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Question 1
A nurse is providing teaching to a client who has a new prescription for diclofenac. Which of the
following instructions should the nurse include?
A) Take the medication on an empty stomach to increase absorption.
B) Limit fluid intake to 1,000 mL per day while taking this drug.
C) Administer the medication with food or a glass of milk.
D) Take this medication at bedtime to prevent daytime drowsiness.
E) Avoid eating dairy products while taking this medication.
Correct Answer: C) Administer the medication with food or a glass of milk.
Rationale: Diclofenac is a Nonsteroidal Anti-inflammatory Drug (NSAID). A common and
significant side effect of NSAIDs is gastric irritation and potential peptic ulcer formation.
Taking the medication with food or milk creates a physical barrier and helps buffer the
stomach lining, thereby minimizing gastrointestinal distress and irritation.
Question 2
A nurse is preparing to administer esomeprazole to a client who has a gastric ulcer. At which of
the following times should the nurse plan to administer the medication?
A) 15 minutes after the client finishes a meal.
B) At the same time the client eats their largest meal.
C) 60 minutes before a meal.
D) Immediately before the client goes to sleep.
E) Only when the client reports active epigastric pain.
Correct Answer: C) 60 minutes before a meal.
Rationale: Esomeprazole is a Proton Pump Inhibitor (PPI). These medications are most
effective when taken on an empty stomach, approximately 30 to 60 minutes before food
intake. Food can significantly decrease the absorption rate of PPIs, and the medication
needs time to inhibit the proton pumps before they are stimulated by a meal.
Question 3
A nurse is providing discharge teaching to a client who has a new prescription for furosemide.
Which of the following instructions should the nurse include?
A) Restrict potassium-rich foods like bananas and spinach.
B) Take the medication immediately before bedtime.
C) Rise slowly when transitioning from a sitting or lying position.
D) Notify the provider if you experience increased thirst.
E) Limit weight monitoring to once per week.
Correct Answer: C) Rise slowly when transitioning from a sitting or lying position.
Rationale: Furosemide is a potent loop diuretic that can cause a rapid decrease in blood
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volume, leading to orthostatic hypotension. Clients should be taught to change positions
slowly to prevent dizziness and falls. Other key teachings include eating high-potassium
foods (due to potassium wasting), taking the dose early in the day to prevent nocturia, and
checking weight daily to monitor for fluid shifts.
Question 4
A nurse is caring for a client who is receiving methylprednisolone. Which of the following
laboratory values should the nurse plan to monitor?
A) Serum calcium.
B) Serum glucose.
C) Prothrombin time (PT).
D) Amylase.
E) Platelet count.
Correct Answer: B) Serum glucose.
Rationale: Methylprednisolone is a corticosteroid. Glucocorticoids increase circulating
blood glucose levels by stimulating gluconeogenesis and decreasing the peripheral uptake
of glucose. This often results in "steroid-induced hyperglycemia," requiring frequent
monitoring of blood sugar levels, especially in diabetic clients.
Question 5
A nurse is evaluating the effectiveness of epoetin alfa therapy for a client who has chronic kidney
disease. Which of the following laboratory values indicates a therapeutic effect?
A) A decrease in serum creatinine.
B) An increase in serum iron.
C) An increase in hemoglobin.
D) A decrease in white blood cell count.
E) A decrease in blood urea nitrogen (BUN).
Correct Answer: C) An increase in hemoglobin.
Rationale: Epoetin alfa is a synthetic form of erythropoietin that stimulates the bone
marrow to produce red blood cells. It is used to treat anemia associated with chronic
kidney disease or chemotherapy. A rise in hemoglobin levels indicates that the medication is
effectively stimulating erythropoiesis.
Question 6
A client is receiving a continuous IV infusion of heparin for the treatment of venous thrombosis.
Which of the following laboratory tests should the nurse monitor to titrate the dose?
A) Prothrombin time (PT).
B) International Normalized Ratio (INR).
C) Activated partial thromboplastin time (aPTT).
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D) Bleeding time.
E) D-dimer.
Correct Answer: C) Activated partial thromboplastin time (aPTT).
Rationale: The aPTT is the standard laboratory test used to monitor the effectiveness of
heparin therapy and adjust the infusion rate. The goal is typically to maintain the aPTT at
1.5 to 2.5 times the normal control value. PT and INR are used specifically for monitoring
warfarin therapy.
Question 7
A nurse is caring for a client who has tuberculosis and a new prescription for rifampin. Which of
the following statements by the client indicates an understanding of the teaching?
A) "I should expect my skin to turn slightly yellow."
B) "I will take this medication with a high-fat meal."
C) "I shouldn't wear my soft contact lenses because they will become discolored."
D) "I will stop the medication once my cough goes away."
E) "I will limit my water intake to prevent fluid retention."
Correct Answer: C) "I shouldn't wear my soft contact lenses because they will become
discolored."
Rationale: Rifampin causes a harmless but distinct red-orange discoloration of all body
fluids, including urine, sweat, saliva, and tears. This can permanently stain soft contact
lenses. Clients should also be taught to take the medication on an empty stomach with a full
glass of water and to monitor for hepatotoxicity (not nephrotoxicity).
Question 8
A nurse is teaching a client who has gout and a new prescription for allopurinol. Which of the
following explanations should the nurse provide?
A) "This medication dissolves existing uric acid crystals in the joints."
B) "This medication decreases the production of uric acid."
C) "This medication increases the excretion of uric acid by the kidneys."
D) "This medication acts as a powerful anti-inflammatory for acute attacks."
E) "This medication works by numbing the nerves in the affected joint."
Correct Answer: B) "This medication decreases the production of uric acid."
Rationale: Allopurinol is a xanthine oxidase inhibitor used for the long-term management of
gout. It works by inhibiting the enzyme responsible for producing uric acid, thereby
lowering serum urate levels and preventing future gouty attacks and joint damage. It is not
used for acute attacks; colchicine or NSAIDs are preferred for acute inflammation.
Question 9
A nurse is preparing to administer IV acyclovir to a client. Which of the following actions should
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the nurse take?
A) Infuse the medication rapidly over 15 minutes.
B) Limit the client's fluid intake during the infusion.
C) Assess the client for an increase in serum creatinine.
) Monitor the client for signs of hyperglycemia.
E) Administer the medication only when the client has a fever.
Correct Answer: C) Assess the client for an increase in serum creatinine.
Rationale: IV acyclovir can cause reversible nephrotoxicity due to the precipitation of
acyclovir crystals in the renal tubules. The nurse must monitor BUN and creatinine levels
and ensure the client is well-hydrated during and after the infusion to "flush" the kidneys
and prevent renal damage.
Question 10
A nurse is reviewing the laboratory results for a client who is taking warfarin following
orthopedic surgery. Which of the following results should the nurse report to the provider
immediately?
A) INR 2.5.
B) aPTT 35 seconds.
C) INR 5.2.
D) Prothrombin time 18 seconds.
E) Platelet count 250,000/mm³.
Correct Answer: C) INR 5.2.
Rationale: For a client on warfarin, the therapeutic INR range is generally 2.0 to 3.0. An
INR of 5.2 is significantly above the therapeutic range and represents a critical value that
puts the client at a high risk for spontaneous hemorrhage. The nurse should withhold the
dose, notify the provider, and prepare to administer Vitamin K if ordered.
Question 11
A nurse is assessing a client who is taking acetazolamide for glaucoma. Which of the following
findings should the nurse identify as an adverse effect of this medication?
A) Hyperkalemia.
B) Electrolyte imbalance.
C) Increased intraocular pressure.
D) Hypertension.
E) Weight gain.
Correct Answer: B) Electrolyte imbalance.
Rationale: Acetazolamide is a carbonic anhydrase inhibitor that acts as a diuretic. It
promotes the renal excretion of sodium, potassium, and bicarbonate. Therefore, the nurse