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Pharmacology NCLEX GI Drugs Review: Antacids, PPIs, H2 Blockers & Laxatives

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Master your NCLEX pharmacology knowledge of gastrointestinal medications with this targeted question bank. This review covers antacids, proton pump inhibitors (PPIs), H2 receptor blockers, laxatives, anti-diarrheals, and anti-ulcer drugs. Each question includes detailed rationales explaining correct and incorrect answers, reinforcing key nursing interventions, patient teaching points, and drug safety considerations. Ideal for nursing students preparing for the NCLEX-RN or NCLEX-PN, as well as nurses seeking to refresh their GI pharmacology skills.

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PHARMACOLOGY NCLEX GI DRUGS: GI
AGENTS AND ANTIULCER EXAM QUESTIONS
WITH CORRECT ANSWERS LATEST


Which side effects should the nurse explain to the male client who is prescribed
cimetidine?



1. The medication can cause indigestion and heartburn.



2. The medication can cause impotence and gynecomastia.



3. The medication can cause insomnia and hypervigilance.



4. The medication can cause Zollinger-Ellison syndrome. --ANSWER--
ANSWER:

2. Cimetidine (Tagamet) is an H2 blocker. Over time, Tagamet can cause males
to become impotent, have decreased libido, and have breast development
(gynecomastia)



RATIONALE WHY THESE AREN'T THE ANSWERS:

1. Cimetidine (Tagamet), an H2 blocker, is used to treat indigestion and
heartburn (pyrosis).


Page | 1

,3. Tagamet can cause lethargy and somnolence, not insomnia and
hypervigilance.



4. Tagamet is used to treat Zollinger-Ellison syndrome, a syndrome
characterized by hypersecretion of gastric acid and the formation of peptic
ulcers.



The nurse is preparing to administer esomeprazole. Which intervention should
the nurse implement? Select all that apply.



1. Order an infusion pump for the client.



2. Elevate the client's head of the bed.



3. Check the client's ID with the medication administration record (MAR).



4. Check for allergies to cephalosporin.



5. Ask the client his or her date of birth. --ANSWER--ANSWER:

2. The head of the bed is elevated for the client to be able to swallow the
medication.



Page | 2

,3. The nurse must check the MAR with the client's ID band to ensure the correct
client is receiving the medication.



5. The Joint Commission requires that two patient identifiers be used to
determine the "right patient." Most health-care facilities use the client's name
and date of birth as these identifiers.



RATIONALE WHY THESE AREN'T THE ANSWERS:

1. Esomeprazole (Nexium), a PPI, is an oral medication. An IV pump is not
needed.



4. Esomeprazole (Nexium) is a PPI, not a cephalosporin. The cephalosporins are
a class of antibiotics.



The home health-care nurse is caring for a male client diagnosed with a hiatal
hernia and reflux. Which data indicates the medication therapy is effective?



1. The client takes the antacid 1 hour before and 3 hours after a meal.



2. The client reports indigestion after eating a large meal.



3. The client states that he did not wake up with heartburn during the night.




Page | 3

, 4. The client has lost 3 pounds in the past 2 weeks. --ANSWER--ANSWER:

3. This indicates an improvement in symptoms and that the medication is
effective.

MEDICATION MEMORY JOGGER: The nurse determines the effectiveness
of a medication by assessing for the symptoms, or lack thereof, for which the
medication was prescribed.



RATIONALE WHY THESE AREN'T THE ANSWERS:

1. This indicates client compliance with the dosing regimen for antacids, not
that the medication is effective.



2. The return of symptoms indicates the medication is not effective.



4. Losing weight would not indicate that a medication for hiatal hernia is
effective.




The client reporting "acid" when lying down at night asks the nurse if there is
any medication that might help. Which statement is the nurse's best response?



1. "There are no medications to treat this problem, but losing weight will
sometimes help the symptoms."


Page | 4

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