BMTCN Study Guide: Hematopoiesis, Immunity &
Transplant Biology|Latest Update complete with
Verified A+ Graded Answers
Myeloid
erythrocyte, platelets, neutrophil, basophil, eosinophil, monoblast, macrophage, monocyte
lymphoid
pre- B cell, pre-t cell, plasma cell, natural killer cell, t lymphocyte
innate immunity
occurs naturally- phagocytes release inflammatory mediators
acquired immunity
response of either b or t cells to antigens
senescence
loss of cells power to divide and grow
immunosenescence
reduction in size of thymus and function of immune cells
first responders
myeloid
second responders
lymphoid- pathogen specific
syngeneic
identical twin, don't need immunosuppression, con- no graft vs tumor effect
graft vs. tumor effect
-promoted by withdrawal of immunosuppressant therapy
-promoted by DLIs
-dec. in absence of acute gvhd
-higher rate of relapse
, DLI
infusion of lymphocytes from donor given when there is relapsed disease. Attempt to create
GVT effect
PBSCT
- 70 %, - faster engraftment, no anesthesia risks, dec. likelihood of contamination by tumor, -
higher risk of gvhd, - but better gvt effect- so dosent make sense for SCD
G-CSF
filgrastim. a glycoprotein stimulates the production of stem cells by binding to certain cell
surface areas
GM-CSF
sargramostim. lower stem cell yields. and inc adverse events. similar mechanism of action
chemo induced mobilization
chemo causes reduction in production of blood cells thus stimulating hematapoetic recovery.
-cyclophosphamide
-paclitaxel
-etoposide
-cytarabine
-improved mobilization
-more rapid engraftment
-reduced risk of tumor cell contamination
chemokine antagonist mobilization
directly induce mobilization by working as antagonist between the chemokine stromal-derived-
factor- 1 and receptor CXCR4.
-Plerixafor
-often in combination with GCSF
red bone marrow
produces stem cells that create rbcs, whit bcs, and plts. found in long and flat bones
yellow bone marrow
produce stromal stem cells that produce fat, cartilage and bone. found in long bones
where are hematopoitic stem cells produced?
Transplant Biology|Latest Update complete with
Verified A+ Graded Answers
Myeloid
erythrocyte, platelets, neutrophil, basophil, eosinophil, monoblast, macrophage, monocyte
lymphoid
pre- B cell, pre-t cell, plasma cell, natural killer cell, t lymphocyte
innate immunity
occurs naturally- phagocytes release inflammatory mediators
acquired immunity
response of either b or t cells to antigens
senescence
loss of cells power to divide and grow
immunosenescence
reduction in size of thymus and function of immune cells
first responders
myeloid
second responders
lymphoid- pathogen specific
syngeneic
identical twin, don't need immunosuppression, con- no graft vs tumor effect
graft vs. tumor effect
-promoted by withdrawal of immunosuppressant therapy
-promoted by DLIs
-dec. in absence of acute gvhd
-higher rate of relapse
, DLI
infusion of lymphocytes from donor given when there is relapsed disease. Attempt to create
GVT effect
PBSCT
- 70 %, - faster engraftment, no anesthesia risks, dec. likelihood of contamination by tumor, -
higher risk of gvhd, - but better gvt effect- so dosent make sense for SCD
G-CSF
filgrastim. a glycoprotein stimulates the production of stem cells by binding to certain cell
surface areas
GM-CSF
sargramostim. lower stem cell yields. and inc adverse events. similar mechanism of action
chemo induced mobilization
chemo causes reduction in production of blood cells thus stimulating hematapoetic recovery.
-cyclophosphamide
-paclitaxel
-etoposide
-cytarabine
-improved mobilization
-more rapid engraftment
-reduced risk of tumor cell contamination
chemokine antagonist mobilization
directly induce mobilization by working as antagonist between the chemokine stromal-derived-
factor- 1 and receptor CXCR4.
-Plerixafor
-often in combination with GCSF
red bone marrow
produces stem cells that create rbcs, whit bcs, and plts. found in long and flat bones
yellow bone marrow
produce stromal stem cells that produce fat, cartilage and bone. found in long bones
where are hematopoitic stem cells produced?
