Erythrocyte Kinetics

Erythrocyte Kinetics
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I What happens to the red cell in each given ↑

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Deficiency of peripheral proteins
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scenario? ↑
Functions in the transportation to
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various locations in the cell, signaling and
Deficiency of integral proteins maintaining cell shape and structure.
Integral proteins are important in
channeling or transporting molecules They temporarily bonds with the cell
across the membrane. membrane which allows cells to
coordinate and communicate using
They act as cell receptors, and responsible networks of proteins and reactions.
for cell adhesion.
Spectrin is the most abundant peripheral
Red cell is important in the Red cell membrane proteins of red blood cells.
membrane to accomplish the task of
transporting salts and nutrients. It is the major cytoskeleton protein of
erythrocytes.
With the proteins that span or embedded
in it; it achieves its transport role. With the deficiency, it will lead to loss of
erythrocyte surface area, which
Integral proteins is responsible for red cell produces spherical RBCs, this may lead to
and membrane homeostasis. hereditary spherocytosis.
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Any deficiency can affect the attachment I
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of the cytoskeleton to the membrane I

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integral domain. I
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This may result to loss of surface area and I
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leads to spheroid, osmotically fragile cells I

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selectively trapped in the spleen. I
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The alteration of cell surface area has an ! i
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effect on the ability of cells to survive. !
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