MICR 270 Final Exam Questions With
Complete Answers
Inflammatory Pathway - ANSWER 1. Breach
2. Vasodilation
3. Permeabilization
4. Chemotaxis
5. Margination
6. Extravasation
7. Phagocytosis
Phagocytosis Pathway - ANSWER 1. Attachment
2. Ingestion
3. Fusion
4. Digestion
5. Release
adaptive immune response - ANSWER 1. Antigen Recognition
2. Lymphocyte activation
3. Elimination
4. Apoptosis
,5. Memory
antigen processing - ANSWER 1. Antigen engulfment
2. Proteolytic processing
3. MHC Antigen Complex
4. Cell surface expression
5. Recognition by T-helper cells
T cell dependent B cell activation - ANSWER 1. Peptide MHC II complex
2. TCR-peptide MHC complex
3. Expression of co-stimulatory molecules
4. Co-stimulation
5. Cytokine secretion
6. Humoral response
HIV Response - ANSWER 1. Primary infection
-generate an immune response to the virus within a few weeks
2. Acute HIV syndrome
-HIV targets CD4 cells and their prevalence drastically decreases, while the viral load
drastically increases and transmission risk is HIGH
, 3. Chronic infection/clinical latency
HIV multiples at a steady rate, and anti-HIV antibodies are detectable, HIV continues to
evade the IR through mutations.
4. AIDS symptoms
-CD4 count < 200 cells, viral load is high and IS severely compromised
TLR signalling - ANSWER TLRS recognize through ramps or damps, then the engulfed
pathogen is presented to the MHC and the production of co-stimulatory molecules is
increased, and an immunocompetent naive T cell binds to the MHC and can initiate an
adaptive IR.
Humoral Activation - ANSWER Activated and differentiated TH2 cells activate B cells and
induce their differentiation into plasmocytes. Plasmocytes then secrete a large number of
antibodies for the invading antigen.
Cell-mediated activation - ANSWER Activated and differentiated TH1 cells active CD8+
and induce their differentiation into CTLs. CTLs then recognize and eliminate pathogens
through their MHC I complex.
Cancer immunoediting - ANSWER elimination:
tutor cell arises in a tissue, the immune system acts to remove it through NK cells and T
cells.
Complete Answers
Inflammatory Pathway - ANSWER 1. Breach
2. Vasodilation
3. Permeabilization
4. Chemotaxis
5. Margination
6. Extravasation
7. Phagocytosis
Phagocytosis Pathway - ANSWER 1. Attachment
2. Ingestion
3. Fusion
4. Digestion
5. Release
adaptive immune response - ANSWER 1. Antigen Recognition
2. Lymphocyte activation
3. Elimination
4. Apoptosis
,5. Memory
antigen processing - ANSWER 1. Antigen engulfment
2. Proteolytic processing
3. MHC Antigen Complex
4. Cell surface expression
5. Recognition by T-helper cells
T cell dependent B cell activation - ANSWER 1. Peptide MHC II complex
2. TCR-peptide MHC complex
3. Expression of co-stimulatory molecules
4. Co-stimulation
5. Cytokine secretion
6. Humoral response
HIV Response - ANSWER 1. Primary infection
-generate an immune response to the virus within a few weeks
2. Acute HIV syndrome
-HIV targets CD4 cells and their prevalence drastically decreases, while the viral load
drastically increases and transmission risk is HIGH
, 3. Chronic infection/clinical latency
HIV multiples at a steady rate, and anti-HIV antibodies are detectable, HIV continues to
evade the IR through mutations.
4. AIDS symptoms
-CD4 count < 200 cells, viral load is high and IS severely compromised
TLR signalling - ANSWER TLRS recognize through ramps or damps, then the engulfed
pathogen is presented to the MHC and the production of co-stimulatory molecules is
increased, and an immunocompetent naive T cell binds to the MHC and can initiate an
adaptive IR.
Humoral Activation - ANSWER Activated and differentiated TH2 cells activate B cells and
induce their differentiation into plasmocytes. Plasmocytes then secrete a large number of
antibodies for the invading antigen.
Cell-mediated activation - ANSWER Activated and differentiated TH1 cells active CD8+
and induce their differentiation into CTLs. CTLs then recognize and eliminate pathogens
through their MHC I complex.
Cancer immunoediting - ANSWER elimination:
tutor cell arises in a tissue, the immune system acts to remove it through NK cells and T
cells.
