EXAM 1 QUESTIONS WITH CORRECT
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A+||UPDATED 2026/2027
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NSAIDs use in inflammation - ANSWER ✓ -inhibit PGs
-Anti-inflammatory dose often higher than analgesic dose
-should be used continuously until inflammation is resolved (don't stop/start
dosing)
Glucocorticoids - ANSWER ✓ -steroids: powerful anti-inflammatory and
immunosuppressive effects
-many uses/indications
-resolve inflammation..disease process may continue
Common Glucocorticoids - ANSWER ✓ -betamethasone
-cortisone
-dexamethasone
-hydrocortisone
-paramethasone
-prednisolone
-prednisone
-many others
Anti-inflammatory effects (glucocorticoids) - ANSWER ✓ -act in inflammatory
cells (macrophages, leukocytes)
-drug binds to glucocortcoid receptor in cytoplasm
-drug-receptor travels to nucleus and decrease of inflammatory proteins and
increase antiinflammatory proteins
Anti-inflammatory administration methods - ANSWER ✓ Oral, systemic:
, 5, 4, 3, 2, 1
Injection:
Intra-articular (3-4 yrs)
Other:
Inhalation, topical, nasal, ophthalmic, otic (good for specific=less side effects)
Glucocorticoids adverse effects: primary - ANSWER ✓ Catabolic effect on bone,
muscle, ligaments, tendon, skin
Glucocorticoids adverse effects: others - ANSWER ✓ -salt/water retention
-increased infection
-gastric ulcers
-Glucose intolerance
-Glaucoma
-Adrenal suppresion (supress cortisol production)
Glucocorticoids adrenocortical shock - ANSWER ✓ -Extensive vascular collapse
(severe hypotension, organ damage)
-Can occur when GCs are suddenly discontinued (go off under supervision)
Muscle relaxants primary goal and use - ANSWER ✓ -Selective decrease skeletal
muscle excitability
-muscle spasms spasticity
Agents used to treat muscle spasm - ANSWER ✓ Centrally-acting anti-spasm
drugs (diazepam "valium")
-tend to work in central nervous system
Muscle spasms - ANSWER ✓ Injury usually to:
-muscle
-peripheral nerve
-tonic contraction in paraspinals
-Traps, etc.
Spasicity - ANSWER ✓ CNS lesion (SCI, CP, CVA, etc.)
Exaggerated stretch reflex
Centrally-acting Antispasm drugs - ANSWER ✓ Used commonly in: