PRACTICE PAPER FOR 2026 SUMMER EXAMS
Oxford Cambridge and RSA
2025 Predicted Paper
A Level Biology A
H420/01 Biological processes
Time allowed: 2 hours 15 minutes
You can use:
• a scientific or graphical calculator
• a ruler (cm/mm)
* H
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be
given for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 100.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 20 pages.
ADVICE
• Read each question carefully before you start your answer.
SOLE Property of Tyrion's
, PRACTICE PAPER FOR 2026 SUMMER EXAMS
Section A
Answer all the questions. Write your answer in the box provided. Each question is worth 1 mark.
1. Which of the following statements about proteins is correct?
A. Proteins are always globular molecules.
B. Peptide bonds are formed by hydrolysis reactions.
C. Tertiary structure is stabilized by hydrogen, ionic, and disulfide bonds.
D. Only fibrous proteins have a quaternary structure.
Your answer: [1]
2. Enzymes function as biological catalysts by:
A. Increasing the activation energy required for reactions.
B. Stabilizing the enzyme-substrate complex.
C. Binding to non-specific substrates.
D. Altering the equilibrium constant of the reaction.
Your answer: [1]
3. The phospholipid bilayer of the plasma membrane:
A. Is impermeable to all substances.
B. Allows only hydrophobic molecules to diffuse freely.
C. Contains intrinsic proteins that facilitate active transport.
D. Is rigid due to cholesterol molecules.
Your answer: [1]
, PRACTICE PAPER FOR 2026 SUMMER EXAMS
4. Which organelle is correctly matched to its function?
A. Mitochondrion – Photosynthesis
B. Lysosome – Protein synthesis
C. Smooth ER – Lipid synthesis
D. Ribosome – DNA replication
Your answer: [1]
5. The diagram shows part of a DNA molecule. Which bonds are broken during DNA
replication?
A. Phosphodiester bonds
B. Hydrogen bonds
C. Ionic bonds
D. Glycosidic bonds
Your answer: [1]
6. Which process occurs during transcription?
A. DNA polymerase adds nucleotides to a DNA template.
B. RNA polymerase synthesizes mRNA.
C. Ribosomes bind to mRNA.
D. tRNA molecules pair with codons.
Your answer: [1]
Oxford Cambridge and RSA
2025 Predicted Paper
A Level Biology A
H420/01 Biological processes
Time allowed: 2 hours 15 minutes
You can use:
• a scientific or graphical calculator
• a ruler (cm/mm)
* H
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be
given for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 100.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 20 pages.
ADVICE
• Read each question carefully before you start your answer.
SOLE Property of Tyrion's
, PRACTICE PAPER FOR 2026 SUMMER EXAMS
Section A
Answer all the questions. Write your answer in the box provided. Each question is worth 1 mark.
1. Which of the following statements about proteins is correct?
A. Proteins are always globular molecules.
B. Peptide bonds are formed by hydrolysis reactions.
C. Tertiary structure is stabilized by hydrogen, ionic, and disulfide bonds.
D. Only fibrous proteins have a quaternary structure.
Your answer: [1]
2. Enzymes function as biological catalysts by:
A. Increasing the activation energy required for reactions.
B. Stabilizing the enzyme-substrate complex.
C. Binding to non-specific substrates.
D. Altering the equilibrium constant of the reaction.
Your answer: [1]
3. The phospholipid bilayer of the plasma membrane:
A. Is impermeable to all substances.
B. Allows only hydrophobic molecules to diffuse freely.
C. Contains intrinsic proteins that facilitate active transport.
D. Is rigid due to cholesterol molecules.
Your answer: [1]
, PRACTICE PAPER FOR 2026 SUMMER EXAMS
4. Which organelle is correctly matched to its function?
A. Mitochondrion – Photosynthesis
B. Lysosome – Protein synthesis
C. Smooth ER – Lipid synthesis
D. Ribosome – DNA replication
Your answer: [1]
5. The diagram shows part of a DNA molecule. Which bonds are broken during DNA
replication?
A. Phosphodiester bonds
B. Hydrogen bonds
C. Ionic bonds
D. Glycosidic bonds
Your answer: [1]
6. Which process occurs during transcription?
A. DNA polymerase adds nucleotides to a DNA template.
B. RNA polymerase synthesizes mRNA.
C. Ribosomes bind to mRNA.
D. tRNA molecules pair with codons.
Your answer: [1]
