nonmalignant enlargement of the prostate gland resul ng from increased prolifera on of
stromal and epithelial cells in the transi on zone -correct answers benign prosta c hyperplasia
relax smooth muscle in bladder neck/prostate to improve urine flow -correct answers alpha-1
adrenergic antagonists
tamsulosin -correct answers alpha-1
alfuzosin -correct answers alpha-1
doxazosin -correct answers alpha-1
terazosin -correct answers alpha-1
most uroselec ve alpha 1 blocker -correct answers tamsulosin - fewer BP effects
do not use before cataract surgery (IFIS risk) -correct answers alpha 1 blockers
alpha one blockers adverse effects -correct answers dizziness, orthosta c hypotension,
retrograde ejacula on
finasteride -correct answers 5-alpha reductase inhibitors
, dutasteride -correct answers 5-alpha reductase inhibitors
reduce DHT, prostate shrinkage -correct answers 5-alpha reductase inhibitors
combina on therapy of alpha one blocker and 5-ARI -correct answers moderate-severe
symptoms and enlarged prostate
5-ARIs adverse effects -correct answers sexual dysfunc on, depression, gynecomas a
women of child bearing age should not handle this due to teratogenicity -correct answers 5-ARIs
PDE-5 inhibitors -correct answers ED
sildenafil -correct answers PDE-5 inhibitors
tadalafil -correct answers PDE-5 inhibitors
vardenafil -correct answers PDE-5 inhibitors
avanafil -correct answers PDE-5 inhibitors
inhibits PDE-5 which increases cGMP to prolong smooth muscle relaxa on improving penile
blood flow; requires sexual s mula on to work -correct answers PDE-5 inhibitors
PDE-5 inhibitors contraindica ons -correct answers nitrates, alpha blockers, severe cardiac
disease
stromal and epithelial cells in the transi on zone -correct answers benign prosta c hyperplasia
relax smooth muscle in bladder neck/prostate to improve urine flow -correct answers alpha-1
adrenergic antagonists
tamsulosin -correct answers alpha-1
alfuzosin -correct answers alpha-1
doxazosin -correct answers alpha-1
terazosin -correct answers alpha-1
most uroselec ve alpha 1 blocker -correct answers tamsulosin - fewer BP effects
do not use before cataract surgery (IFIS risk) -correct answers alpha 1 blockers
alpha one blockers adverse effects -correct answers dizziness, orthosta c hypotension,
retrograde ejacula on
finasteride -correct answers 5-alpha reductase inhibitors
, dutasteride -correct answers 5-alpha reductase inhibitors
reduce DHT, prostate shrinkage -correct answers 5-alpha reductase inhibitors
combina on therapy of alpha one blocker and 5-ARI -correct answers moderate-severe
symptoms and enlarged prostate
5-ARIs adverse effects -correct answers sexual dysfunc on, depression, gynecomas a
women of child bearing age should not handle this due to teratogenicity -correct answers 5-ARIs
PDE-5 inhibitors -correct answers ED
sildenafil -correct answers PDE-5 inhibitors
tadalafil -correct answers PDE-5 inhibitors
vardenafil -correct answers PDE-5 inhibitors
avanafil -correct answers PDE-5 inhibitors
inhibits PDE-5 which increases cGMP to prolong smooth muscle relaxa on improving penile
blood flow; requires sexual s mula on to work -correct answers PDE-5 inhibitors
PDE-5 inhibitors contraindica ons -correct answers nitrates, alpha blockers, severe cardiac
disease
