BTCT301 PHARMACEUTICAL
BIOTECHNOLOGY
M.Sc. BT & MB Sem3
SMMPISR
, Topics Covered
• Unit 1 Weightage:25% Lectures:12
• History of the pharmaceutical industry, Biopharmaceuticals
and introduction to animal, plant and microbial based
pharmaceutical products. Expression hosts, recombinant
microbes as expression hosts for biopharmaceuticals,
Molecular Pharming
, Introduction
• Sources of Biopharmaceuticals:
• Several biopharmaceuticals are currently available.
• Most of the recombinant proteins available in the market
are produced either in recombinant Eschericia coli (E. coli
K12 ) or in recombinant mammalian cell lines- Chinese
hamster (a type of small rat) ovary strain K1 (CHO-K1).
• However Biopharmaceuticals are right now produced from
microbes, plants and animals.
, Microbes - Biopharmaceutical source
• E. coli as a source of recombinant, therapeutic proteins:
• Many microorganisms are attractive production systems or
sources for therapeutic proteins.
• Microorganisms can be cultured in large quantities,
inexpensively and in a short time, by standard methods of
fermentation. Production facilities can be constructed
anywhere in world, and the scale of production can be
varied as required.
BIOTECHNOLOGY
M.Sc. BT & MB Sem3
SMMPISR
, Topics Covered
• Unit 1 Weightage:25% Lectures:12
• History of the pharmaceutical industry, Biopharmaceuticals
and introduction to animal, plant and microbial based
pharmaceutical products. Expression hosts, recombinant
microbes as expression hosts for biopharmaceuticals,
Molecular Pharming
, Introduction
• Sources of Biopharmaceuticals:
• Several biopharmaceuticals are currently available.
• Most of the recombinant proteins available in the market
are produced either in recombinant Eschericia coli (E. coli
K12 ) or in recombinant mammalian cell lines- Chinese
hamster (a type of small rat) ovary strain K1 (CHO-K1).
• However Biopharmaceuticals are right now produced from
microbes, plants and animals.
, Microbes - Biopharmaceutical source
• E. coli as a source of recombinant, therapeutic proteins:
• Many microorganisms are attractive production systems or
sources for therapeutic proteins.
• Microorganisms can be cultured in large quantities,
inexpensively and in a short time, by standard methods of
fermentation. Production facilities can be constructed
anywhere in world, and the scale of production can be
varied as required.
