MOLECULAR BIOLOGY OF THE CELL, SEVENTH
J J J J J J
EDITION SOLUTION MANUAL J J
CHAPTER 1:CELLS AND GENOMES
J J J
1. ScientistsJdiscoverJmoreJthanJtenJthousandJnewJspeciesJofJlivingJorganismsJeveryJyear.J
WhatJisJsharedJbetweenJallJofJtheseJorganisms?
A. TheyJareJmadeJofJcells,JwhoseJnucleiJencloseJtheirJDNA.
B. TheyJobtainJtheirJenergyJfromJsunlight.
C. TheyJproduceJandJuseJadenosineJtriphosphateJ(ATP).
D. TheirJgenomeJcontainsJatJleastJ1000Jgenes.
E. AllJofJtheJabove.
2. AllJcellsJ…
A. haveJmembraneJtransportJproteins.
B. synthesizeJproteinsJonJtheJribosome.
C. replicateJtheirJgenomeJbyJDNAJpolymerization.
D. transcribeJtheirJgeneticJinformationJbyJRNAJpolymerization.
E. AllJofJtheJabove.
3. ImagineJaJsegmentJofJDNAJ(withinJaJgene)JencodingJaJcertainJamountJofJinformationJinJ
itsJnucleotideJsequence.JWhenJthisJsegmentJisJfullyJtranscribedJintoJmRNAJandJthenJtranslatedJi
ntoJprotein,JinJgeneral,J…
A. theJproteinJsequenceJwouldJcarryJmoreJinformationJcomparedJtoJtheJDNAJandJmRNAJ
sequences,JbecauseJitsJalphabetJhasJ20Jletters.
B. theJproteinJsequenceJwouldJcarryJlessJinformationJcomparedJtoJtheJDNAJandJmRNAJ
sequences,JbecauseJseveralJcodonsJcanJcorrespondJtoJoneJaminoJacid.
,2J|JPJaJgJe
C. theJamountJofJinformationJinJtheJmRNAJsequenceJisJlower,JbecauseJtheJmRNAJhasJ
beenJtranscribedJusingJonlyJoneJofJtheJDNAJstrandsJasJtheJtemplate.
D. theJamountJofJinformationJinJtheJmRNAJsequenceJisJhigher,JbecauseJseveralJmRNAJ
moleculesJcanJbeJtranscribedJfromJoneJDNAJmolecule.
4. WhichJofJtheJfollowingJprocessesJthatJhappensJinsideJaJcellJDOESJNOTJnormallyJrequireJ
consumptionJofJfreeJenergyJbyJtheJcell?
A. ReplicationJofJtheJgeneticJmaterial
B. ImportJofJnutrientsJfromJtheJenvironment
C. DiffusionJofJsmallJmoleculesJwithinJtheJcell
D. RegulationJofJgeneJexpression
E. SynthesisJofJenzymesJthatJcatalyzeJcellularJreactions
5. WhichJofJtheJfollowingJwouldJyouJNOTJexpectJtoJfindJinJaJbacterialJcell?
A. SwimmingJusingJflagella
B. HavingJaJcellJwallJaroundJtheJplasmaJmembrane
C. ATPJproductionJinJmitochondria
D. ProteinJproductionJonJtheJribosome
E. SexualJexchangeJofJDNAJwithJotherJbacteria
6. ToJtraceJfamilyJrelationshipsJbetweenJdistantlyJrelatedJorganismsJsuchJasJhumans,Jalgae,J
bacteria,JandJarchaea,JoneJshouldJcompareJtheirJgenomesJinJregionsJ…
A. thatJevolveJrapidly.
B. thatJhaveJaJhigherJmutationJrate.
C. thatJcodeJforJproteins.
D. whereJmutationsJareJhardlyJtolerated.
E. whereJmostJmutationsJareJselectivelyJneutral.
,3J|JPJaJgJe
7. LaboratoryJstrainsJofJtheJmodelJorganismJEscherichiaJcoliJthatJareJresistantJtoJantibioticsJ
areJveryJoftenJusedJinJresearchJlaboratoriesJasJwellJasJinJtheJbiotechnologyJindustry.JIfJculturesJofJ
suchJbacteriaJwereJallowedJtoJcontaminateJtheJenvironmentJuncontrollably,JitJisJpossibleJthatJatJso
meJpoint,JpathogenicJbacteriaJsuchJasJNeisseriaJmeningitidisJ(whichJcausesJmeningitisJandJcanJca
useJdeath,JespeciallyJinJchildren)JcouldJacquireJtheJsameJantibiotic-
resistanceJgene,JcausingJaJmeningitisJoutbreakJthatJisJdifficultJtoJtreat.JInJthisJscenario,JwhichJofJt
heJfollowingJmechanismsJisJaJmoreJlikelyJsourceJofJtheJantibiotic-
resistanceJgeneJinJN.Jmeningitidis?
A. RandomJnewJgeneJgeneration
B. IntragenicJmutation
C. GeneJduplication
D. DNAJsegmentJshuffling
E. HorizontalJgeneJtransfer
8. AJvirusJ…
A. isJaJtypeJofJcell.
B. hasJgeneticJmaterialJmadeJofJproteins.
C. canJonlyJinfectJaJsingleJhostJspecies.
D. canJactJasJaJvectorJforJgeneJtransfer.
E. cannotJpersistJinJitsJhostJforJmoreJthanJoneJcellJgeneration.
9. WhichJofJtheJfollowingJdoesJNOTJtypicallyJinvolveJhorizontalJgeneJtransfer?
A. SexualJreproductionJinJhumans
B. BacteriophageJinfectionJofJbacteria
C. TheJevolutionaryJhistoryJofJtheJeukaryoticJcell
D. TheJaccidentalJduplicationJofJaJsmallJregionJofJaJbacterialJchromosomeJfollowedJbyJ
cellJdivision
E. IntroductionJofJplasmidsJintoJbacteriaJinJaJlaboratory
10. GeneJduplicationJcanJgiveJriseJtoJhomologousJgenesJthatJareJpartJofJgeneJfamilies.JForJ
example,JthereJareJsixJactinJgenesJinJtheJgenomeJofJmostJmammalianJspecies.JInJhumans,Jthe
, 4J|JPJaJgJe
ACTBJgene,JwhichJencodesJaJcytoskeletalJactin,JisJexpressedJubiquitously,JwhileJACTC1JisJexpre
ssedJmainlyJinJcardiacJcells.JAlthoughJbacteriaJlackJtheJeukaryoticJcytoskeletalJorganization,JtheJ
bacterialJMreBJgeneJbearsJrecognizableJsequenceJsimilarityJtoJmammalianJactinJgenesJandJcodesJf
orJaJproteinJthatJisJsimilarJtoJactinJinJstructureJandJfunction.JWhichJofJtheJfollowingJstatementsJisJ
trueJaboutJtheseJgenes?
A. ACTBJisJhomologousJtoJACTC1JbutJnotJtoJMreB.
B. ACTBJisJorthologousJtoJACTC1JbutJnotJtoJMreB.
C. ACTBJisJparalogousJtoJACTC1JbutJnotJtoJMreB.
D. MreBJisJorthologousJtoJACTBJbutJnotJtoJACTC1.
E. ACTBJisJparalogousJtoJbothJACTC1JandJMreB.
11. OutJofJnearlyJ5000Jprotein-
codingJgeneJfamilies,JthereJisJaJsetJofJnearlyJ300JconservedJgeneJfamiliesJthatJareJfoundJinJspec
iesJfromJallJdomainsJofJlife.JWhenJoneJlooksJatJtheJgeneralJfunctionsJassignedJtoJtheseJgeneJfa
milies,JitJisJfoundJthatJ…
A. theJmajorityJofJthemJfunctionJinJcell-to-cellJsignaling.
B. theJmajorityJofJthemJareJpoorlyJcharacterized.
C. moreJthanJone-
thirdJofJthemJareJinvolvedJinJtranslationJorJaminoJacidJtransportJandJmetabolism.
D. moreJthanJone-
halfJofJtheJsharedJfamiliesJareJinvolvedJinJDNAJreplicationJandJtranscription.
E. NearlyJallJofJthemJareJinvolvedJinJenergyJproductionJandJcarbohydrateJmetabolism.
12. WhichJofJtheJfollowingJisJtrueJregardingJEscherichiaJcoli?
A. MostJofJourJunderstandingJaboutJmitosisJcomesJfromJstudiesJonJthisJmodelJorganism.
B. ItJisJaJrod-
shapedJbacteriumJthatJcanJonlyJgrowJinJtheJgutJofJhumansJandJotherJvertebrates
.
C. TwoJstrainsJofJE.JcoliJcanJdifferJbyJupJtoJ0.1%JinJtheirJgenomes.
D. E.JcoliJstrainJK-12JencodesJaboutJ4300Jproteins.
E. TheJE.JcoliJ(strainJK-12)JgenomeJisJaboutJ430JmillionJnucleotideJpairsJlong.