bifida - 🧠 ANSWER ✔✔results from failure of

neural tube to close. sign - fluid filled sac on lower back.


hemophilia is more common in - 🧠 ANSWER ✔✔males


Prenatal exposure to alcohol includes - 🧠 ANSWER ✔✔ND-PAE,

decreased brain function, FAS


Connective vs muscle tissue disorders - 🧠 ANSWER ✔✔Connective- RA,

Scleroderma, Lupus

Muscle - MS, Muscular dystrophy, Myasthenia Gravia

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