ALAT Practice Questions
In 1967, the Animal Care Panel changed its name to what? - answer American
Association for Laboratory Animal Science
Who led the group of veterinarians that met in Chicago and formed the Animal Care
Panel in 1950? – answer Dr. Nathan Brewer
What is NOT a method used by researchers to reduce the number of animals used?
Using invertebrates rather than mammals
Cell culture
Computer models
Improved statistical methods - answer Using invertebrates rather than mammals
Why are animals used to study human disease?
There are no regulations that restrict the use of animals in research.
The physiological processes in animal models can be very similar to humans.
It takes less time to perform an experiment with animals than with humans.
It is less expensive to use animals for research studies. - answerThe physiological
processes in animal models can be very similar to humans.
Which member of the research team coordinates animal care activities and advises on
the selection of appropriate animal models?
Laboratory animal technician
Principal investigator
Laboratory animal veterinarian
Research technician - answerLaboratory animal veterinarian
What does the acronym "SOP" stand for?
Systems operating procedure
Standard operations plan
Standard organizational process
Standard operating procedure - answerStandard operating procedure
Which member of the research team plans and coordinates all phases of the research
work?
Facility director
Principal investigator
Institutional Official
Laboratory animal veterinarian - answerPrincipal investigator
,Specific legal protections for employees who discover and report issues on
noncompliance are also known as what?
Immunity laws
Snitch statute
Whistleblower laws
Exposure protections - answerWhistleblower laws
What is the first step to take to try to resolve a conflict with a co-worker?
Talk to your co-worker and see if you can discuss the issues and work out the problem.
Report the problem to your supervisor immediately.
Try to do your work without making your co-worker upset.
Talk to the human resources department and ask for a transfer. - answerTalk to your
co-worker and see if you can discuss the issues and work out the problem.
What describes the correct sequential order of the parts of the research process?
Hypothesis, experimental plan, IACUC protocol, conduct of study, analysis of data,
reporting of results
Experimental plan, hypothesis, IACUC protocol, conduct of study, analysis of data,
reporting of results
Hypothesis, conduct of study, IACUC protocol, experimental plan, analysis of data,
reporting of results
Hypothesis, IACUC protocol, analysis of data, conduct of study, experimental plan,
reporting of results - answerHypothesis, experimental plan, IACUC protocol, conduct of
study, analysis of data, reporting of results
Which disease does not have a spontaneous animal model?
Narcolepsy
Tuberculosis
Type II diabetes
Atherosclerosis - answerTuberculosis
Giving an animal an injection of synthetic hormone, compared with a natural hormone,
is an example of what kind of scientific research?
Safety evaluation
Basic research
Applied research
New drug study - answerNew drug study
What does the animal use protocol NOT include?
All drugs or experimental agents administered
A complete description of how the animals will be used
The health status of all employees listed on the protocol
The species and numbers of animals to be used - answerThe health status of all
employees listed on the protocol
What would NOT be required if the proposed endpoint of the study is death?
,Alternatives endpoints must be considered.
Analgesia may not be given to avoid affecting experimental results
The endpoint must be justified to the IACUC in writing.
The minimum number of animals required for statistical significance should be used. -
answerAnalgesia may not be given to avoid affecting experimental results
What is NOT a disease that may be induced in a laboratory animal by genetic
manipulation?
Inflammatory bowel disease
Malaria
Multiple sclerosis
Cystic fibrosis - answerMalaria
In most facilities, no research experiments on live vertebrate animals may begin before
the experiments are approved by which body?
The PHS
The IACUC
The FDA
The USDA - answerThe USDA
What is an example of applied research?
Using cows for developing a new vaccine for chicken pox
Testing the safety of a new antibiotic ointment
Observing orangutans in their natural habitat
Studying the normal brain function of rats - answerUsing cows for developing a new
vaccine for chicken pox
Field studies do not take place at an institution, so are not subject to regulation by the
Animal Welfare Act.
True
False - answerFalse
According to the experimental plan, the experimental group will receive 2 injections of
test substance A dissolved in saline, one week apart. What will the control group
receive?
2 injections of test substance A, two weeks apart
2 injections of saline, one week apart
2 injections of test substance B, one week apart
1 injection of test substance C - answer2 injections of saline, one week apart
What is the term for a fertilized ovum?
Ovocyte
Zygote
Gamete
Fetus - answerZygote
, What type of cells do NOT have paired chromosomes?
Hepatocytes
Neurons
Spermatozoa
Lymphocytes - answerSpermatozoa
What are genes made from?
RNA
Carbohydrates
Amino acids
DNA - answerDNA
What do genes consist of?
RNA in the ribosome
RNA in the chromosome
DNA in the chromosome
DNA in the ribosome - answerDNA in the chromosome
What is a change or damage in a gene called?
A mutation
A zygote
A variation
A trait - answerA mutation
When changing cages you notice that the offspring of one set of mice have an unusual
behavior. What should you do?
Tell the researchers, because it might be a genetic mutation that would affect the study.
Euthanize all the mice.
Euthanize the offspring and separate the breeding pair.
Just go about your normal duties, ignoring this behavior. - answerTell the researchers,
because it might be a genetic mutation that would affect the study.
A mouse that contains new DNA designed to change a specific gene is called a "knock-
out"
False
True - answerFalse
What type of mouse contains altered DNA designed to turn OFF a specific gene?
A knockout mouse
A genotyped mouse
A punchout mouse
A knockin mouse - answerA knockout mouse
What is the time between fertilization and birth called?
Parturition
Estrus
In 1967, the Animal Care Panel changed its name to what? - answer American
Association for Laboratory Animal Science
Who led the group of veterinarians that met in Chicago and formed the Animal Care
Panel in 1950? – answer Dr. Nathan Brewer
What is NOT a method used by researchers to reduce the number of animals used?
Using invertebrates rather than mammals
Cell culture
Computer models
Improved statistical methods - answer Using invertebrates rather than mammals
Why are animals used to study human disease?
There are no regulations that restrict the use of animals in research.
The physiological processes in animal models can be very similar to humans.
It takes less time to perform an experiment with animals than with humans.
It is less expensive to use animals for research studies. - answerThe physiological
processes in animal models can be very similar to humans.
Which member of the research team coordinates animal care activities and advises on
the selection of appropriate animal models?
Laboratory animal technician
Principal investigator
Laboratory animal veterinarian
Research technician - answerLaboratory animal veterinarian
What does the acronym "SOP" stand for?
Systems operating procedure
Standard operations plan
Standard organizational process
Standard operating procedure - answerStandard operating procedure
Which member of the research team plans and coordinates all phases of the research
work?
Facility director
Principal investigator
Institutional Official
Laboratory animal veterinarian - answerPrincipal investigator
,Specific legal protections for employees who discover and report issues on
noncompliance are also known as what?
Immunity laws
Snitch statute
Whistleblower laws
Exposure protections - answerWhistleblower laws
What is the first step to take to try to resolve a conflict with a co-worker?
Talk to your co-worker and see if you can discuss the issues and work out the problem.
Report the problem to your supervisor immediately.
Try to do your work without making your co-worker upset.
Talk to the human resources department and ask for a transfer. - answerTalk to your
co-worker and see if you can discuss the issues and work out the problem.
What describes the correct sequential order of the parts of the research process?
Hypothesis, experimental plan, IACUC protocol, conduct of study, analysis of data,
reporting of results
Experimental plan, hypothesis, IACUC protocol, conduct of study, analysis of data,
reporting of results
Hypothesis, conduct of study, IACUC protocol, experimental plan, analysis of data,
reporting of results
Hypothesis, IACUC protocol, analysis of data, conduct of study, experimental plan,
reporting of results - answerHypothesis, experimental plan, IACUC protocol, conduct of
study, analysis of data, reporting of results
Which disease does not have a spontaneous animal model?
Narcolepsy
Tuberculosis
Type II diabetes
Atherosclerosis - answerTuberculosis
Giving an animal an injection of synthetic hormone, compared with a natural hormone,
is an example of what kind of scientific research?
Safety evaluation
Basic research
Applied research
New drug study - answerNew drug study
What does the animal use protocol NOT include?
All drugs or experimental agents administered
A complete description of how the animals will be used
The health status of all employees listed on the protocol
The species and numbers of animals to be used - answerThe health status of all
employees listed on the protocol
What would NOT be required if the proposed endpoint of the study is death?
,Alternatives endpoints must be considered.
Analgesia may not be given to avoid affecting experimental results
The endpoint must be justified to the IACUC in writing.
The minimum number of animals required for statistical significance should be used. -
answerAnalgesia may not be given to avoid affecting experimental results
What is NOT a disease that may be induced in a laboratory animal by genetic
manipulation?
Inflammatory bowel disease
Malaria
Multiple sclerosis
Cystic fibrosis - answerMalaria
In most facilities, no research experiments on live vertebrate animals may begin before
the experiments are approved by which body?
The PHS
The IACUC
The FDA
The USDA - answerThe USDA
What is an example of applied research?
Using cows for developing a new vaccine for chicken pox
Testing the safety of a new antibiotic ointment
Observing orangutans in their natural habitat
Studying the normal brain function of rats - answerUsing cows for developing a new
vaccine for chicken pox
Field studies do not take place at an institution, so are not subject to regulation by the
Animal Welfare Act.
True
False - answerFalse
According to the experimental plan, the experimental group will receive 2 injections of
test substance A dissolved in saline, one week apart. What will the control group
receive?
2 injections of test substance A, two weeks apart
2 injections of saline, one week apart
2 injections of test substance B, one week apart
1 injection of test substance C - answer2 injections of saline, one week apart
What is the term for a fertilized ovum?
Ovocyte
Zygote
Gamete
Fetus - answerZygote
, What type of cells do NOT have paired chromosomes?
Hepatocytes
Neurons
Spermatozoa
Lymphocytes - answerSpermatozoa
What are genes made from?
RNA
Carbohydrates
Amino acids
DNA - answerDNA
What do genes consist of?
RNA in the ribosome
RNA in the chromosome
DNA in the chromosome
DNA in the ribosome - answerDNA in the chromosome
What is a change or damage in a gene called?
A mutation
A zygote
A variation
A trait - answerA mutation
When changing cages you notice that the offspring of one set of mice have an unusual
behavior. What should you do?
Tell the researchers, because it might be a genetic mutation that would affect the study.
Euthanize all the mice.
Euthanize the offspring and separate the breeding pair.
Just go about your normal duties, ignoring this behavior. - answerTell the researchers,
because it might be a genetic mutation that would affect the study.
A mouse that contains new DNA designed to change a specific gene is called a "knock-
out"
False
True - answerFalse
What type of mouse contains altered DNA designed to turn OFF a specific gene?
A knockout mouse
A genotyped mouse
A punchout mouse
A knockin mouse - answerA knockout mouse
What is the time between fertilization and birth called?
Parturition
Estrus
