What are the general rules or trends of maturation? IL-3: Interleukin-3
The overall trend is from larger to smaller size; round, T-cell-derived, pluripotent and hematopoietic factor
fine nucleus to dark, segmented nucleus; increasing required for survival and proliferation of
cytoplasm; no granules to primary (azurophilic) granules hematopoietic progenitor cells.
to specific (secondary) granules.
Erythropoietin (EPO)
What are the different growth factors that affect Has a potential therapeutic applications: post
hematopoietic? autologous hematopoietic stem cell transplant.
FLT3 ligand After blood loss, large amounts of the hormone EPA
Works synergistically with (IL -3) interleukin-3, flood the hematopoietic system in the bone marrow.
GMCSF, and other.
M-CSF Macrophage colony-stimulating factor
Cytokines to promote early hematopoietic stem cell Regulates the proliferation, differentiation, and
proliferation and differentiation. it is a growth functional activation of monocytes, macrophages
factor for hematopoietic progenitor cell. and their hematopoietic progenitors.
GM-CSF What are the possible conditions of the bone marrow
Includes expression of specific genes that stimulate that will not support hematopoiesis.
hematopoietic stem cell differentiation to the common Bone marrow is the primary site of hematopoiesis at
myeloid progenitor. birth and throughout life.
Promote early HTC proliferation and differentiation. Aplastic anemia
This do not support hematopoiesis because it
KIF Ligand or stem cell factor is primarily a failure of the bone marrow to
A type of cytokine and a type of growth factor. produce blood cells.
We know that hematopoiesis
It causes blood stem cells to change into different
main rate is production of
types of blood cells and increases the number and
cellular components of blood
action of these cells in the blood.
and blood plasma.
The overall trend is from larger to smaller size; round, T-cell-derived, pluripotent and hematopoietic factor
fine nucleus to dark, segmented nucleus; increasing required for survival and proliferation of
cytoplasm; no granules to primary (azurophilic) granules hematopoietic progenitor cells.
to specific (secondary) granules.
Erythropoietin (EPO)
What are the different growth factors that affect Has a potential therapeutic applications: post
hematopoietic? autologous hematopoietic stem cell transplant.
FLT3 ligand After blood loss, large amounts of the hormone EPA
Works synergistically with (IL -3) interleukin-3, flood the hematopoietic system in the bone marrow.
GMCSF, and other.
M-CSF Macrophage colony-stimulating factor
Cytokines to promote early hematopoietic stem cell Regulates the proliferation, differentiation, and
proliferation and differentiation. it is a growth functional activation of monocytes, macrophages
factor for hematopoietic progenitor cell. and their hematopoietic progenitors.
GM-CSF What are the possible conditions of the bone marrow
Includes expression of specific genes that stimulate that will not support hematopoiesis.
hematopoietic stem cell differentiation to the common Bone marrow is the primary site of hematopoiesis at
myeloid progenitor. birth and throughout life.
Promote early HTC proliferation and differentiation. Aplastic anemia
This do not support hematopoiesis because it
KIF Ligand or stem cell factor is primarily a failure of the bone marrow to
A type of cytokine and a type of growth factor. produce blood cells.
We know that hematopoiesis
It causes blood stem cells to change into different
main rate is production of
types of blood cells and increases the number and
cellular components of blood
action of these cells in the blood.
and blood plasma.
