NSG 533 Exam 2 Advanced Pharmacology
Questions and Verified Answers latest updated
Which of the following is a flaw in the monoamine hypothesis of depression?
A. Concentrations of neurotransmitters are reduced in the synaptic cleft
B. A switch to a different class of antidepressants does not improve response
C. Antidepressant response is associated with a therapeutic level of the medication D.
Antidepressant effects on neurotransmitters do not temporally correspond to
response. - D
A 26-year-old patient with a first episode of depression has been treated with
duloxetine A .................................................................... Error! Bookmark not defined.
B ..................................................................................................................................... 2
C ..................................................................................................................................... 2
D. 12 ............................................................................................................................... 3
60 mg twice daily for the past 4 months. The patient would like to discontinue treatment.
The patient should be told that they need at least _____full months of antidepressant
therapy after reaching full remission.
Which of the side effects of trazodone for the treatment of depression is most frequently
observed? A. Hematuria
, B. Delayed orgasm
C. Priapism
D. Orthostasis - D
A 46-year-old woman presents to the psychiatric outpatient clinic for follow-up treatment
of major depression. She is currently on paroxetine 10 mg at bedtime, which she started
taking 2 months ago when admitted to the psychiatric hospital for suicidal ideation.
During the interview, she says that she does not think the medication is working
because she is just as depressed as she was before taking the medication and has
recently started drinking eight to 10 beers daily to alleviate the depression. Before this
episode, she was sober for 4 years. Which of the following treatment strategies would
be the appropriate choice for this patient?
A. Stop the paroxetine and start nefazodone 100 mg po twice daily
B. Increase the dose of paroxetine to 20 mg po at bedtime
C. Stop the paroxetine and start duloxetine 20 mg/day
D. Continue the paroxetine at them same dose for a longer period of time to evaluate
whether she will res - B
An antidepressant that may be dangerous in overdose is
A. Mirtazapine
B. Amitriptyline
C. Fluoxetine
D. Escitalopram - B
A 28-year-old man with a history of depression has been taking sertraline 200 mg daily
for 12 weeks with no response. The patient has no other complaints. The physician
asks for your recommendation. The most reasonable recommendation would be to: A.
Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine - D
AS is an 18-year-old woman hospitalized for the fourth time for major depressive
disorder. On this occasion, AS was admitted for suicidal ideation. Her other symptoms
include loss of appetite, insomnia, decreased energy, increased agitation, and
anhedonia for the past 2 months. Although she did well her first semester of college, AS
"partied: a lot and broke up with a new boyfriend. Two months ago, AS refused to go
back to college after the winter holidays. She does not have any other medical
problems. AS's mother and grandfather have a history of bipolar illness, and her father
has a history of substance abuse. AS's symptoms meet the criteria for major depressive
disorder based upon the fact that she has:
Questions and Verified Answers latest updated
Which of the following is a flaw in the monoamine hypothesis of depression?
A. Concentrations of neurotransmitters are reduced in the synaptic cleft
B. A switch to a different class of antidepressants does not improve response
C. Antidepressant response is associated with a therapeutic level of the medication D.
Antidepressant effects on neurotransmitters do not temporally correspond to
response. - D
A 26-year-old patient with a first episode of depression has been treated with
duloxetine A .................................................................... Error! Bookmark not defined.
B ..................................................................................................................................... 2
C ..................................................................................................................................... 2
D. 12 ............................................................................................................................... 3
60 mg twice daily for the past 4 months. The patient would like to discontinue treatment.
The patient should be told that they need at least _____full months of antidepressant
therapy after reaching full remission.
Which of the side effects of trazodone for the treatment of depression is most frequently
observed? A. Hematuria
, B. Delayed orgasm
C. Priapism
D. Orthostasis - D
A 46-year-old woman presents to the psychiatric outpatient clinic for follow-up treatment
of major depression. She is currently on paroxetine 10 mg at bedtime, which she started
taking 2 months ago when admitted to the psychiatric hospital for suicidal ideation.
During the interview, she says that she does not think the medication is working
because she is just as depressed as she was before taking the medication and has
recently started drinking eight to 10 beers daily to alleviate the depression. Before this
episode, she was sober for 4 years. Which of the following treatment strategies would
be the appropriate choice for this patient?
A. Stop the paroxetine and start nefazodone 100 mg po twice daily
B. Increase the dose of paroxetine to 20 mg po at bedtime
C. Stop the paroxetine and start duloxetine 20 mg/day
D. Continue the paroxetine at them same dose for a longer period of time to evaluate
whether she will res - B
An antidepressant that may be dangerous in overdose is
A. Mirtazapine
B. Amitriptyline
C. Fluoxetine
D. Escitalopram - B
A 28-year-old man with a history of depression has been taking sertraline 200 mg daily
for 12 weeks with no response. The patient has no other complaints. The physician
asks for your recommendation. The most reasonable recommendation would be to: A.
Increase sertraline
B. Add fluoxetine
C. Switch to amitriptyline
D. Change to venlafaxine - D
AS is an 18-year-old woman hospitalized for the fourth time for major depressive
disorder. On this occasion, AS was admitted for suicidal ideation. Her other symptoms
include loss of appetite, insomnia, decreased energy, increased agitation, and
anhedonia for the past 2 months. Although she did well her first semester of college, AS
"partied: a lot and broke up with a new boyfriend. Two months ago, AS refused to go
back to college after the winter holidays. She does not have any other medical
problems. AS's mother and grandfather have a history of bipolar illness, and her father
has a history of substance abuse. AS's symptoms meet the criteria for major depressive
disorder based upon the fact that she has:
