COMLEX LEVEL 1 EXAM 2025 FULL LENGTH
PRACTICE QUESTIONS AND COMPLETELY
SOLVED ANSWERS
◉ MOA + Use: Oxandrolone. Answer: MOA: Anabolic-Androgenic
steroid
Use: Treatment of severe burns
ADE: Testicular atrophy
◉ MOA: Sirolimus. Answer: mTOR inhibitor
-binds FKBP to inhibit mTOR
inhibits proliferation of T cells in response to IL2
◉ MOA of tacrolimus. Answer: Calcineurin inhibitor via binding with
intracellular FKBP-12 protein which
impairs IL-2
use: transplant rejection
◉ MOA: Danazol. Answer: Synthetic steroid
,Decreases production of LH and FSH
◉ What is the most common cause of death in patients with Polycystic
Kidney Disease?. Answer: Cardiac disease
◉ Elevation of which hormone can confirm menopause in women of
appropriate age?. Answer: FSH
◉ What are the positive immunohistochemical stains for
leiomyosarcoma?. Answer: Desmin
Vimentin
H-Caldesmon
Actin
◉ Which renal pathology is associated with Broad, waxy casts?.
Answer: Advanced Chronic renal failure
◉ What drug is commonly used for Neuropathic pain?. Answer:
Amitriptyline (TCA)
ADE of note: strong muscarinic blocking properties = urinary retention
and tachycardia
,◉ Location of high risk HPV strain infections. Answer: basal layer of
the squamous epithelium of the ectocervix
◉ MOA of acyclovir. Answer: Competitively inhibits DNA polymerase,
chain termination occurs
tx for genital herpes
◉ Describe histological appearance of leydig cell tumor. Answer: large
polygonal cells with vacuolated cytoplasm and Reinke Crystals (found
in the interstitum of the testes) = rod shaped intracytoplasmic crystal
inclusions with rounded ends
◉ What is the first line treatment for gonorrhea?. Answer: Ceftriaxone
** remember to treat for this and chlamydia ( add azithromycin or
doxycycline)
◉ Where do you see Anti--microsomal antibodies?. Answer:
Hashimoto's thyroiditis
◉ What are the signs and symptoms associated with Paget's disease of
the breast?. Answer: crusting, eczema like reaction, fissures around the
areola
, associated with an invasive DUCTAL carcinoma
◉ MOA of tamoxifen?. Answer: Antagonist at breast
agonist at bone, uterus
ADE: increased risk thromboembolic events (esp with smoking) and
endometrial cancer
◉ leiomyoma. Answer: AKA FIBROIDS
benign tumor of smooth muscle commonly found in the uterus
If symptomatic: menorrhagia, dysmenorrhea, dyspaurenia. can cause
pregnancy loss
◉ What is associated with lesions of the trochlear nerve?. Answer:
Lesions of the trochlear nerve (cranial nerve IV) result in dysfunction of
the superior oblique muscle and an inability to depress the eye, leading
to diplopia when the patient tries to look downward.
◉ What results from a lesion to the Amygdala?
Describe location. Answer: Kluver-Bucy Syndrome
PRACTICE QUESTIONS AND COMPLETELY
SOLVED ANSWERS
◉ MOA + Use: Oxandrolone. Answer: MOA: Anabolic-Androgenic
steroid
Use: Treatment of severe burns
ADE: Testicular atrophy
◉ MOA: Sirolimus. Answer: mTOR inhibitor
-binds FKBP to inhibit mTOR
inhibits proliferation of T cells in response to IL2
◉ MOA of tacrolimus. Answer: Calcineurin inhibitor via binding with
intracellular FKBP-12 protein which
impairs IL-2
use: transplant rejection
◉ MOA: Danazol. Answer: Synthetic steroid
,Decreases production of LH and FSH
◉ What is the most common cause of death in patients with Polycystic
Kidney Disease?. Answer: Cardiac disease
◉ Elevation of which hormone can confirm menopause in women of
appropriate age?. Answer: FSH
◉ What are the positive immunohistochemical stains for
leiomyosarcoma?. Answer: Desmin
Vimentin
H-Caldesmon
Actin
◉ Which renal pathology is associated with Broad, waxy casts?.
Answer: Advanced Chronic renal failure
◉ What drug is commonly used for Neuropathic pain?. Answer:
Amitriptyline (TCA)
ADE of note: strong muscarinic blocking properties = urinary retention
and tachycardia
,◉ Location of high risk HPV strain infections. Answer: basal layer of
the squamous epithelium of the ectocervix
◉ MOA of acyclovir. Answer: Competitively inhibits DNA polymerase,
chain termination occurs
tx for genital herpes
◉ Describe histological appearance of leydig cell tumor. Answer: large
polygonal cells with vacuolated cytoplasm and Reinke Crystals (found
in the interstitum of the testes) = rod shaped intracytoplasmic crystal
inclusions with rounded ends
◉ What is the first line treatment for gonorrhea?. Answer: Ceftriaxone
** remember to treat for this and chlamydia ( add azithromycin or
doxycycline)
◉ Where do you see Anti--microsomal antibodies?. Answer:
Hashimoto's thyroiditis
◉ What are the signs and symptoms associated with Paget's disease of
the breast?. Answer: crusting, eczema like reaction, fissures around the
areola
, associated with an invasive DUCTAL carcinoma
◉ MOA of tamoxifen?. Answer: Antagonist at breast
agonist at bone, uterus
ADE: increased risk thromboembolic events (esp with smoking) and
endometrial cancer
◉ leiomyoma. Answer: AKA FIBROIDS
benign tumor of smooth muscle commonly found in the uterus
If symptomatic: menorrhagia, dysmenorrhea, dyspaurenia. can cause
pregnancy loss
◉ What is associated with lesions of the trochlear nerve?. Answer:
Lesions of the trochlear nerve (cranial nerve IV) result in dysfunction of
the superior oblique muscle and an inability to depress the eye, leading
to diplopia when the patient tries to look downward.
◉ What results from a lesion to the Amygdala?
Describe location. Answer: Kluver-Bucy Syndrome
