© MPI – Maria Paola Ippolito. All rights reserved
, What we will explore
© MPI – Maria Paola Ippolito. All rights reserved
The protagonists of the Krebs Cycle: who
they are and how to remember them
easily.
Energy in motion: how we transform food
and oxygen into vital “fuel”
Insights from the future: a glimpse into
how biology meets physics to explain the
secrets of life.
Pro-Tips for the exam: quick diagrams and
techniques to never forget anything again.
, CARBOHYDRATES PROTEINS LIPIDS
© MPI – Maria Paola Ippolito. All rights reserved
The catabolism of carbohydrates,
Acetyl-CoA lipids, and amino acids converges into
terminal metabolism, which consists of
the Krebs cycle (also known as the
tricarboxylic acid cycle or citric acid
cycle) and oxidative phosphorylation,
both of which take place in the
mitochondria.
The catabolism of carbohydrates and
KREBS CYCLE lipids, as well as that of many amino
acids, produces the same molecule:
acetyl-CoA, the pivotal molecule of
metabolism.
, Acetyl-CoA
© MPI – Maria Paola Ippolito. All rights reserved
Acetyl-CoA entering the Krebs cycle consists of an acetyl group linked to CoA through a
thioester bond (Sulfur-Carbon). This bond is extremely energetic and "unstable": when it
breaks during the first reaction of the Krebs cycle, it releases the energy necessary to
jumpstart the entire process.
Acetyl-CoA is often called the "crossroads of metabolism." Without this molecule, the energy
contained in the food we eat could never enter the Krebs cycle to be transformed into ATP.
Source: NEUROtiker via Wikimedia Commons
, What we will explore
© MPI – Maria Paola Ippolito. All rights reserved
The protagonists of the Krebs Cycle: who
they are and how to remember them
easily.
Energy in motion: how we transform food
and oxygen into vital “fuel”
Insights from the future: a glimpse into
how biology meets physics to explain the
secrets of life.
Pro-Tips for the exam: quick diagrams and
techniques to never forget anything again.
, CARBOHYDRATES PROTEINS LIPIDS
© MPI – Maria Paola Ippolito. All rights reserved
The catabolism of carbohydrates,
Acetyl-CoA lipids, and amino acids converges into
terminal metabolism, which consists of
the Krebs cycle (also known as the
tricarboxylic acid cycle or citric acid
cycle) and oxidative phosphorylation,
both of which take place in the
mitochondria.
The catabolism of carbohydrates and
KREBS CYCLE lipids, as well as that of many amino
acids, produces the same molecule:
acetyl-CoA, the pivotal molecule of
metabolism.
, Acetyl-CoA
© MPI – Maria Paola Ippolito. All rights reserved
Acetyl-CoA entering the Krebs cycle consists of an acetyl group linked to CoA through a
thioester bond (Sulfur-Carbon). This bond is extremely energetic and "unstable": when it
breaks during the first reaction of the Krebs cycle, it releases the energy necessary to
jumpstart the entire process.
Acetyl-CoA is often called the "crossroads of metabolism." Without this molecule, the energy
contained in the food we eat could never enter the Krebs cycle to be transformed into ATP.
Source: NEUROtiker via Wikimedia Commons
