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NUR 376 – Pathophysiology Exam 1 (100 Q&As) | Cellular Injury, Immunity, Fluids, Electrolytes, ABGs | Concordia College St. Paul

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This fully updated and expert-verified study set includes 100 comprehensive Q&A-style questions and answers for NUR 376 – Nursing Pathophysiology, tailored for Exam 1 (2026) at Concordia College St. Paul. The document is designed for students seeking a focused and clinically relevant review of key foundational concepts in pathophysiology and their real-life application. Each question is directly linked to core topics tested in exams and board reviews, with clinical case-based rationales that reinforce critical thinking. Major topic areas include: Cellular Adaptation & Injury: Hypertrophy (physiologic and pathologic), atrophy, hyperplasia, metaplasia, apoptosis vs. necrosis, neoplasia (benign/malignant), and intracellular accumulations. Inflammation & Immunity: Acute vs. chronic inflammation, WBC response, cytokines, immune system function, hypersensitivities, autoimmune diseases (e.g., lupus), and HIV/AIDS pathology. Fluid & Electrolyte Balance: Role of RAAS, ADH, albumin, hydrostatic/oncotic pressure, third-spacing, types of edema, dehydration, and IV fluid therapy (hypertonic, isotonic, hypotonic). Electrolyte Imbalances: Clinical signs, ECG changes, and causes of hypo/hypernatremia, hypo/hyperkalemia, hypo/hypercalcemia, and hypo/hypermagnesemia. Acid-Base Balance & ABGs: Pathophysiology and compensatory mechanisms in metabolic and respiratory acidosis/alkalosis, interpretation of ABG values, and case-based applications of pH, PaCO₂, and HCO₃⁻. Buffer Systems & Hormonal Regulation: Bicarbonate, phosphate, and protein buffer systems, natriuretic peptides, and endocrine roles in homeostasis. This resource is ideal for: BSN students studying Pathophysiology, Medical-Surgical Nursing, or Adult Health Students preparing for NCLEX-RN, ATI, HESI, or institutional assessments Pre-nursing and allied health majors needing an in-depth physiological foundation Presented in a clinical context with updated terminology and test-aligned rationales, this is a go-to exam preparation guide. Keywords: pathophysiology, NUR 376, cellular injury, inflammation, immunity, HIV, apoptosis, necrosis, edema, RAAS, ADH, ABG, acid base balance, electrolyte imbalance, sodium, potassium, magnesium, calcium, IV fluids, NCLEX, nursing exam prep, Concordia College St. Paul

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NUR 376 Pathophysiology Exam 1 2026
Exam Questions with 100% Correct
Answers | Latest Update



Brian, age 28, began an aerobic exercise program 2 years ago. Brian now

competes in long-distance cycling events and considers himself to be an

endurance athlete who is in the "best shape of his life." An echocardiogram

reveals a slightly enlarged left ventricle. What cellular change or injury that

is best exemplified by the case scenario. - 🧠 ANSWER ✔✔Physiologic

hypertrophy

,An ADAPTIVE type of hypertrophy that occurs due to extensive exercise,

whereby the heart will create new blood vessel branches (angiogenesis)

and there is increased mitochondria, ATP, and actin/myosin filaments in the

muscle.

Recently, Karen learned that not only does HIV directly attack CD4 cells,

but the presence of the virus seems to activate pathways responsible for

programmed cell death in CD4 cells. Thus, HIV infection appears to

increase the rate of "suicide" for CD4 cells. - 🧠 ANSWER ✔✔Apoptosis


Define dysplasia - 🧠 ANSWER ✔✔Compared to normal cells, cells

demonstrating dysplasia are atypical in size and shape. Dysplasia does not

mean the cells are cancerous. However, some screening tests, such as the

Pap smear, examine tissues to determine if any cellular changes are taking

place. Any changes in the cells can then be monitored over time.

A biopsy of a skin lesion is conducted on Leann, a 48-year-old woman.

Biopsy results revealed proliferating cells that were well-differentiated and

resembled surrounding cells. The cells were contained within a well-defined

area. - 🧠 ANSWER ✔✔Benign neoplasia.

,Neoplasia is uncontrolled and unregulated cell growth. The mass of tissue

resulting is known as a "neoplasm." In a benign neoplasm, the cells do not

have the characteristics associated with malignancy. The cells, although

cancerous, are well-differentiated, meaning they resemble normal, mature

cells. The cells are also in a contained area and are unlikely to spread.

Miguel, a retired warehouse supervisor, had a myocardial infarction.

Further evaluation revealed he had significant blockage in his left

descending coronary artery. The blockage resulted in ischemia and cell

death for those cells served by the artery. - 🧠 ANSWER ✔✔Necrosis




Necrosis is premature cell death caused by cell injury. Necrosis differs from

apoptosis, in that the cellular destruction results from some form of trauma,

rather than genetic programming. May lead to GANGRENE which is when

dead tissue houses bacteria.

Julianne, who suffers from familial hypercholesterolemia, presents with

xanthomas. Xanthomas are excess cholesterol deposits, which appear as

yellow skin lesions. What cell process is this - 🧠 ANSWER ✔✔Intracellular

accumulation.



COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
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, Some disease processes stimulate intracellular accumulations of particles,

such as calcium, cholesterol, and triglycerides, glucose, among other

substances. In familial hypercholesterolemia, a genetic defect causes

decreased cellular uptake of cholesterol, resulting in high serum cholesterol

levels. Cholesterol deposits, known as xanthomas, may appear to form

under the skin.

Janae experienced a frightening ATV accident, in which her ATV flipped

over and she ended up catching a portion of her upper arm on a barbed

wire fence. Although Janae's injuries healed fully, enlarged, keloid scar

formations remain at the injury site. - 🧠 ANSWER ✔✔Hyperplasia




cell proliferation, known as hyperplasia, was stimulated as a result of her

injury. A keloid results from overgrowth of granulation tissue during the

wound repair process.

Hypertension that leads to workload on the left ventricle and thus

enlargement would be deemed? - 🧠 ANSWER ✔✔Pathological

hypertrophy.

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