NUR 521 ADV PHARM EXAM 4 Newest 2026 Complete
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Enbrel Indications: - ANSWER-* Rheumatoid arthritis,
psoriatic arthritis, or ankylosing spondylitis;
* Plaque psoriasis
* Polyarticular juvenile idiopathic arthritis in children
Enbrel CI: - ANSWER-* Hypersensitivity to drug or
ingredient, granulomatosis w/polyangiitis
Enbrel Precautions: - ANSWER-* Chronic or recurrent
infection, >65 yo, uncontrolloed diabetes mellitus, TB,
HBV, malignancy
Enbrel Patient Education: - ANSWER-* Delivery:
Etanercept is injected under the skin
* Monitoring: Hepatitis B serology incl. HBsAg at baseline;
TB at baseline, then periodically
Enbrel Evaluation: - ANSWER-* Side Effects:
* Monitor for fever, chills, flu symptoms, pale skin, easy
bruising or bleeding; pain, redness or swelling at injection
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site; signs of lymphoma including fever, night sweats,
weight loss, swollen glands; signs of TB
Tofacitinib (Xeljanz) MOA: - ANSWER-* Inhibits janus-
associated kinases (JAK) 1, 2, and 3, leading to disruption
of cytokine and growth factor signaling pathways
* DMARD
Xeljanz BBW: - ANSWER-* Risk of infection,
malignancies, cardiovascular events, thrombosis;
* Weigh risk/benefit during pregnancy and female pts of
reproductive potential; avoid breastfeeding
Xeljanz Pharmacokinetics: - ANSWER-* Metabolized in
the liver, excreted in the urine
Xeljanz Indications: - ANSWER-* Rheumatoid arthritis
Xeljanz CI: - ANSWER-* Hypersensitivity to drug or
ingredient
* Baseline Hgb <9
* Lymphocytes <500
* Baseline ANC <1000
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* Active infection
* Hepatic impairment
Xeljanz Precaution: - ANSWER-* Renal, hepatic
impairment
* Chronic or recurrent infection
* Active or latent TB
* Chronic lung dz
* HBV
* HCV
* Smokers
Xeljanz Patient Education: - ANSWER-Monitoring:
hepatitis panel, CBC w/diff, TB test, LFT's
Xeljanz Evaluation: - ANSWER-* Side Effects:
-- SOB
-- Nausea
-- Vomiting
-- Cold sweat
-- Weakness on one side of body
-- Slurred speech
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-- Skin rash
-- Shingles
-- Increased BP
-- Fever
-- Headache
-- N/V/D
Allopurinol (Zyloprim) MOA: - ANSWER-* Inhibits xanthine
oxidase, interfering w/ conversion of hypoxanthine and
xanthine to uric acid
* Xanthine Oxidase Inhibitor
Zyloprim Safety: - ANSWER-* BUN/Cr at baseline then
periodically
* LFT's during early tx if hepatic disease
Zyloprim Pharmacokinetics: - ANSWER-* Metabolized in
the liver, excreted in the urine primarily
* Drug Interactions: Delays the metabolism of warfarin,
azathioprine, theophylline
Zyloprim Indications: - ANSWER-* Gout