NUR 521 ADV PHARM EXAM 1 Newest 2026 Complete
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DOC for parkinsons disease - how does it work? How long
does it take to work? How would you know its working?
What should you teach your pt? - ANSWER-
Levodopa/Carbidopa
How it works: oincreases dopamine synthesis
O After uptake in brain, converts to active form of
dopamine restoring balance between dopamine and
acetylcholine
How long does it take to work: full therapeutic response
can take a few months
Patient education:
· Takes weeks to months to start working
· Avoid high protein meals to minimize abrupt loss of
effects
· N & V minimized if taken with low-fat, low-protein foods
(fruit)
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· Drug induced movement disorders
· Notify provider for excessive cardiac stimulation
· Orthostatic Hypotension: get up slowly
· Drug induced psychosis: may need clozapine
What would you prescribe in addition to Sinemet if the
patient experiences acute loss effect? - ANSWER-drug
that prolongs levodopas half life (entacapone)
Or
Direct-acting dopamine agonist
· Centrally Acting Alpha 2 Agonist
What are these drugs used for? How do they work? What
teaching should be provided to the patient? - ANSWER--
similar to adrenergic antagonists
-prevent the activations of peripheral adrenergic recptors
by mechanisms that do not involve direct interaction with
peripheral receptors.
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-they work in the CNS to reduce outflow of impulses to
sympathetic nerves
-patient education: take dose at bedtime to minimize
sedation during day. Dont stop abruptly (rebound htn can
occur). Patch application education. High abuse potential
with cocaine or opiod abuse.
What important patient education should be taught when
starting a patient on Prazosin? - ANSWER--First dose
effect: take first dose at bedtime.
-S/s of orthostatic and how to avoid
Use and MOA of adrenergic agonists - ANSWER-· Drugs
activate adrenergic receptors by 4 mechanisms that are
direct or indirect
O Bind directly on receptor
O Promote norepinephrine release
O Inhibit norepinephrine reuptake
O Inhibit norepinephrine inactivation
How does epi work? What response would occur in a pt
when treated with epi? - ANSWER-o Epinephrine can
activate all four subtypes of adrenergic receptors. As a