HESI RN AdvANcEd PHARmAcology ExAm Study
guIdE 2026 – comPlEtE PRActIcE QuEStIoNS,
vERIfIEd RAtIoNAlES, dRug clASS BREAkdowN,
NuRSINg PHARmAcology REvIEw & HESI RN tESt
SuccESS mAtERIAlS
HESI RN Advanced Pharmacology Practice Exam
Question 1:
Which of the following medications is classified as an ACE inhibitor?
A) Amlodipine
B) Lisinopril
C) Metoprolol
D) Losartan
Correct Option: B) Lisinopril
Rationale:
Lisinopril is an ACE inhibitor used primarily in the treatment of hypertension and heart failure.
Amlodipine is a calcium channel blocker, Metoprolol is a beta-blocker, and Losartan is an
angiotensin receptor blocker.
Question 2:
What is the primary use of Warfarin?
A) To reduce cholesterol levels
B) To prevent thromboembolic events
C) To treat hypertension
D) To manage diabetes
Correct Option: B) To prevent thromboembolic events
Rationale:
Warfarin is an anticoagulant primarily used to prevent the formation of blood clots in conditions
such as atrial fibrillation and deep vein thrombosis. It does not reduce cholesterol or directly
manage blood pressure or diabetes.
, Question 3:
Which of the following laboratory tests is essential to monitor while a patient is on
Amiodarone therapy?
A) Platelet count
B) Liver function tests
C) Thyroid function tests
D) Creatinine level
Correct Option: C) Thyroid function tests
Rationale:
Amiodarone can affect thyroid function, leading to either hypo- or hyperthyroidism. Regular
monitoring of thyroid levels is crucial. Although liver function tests and creatinine levels may
also be monitored, they are less directly related to Amiodarone therapy.
Question 4:
A patient is prescribed Digoxin. Which of the following symptoms may indicate Digoxin
toxicity?
A) Nausea and vomiting
B) Increased appetite
C) Weight gain
D) Hypotension
Correct Option: A) Nausea and vomiting
Rationale:
Symptoms of Digoxin toxicity include nausea, vomiting, visual disturbances, and arrhythmias.
Increased appetite and weight gain are not typical signs of toxicity, though hypotension may
occur as a side effect.
Question 5:
What is the mechanism of action of beta-blockers?
A) Increase heart rate
guIdE 2026 – comPlEtE PRActIcE QuEStIoNS,
vERIfIEd RAtIoNAlES, dRug clASS BREAkdowN,
NuRSINg PHARmAcology REvIEw & HESI RN tESt
SuccESS mAtERIAlS
HESI RN Advanced Pharmacology Practice Exam
Question 1:
Which of the following medications is classified as an ACE inhibitor?
A) Amlodipine
B) Lisinopril
C) Metoprolol
D) Losartan
Correct Option: B) Lisinopril
Rationale:
Lisinopril is an ACE inhibitor used primarily in the treatment of hypertension and heart failure.
Amlodipine is a calcium channel blocker, Metoprolol is a beta-blocker, and Losartan is an
angiotensin receptor blocker.
Question 2:
What is the primary use of Warfarin?
A) To reduce cholesterol levels
B) To prevent thromboembolic events
C) To treat hypertension
D) To manage diabetes
Correct Option: B) To prevent thromboembolic events
Rationale:
Warfarin is an anticoagulant primarily used to prevent the formation of blood clots in conditions
such as atrial fibrillation and deep vein thrombosis. It does not reduce cholesterol or directly
manage blood pressure or diabetes.
, Question 3:
Which of the following laboratory tests is essential to monitor while a patient is on
Amiodarone therapy?
A) Platelet count
B) Liver function tests
C) Thyroid function tests
D) Creatinine level
Correct Option: C) Thyroid function tests
Rationale:
Amiodarone can affect thyroid function, leading to either hypo- or hyperthyroidism. Regular
monitoring of thyroid levels is crucial. Although liver function tests and creatinine levels may
also be monitored, they are less directly related to Amiodarone therapy.
Question 4:
A patient is prescribed Digoxin. Which of the following symptoms may indicate Digoxin
toxicity?
A) Nausea and vomiting
B) Increased appetite
C) Weight gain
D) Hypotension
Correct Option: A) Nausea and vomiting
Rationale:
Symptoms of Digoxin toxicity include nausea, vomiting, visual disturbances, and arrhythmias.
Increased appetite and weight gain are not typical signs of toxicity, though hypotension may
occur as a side effect.
Question 5:
What is the mechanism of action of beta-blockers?
A) Increase heart rate
