MCB 2010 Exam 3 Questions With Complete Solutions
Please select all the TRUE statements about developing new
antimicrobial medications.
Most recently approved new medications are chemically
modified versions of existing medications.
Existing antimicrobial medications can often be improved by
chemically modifying them in the lab.
Developing a new antimicrobial medication is financially risky
for a company because target microbes may develop resistance.
What antimicrobial medications bind the 50S subunit?
Streptogramins, chloramphenicol, oxazolidones, lincosamides,
and macrolides all affect the large ribosomal subunit.
What antimicrobial medications bind the 30S subunit?
tetracyclines
glycylclines
aminoglycosides
image of an E (epsilometer) test.
Describe where MIC value can be seen
Which of the following antimicrobials target the bacterial
cytoplasmic membrane?
Daptomycin
Polymyxin B
,The distribution and metabolism of some antimicrobials can be
adversely affected by
different pH conditions in some areas of the body.
quick metabolism by the patient's enzymes.
the ability of the host to metabolize the medication quickly.
Which of the following antimicrobial medications inhibit
nucleic acid synthesis in bacteria?
Rifamycins
Metronidazole
Fluoroquinolones
Consider the figure below, which shows MIC results for
organism C against antibiotic P. The organism does not grow in
the tube containing 16 μg/mL of the antibiotic, and yet it might
still be considered resistant to the medication. Why is this so?
It is possible that the maximum safe level of this medication in
vivo is less than the MIC, so the antibiotic could not be used at
the indicated concentration.
antibotic
An antimicrobial drug naturally produced by a microorganism.
Breakthrough therapy
Drugs that offer great benefits over existing therapies for
treating serious diseases.
Chemotherapeutic agent
A chemical used to treat disease.
,Antimicrobial drug
A chemical used to treat microbial infections.
Few medications are effective against Mycobacterium
tuberculosis. Please check all the statements explaining why this
situation exists
M. tuberculosis has a slow generation time.
The cell wall of M. tuberculosis prevents entry of medications.
M. tuberculosis has developed resistance to many medications.
Explain the difference between MIC and MBC.
MIC is the minimum dose of an antimicrobial medication that
prevents the growth of an organism, while MBC is the minimum
dose of that medication that kills the organism.
Which step(s) in the figure below is/are targeted by antiviral
medications such as acyclovir, ribavirin, and AZT?
step with nucleic acid synthesis
, Please choose the class of antimicrobials that would have the
most selective toxicity.
Antimicrobials that inhibit cell wall synthesis.
(T/F) All antibiotics are made by fungi such
as Penicillium and Cephalosporium.
False
The four main categories of antifungal drugs
-macrolide polyenes
-azoles
-echinocandins
-flucytosine
The MIC is
Please select all the TRUE statements about developing new
antimicrobial medications.
Most recently approved new medications are chemically
modified versions of existing medications.
Existing antimicrobial medications can often be improved by
chemically modifying them in the lab.
Developing a new antimicrobial medication is financially risky
for a company because target microbes may develop resistance.
What antimicrobial medications bind the 50S subunit?
Streptogramins, chloramphenicol, oxazolidones, lincosamides,
and macrolides all affect the large ribosomal subunit.
What antimicrobial medications bind the 30S subunit?
tetracyclines
glycylclines
aminoglycosides
image of an E (epsilometer) test.
Describe where MIC value can be seen
Which of the following antimicrobials target the bacterial
cytoplasmic membrane?
Daptomycin
Polymyxin B
,The distribution and metabolism of some antimicrobials can be
adversely affected by
different pH conditions in some areas of the body.
quick metabolism by the patient's enzymes.
the ability of the host to metabolize the medication quickly.
Which of the following antimicrobial medications inhibit
nucleic acid synthesis in bacteria?
Rifamycins
Metronidazole
Fluoroquinolones
Consider the figure below, which shows MIC results for
organism C against antibiotic P. The organism does not grow in
the tube containing 16 μg/mL of the antibiotic, and yet it might
still be considered resistant to the medication. Why is this so?
It is possible that the maximum safe level of this medication in
vivo is less than the MIC, so the antibiotic could not be used at
the indicated concentration.
antibotic
An antimicrobial drug naturally produced by a microorganism.
Breakthrough therapy
Drugs that offer great benefits over existing therapies for
treating serious diseases.
Chemotherapeutic agent
A chemical used to treat disease.
,Antimicrobial drug
A chemical used to treat microbial infections.
Few medications are effective against Mycobacterium
tuberculosis. Please check all the statements explaining why this
situation exists
M. tuberculosis has a slow generation time.
The cell wall of M. tuberculosis prevents entry of medications.
M. tuberculosis has developed resistance to many medications.
Explain the difference between MIC and MBC.
MIC is the minimum dose of an antimicrobial medication that
prevents the growth of an organism, while MBC is the minimum
dose of that medication that kills the organism.
Which step(s) in the figure below is/are targeted by antiviral
medications such as acyclovir, ribavirin, and AZT?
step with nucleic acid synthesis
, Please choose the class of antimicrobials that would have the
most selective toxicity.
Antimicrobials that inhibit cell wall synthesis.
(T/F) All antibiotics are made by fungi such
as Penicillium and Cephalosporium.
False
The four main categories of antifungal drugs
-macrolide polyenes
-azoles
-echinocandins
-flucytosine
The MIC is
