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RQI 2025 ACLS
Healthcare Provider – MOST DIFFICULT & MOST TESTED QUESTIONS (1–10)
Question 1
A 62-year-old man collapses in the hospital lobby. He is unresponsive and pulseless. The
monitor shows ventricular fibrillation (VF). What is the immediate next step?
A. Begin high-quality CPR and prepare for defibrillation
B. Administer IV epinephrine immediately before CPR
C. Intubate the patient before any chest compressions
D. Check blood glucose
Correct Answer: A
Explanation:
For shockable rhythms like VF, early defibrillation and high-quality CPR are crucial for survival.
Epinephrine is given after the first shock, and intubation can be performed during CPR if skilled
personnel are available.
Question 2
During an ACLS scenario, a patient in asystole is identified. What is the first-line treatment?
A. CPR and IV/IO access
B. Immediate defibrillation
C. Amiodarone bolus
D. Administer adenosine
,Correct Answer: A
Explanation:
Asystole is non-shockable. High-quality CPR and establishing IV/IO access are the priority.
Medications like epinephrine are given every 3–5 minutes during CPR.
Question 3
A patient with pulseless VT is being treated. After one shock and 2 minutes of CPR, the rhythm
persists. What should you do next?
A. Administer 1 mg IV/IO epinephrine
B. Deliver a second shock and continue CPR
C. Give 6 mg adenosine
D. Call for immediate intubation
Correct Answer: B
Explanation:
For persistent shockable rhythms, the protocol is: defibrillate, CPR, consider epinephrine after
the second shock, and repeat the cycle. Adenosine is for supraventricular tachycardia, not VT.
Question 4
During a rapid response, a patient shows severe bradycardia with hypotension, altered mental
status, and chest discomfort. What is the first ACLS intervention?
A. Atropine 0.5 mg IV
B. Immediate CPR
C. Defibrillation
D. Administer amiodarone
Correct Answer: A
Explanation:
For symptomatic bradycardia, atropine is first-line. If atropine fails, consider transcutaneous
pacing, dopamine, or epinephrine infusion. CPR is not indicated unless the patient becomes
pulseless.
Question 5
, A patient is post-cardiac arrest and remains unconscious with return of spontaneous
circulation (ROSC). What is the priority intervention?
A. Optimize ventilation and oxygenation, maintain blood pressure, and perform targeted
temperature management
B. Immediate extubation
C. Start high-dose epinephrine
D. Rapid transport to cath lab regardless of stability
Correct Answer: A
Explanation:
Post-cardiac arrest care focuses on hemodynamic stability, oxygenation, and neurological
protection. Targeted temperature management improves neurological outcomes. Immediate
extubation or unnecessary high-dose drugs are unsafe.
Question 6
Which rhythm is considered shockable in ACLS?
A. Ventricular fibrillation (VF)
B. Asystole
C. Pulseless electrical activity (PEA)
D. Sinus bradycardia
Correct Answer: A
Explanation:
VF and pulseless VT are shockable. Asystole and PEA are non-shockable, and require CPR and
medication, not defibrillation.
Question 7
During ACLS, you are administering epinephrine every 3–5 minutes. Which of the following is a
key reason?
A. To maintain coronary and cerebral perfusion during CPR
B. To treat hypoglycemia
C. To reduce chest pain
D. To immediately convert VF
Correct Answer: A