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HESI Pharmacology Practice Test 2026/2027 | Nursing Study Guide

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Prepare for the HESI Pharmacology Exam with this 2026/2027 practice test. Includes verified questions, detailed explanations, and study strategies to help nursing students master medications, dosages, and patient care concepts for HESI and NCLEX-PN exam success.

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Institution
HESI Pharmacology
Course
HESI Pharmacology

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Page 1 of 24 / Ideal for students seeking high-yield, exam-ready
HESI
HESI Pharmacology
Pharmacology
preparation
Practice
Practice
and confidence
Test
Test / questions
for & answers for quick study and test prep.




HESI Pharmacology Practice Test

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Terms in this set (71)


The nurse reviews the new prescription, phenelzine
(Nardil), a monoamine oxidase inhibitor (MAOI), for
a client with depression on the psychiatric unit.
Which information is most important for the nurse to
assess?

A
A. Consumption of any alcohol or tyramine rich
foods
B. Reports of nausea or vomiting
C. Therapeutic serum drug levels
D. Blood pressure and pulse prior to taking each
dose

The nurse is administering haloperidol 0.5 mg IM
PRN to a client for the first time. What side effects
should the nurse assess thr client during the initial
dose?
B
A. Bradykinesia
B. Dystonia
C. Somatization
D. Akathisia




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,Page 2 of 24 / Ideal for students seeking high-yield, exam-ready
HESI
HESI Pharmacology
Pharmacology
preparation
Practice
Practice
and confidence
Test
Test / questions
for & answers for quick study and test prep.


While reviewing the client's electronic medical
record (EMR), the nurse assesses a client who is at
risk for a possible interaction with an over-the-
counter (OTC) decongestant. Which client health
history should the nurse report to the health care
provider concerning the OTC medication? (Select
B,C all that apply)


A. Type 1 diabetes mellitus (DM)
B. Closed angle glaucome
C. Chronic hypertension
D. Rheumatoid arthritis
E. Crohn's disease

A client prescribed ipratropium reports nausea,
blurred vision, headaches, and insomnia after using
the inhaler. Which action should the nurse
implement first?


A. Withhold the medication and report symptoms
A and vital signs to the healthcare provider
B. Give PRN medication for nausea and vomiting
and evaluate client in 30 minutes
C. reassure client that the ipratropium given will
alleviate the symptoms
D. Delay administration of ipratropium until the next
maintenance medication is scheduled

A client diagnosed with multiple sclerosis is
experiencing profound weakness, blurry vision, and
shooting pains in both legs. Which medication is
considered the best course of treatment for the
nurse to administer?
A

A. High dose methylprednisolone intravenously
B. Baclofen three times a day
C. Broad spectrum antibiotic coverage orally
D. Immunomodulatory drug therapy periodically




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, Page 3 of 24 / Ideal for students seeking high-yield, exam-ready
HESI
HESI Pharmacology
Pharmacology
preparation
Practice
Practice
and confidence
Test
Test / questions
for & answers for quick study and test prep.


The nurse administers 30 mL of lactulose for a client
with stage 2 hepatic encephalopathy. Which
assessment finding would indicate the medication is
being therapeutic?
A
A. A decrease in blood ammonia levels
B. A softening in the stools
C. An increase in glucose absorption
D. A suppression of gut acidification

The nurse is teaching a client who is newly
diagnosed with type 1 diabetes about neutral
protamine Hagedor (NPH) insulin. Which statement
by the client indicates an understanding of how the
medication works?


A A. It facilitates the transport of glucose into the cells
B. It stimulates the function of beta cells in the
pancreas
C. It increases the intracellular receptor site
sensitivity
D. It delays the carbohydrate digestion and
absorption

The nurse should withhold which medication if a
client reports nausea, vomiting, and diarrhea?


A A. Colchicine (Mitigare, Colcrys)
B. Erythromycin (E-mycin)
C. Naproxen (Aleve, Naprosyn)
D. Labetolol (Normodyne)

A client newly prescribed esomeprazole for
gastroesophageal reflux disease (GERD) asks the
nurse how the medication will help. Which is the
best explanation to provide the client?
A
A. It will promote rapid tissue healing
B. It will increase gastric emptying
C. It will improve esophageal peristalsis
D. It will neutralize gastric secretions

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Institution
HESI Pharmacology
Course
HESI Pharmacology

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Uploaded on
January 23, 2026
Number of pages
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Written in
2025/2026
Type
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Contains
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