م7:44 2024/4/2 NR 283 Pathophysiology-Final Exam Concept Review (Version 1)
NR 283 Final Exam Concept Review / NR283 Pathophysiology Final Exam Study Guide (Latest):
Pathophysiology: Chamberlain
(Complete solutions and resources for the course exam)
NR 283 Pathophysiology
Final Exam Concept Review
***For all previous content covered on previous exams, please consult your previous concept review
sheets. This is not an all-inclusive list for topics to be covered. Please be sure to consult your syllabus and
learning plan. This is a comprehensive final.
***Be sure to cover pathophysiology, etiology, clinical manifestations, nursing considerations, diagnostic
tests for the following topics:
Endocrine
SIADH- Syndrome of Inappropriate Diuretic Hormone Too much ADH (antidiuretic hormone )
secretion leads to water intoxication and hyponatremia
Causes include trauma, stroke, malignancies (often in the lungs or pancreas), medications, and stress
S/S include signs of fluid volume overload, changes in level of consciousness and mental status changes,
weight gain, hypertension, tachycardia, anorexia, nausea, vomiting, hyponatremia, concentrated urine,
decreased urine output, serum osmolality decreased
Nursing considerations include monitoring vital signs and cardiac and neurological status, providing a
safe environment, particularly for the patient with changes in level of consciousness or mental status,
monitoring intake and output and weight daily; monitoring fluid and electrolyte balance, monitoring
serum and urine osmolality; restriction of fluids
DI (Diabetes Insipidus)- Kidney tubules fail to reabsorb water
Etiology includes stroke or trauma or may be idiopathic
S/S include excretion of large amounts of dilute urine, polydipsia, dehydration (decreased skin turgor and
dry mucous membranes), inability to concentrate urine, increased urine output, urine very dilute, Low
urinary specific gravity, fatigue, muscle pain and weakness, headache, postural hypotension that may
progress to vascular collapse without rehydration, tachycardia, hypernatremia
Nursing Considerations: monitor vital signs and neurological and cardiovascular status, provide a safe
environment, particularly for the patient with postural hypotension; monitor electrolyte levels and for
signs of dehydration; maintain patient intake of adequate fluids; monitor intake and ouput, weight, serum
osmolality and specific gravity of urine; instruct the patient to avoid foods and/or liquids that produce
diuresis
Hyperthyroidism- Too much thyroid hormone (T3 and T4) Characterized by an increased rate of body
metabolism
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, م7:44 2024/4/2 NR 283 Pathophysiology-Final Exam Concept Review (Version 1)
Common cause is Graves’ disease, also known as toxic diffuse goiter
S/S include: personality changes such as irritability, agitation and mood swings, nervousness and fine
tremors of the hands, heat intolerance, weight loss, smooth, soft skin and hair, palpitations, cardiac
dysrhythmias such as tachycardia or atrial fibrillation, diarrhea, protruding eyeballs (exophthalmos) may
be present, diaphoresis (sweating), hypertension, enlarged thyroid gland (goiter)
Nursing Considerations: Provide adequate rest, provide a cool and quiet environment, provide a high-
calorie diet, obtain daily weight, avoid administration of stimulants, administer sedatives as prescribed,
administer antithyroid medications, administer blood pressure medication for tachycardia, prepare for
thyroidectomy if prescribed
Hypothyroidism- Hyposecretion of thyroid hormones (T3 and T4) Characterized by a decreased rate of
body metabolism
Causes: autoimmune disease, treatment for hyperthyroidism, radiation therapy, thyroid surgery, certain
medications
S/S: lethargy, fatigue, weakness, muscle aches, paresthesias, intolerance to cold, weight gain, dry skin and
hair and loss of body hair, bradycardia, constipation, generalized puffiness and edema around the eyes
and face (myxedema), forgetfulness and loss of memory, menstrual disturbances, cardiac enlargement,
tendency to develop heart failure, goiter may or may not be present
Hyperparathyroidism- Hypersecretion of parathyroid hormone (PTH)
Causes: Tumor, Hyperplasia, Genetics; secondary causes-severe calcium or vitamin D deficiency, chronic
kidney failure
S/S: Hypercalcemia and hypophosphatemia, fatigue and muscle weakness, skeletal pain and tenderness,
bone deformities that result in pathological fractures, anorexia, nausea, vomiting, epigastric pain, weight
loss, constipation, hypertension, cardiac dysrhythmias, renal stones
Nursing Considerations: Monitor vital signs, particularly blood pressure; monitor for cardiac
dysrhythmias, monitor for intake and output and for signs of renal stones, monitor skeletal pain, move the
patient slowly and carefully; encourage fluid intake, administer furosemide (Lasix) as prescribed to lower
calcium levels, administer phosphates, which interfere with calcium reabsorption as prescribed,
administer calcitonin as prescribed to decrease the skeletal calcium release and increase renal excretion of
calcium, monitor calcium and phosphorus levels, prepare the patient for parathyroidectomy as prescribed
Hypoparathyroidism-Hyposecretion of parathyroid hormone (PTH)
Can occur following a thyroidectomy because of removal of parathyroid tissue
S/S: Hypocalcemia and hyperphosphatemia, numbness and tingling in the face, muscle cramps and
cramps in the abdomen or extremities, positive Trousseau’s and Chvostek’s sign, signs of overt tetany
such as bronchospasm, laryngospasm, carpopedal spasm, dysphagia, photophobia, cardiac dysrhythmias,
seizures; hypotension, anxiety, irritability, depression
Nursing Considerations: Monitor vital signs, monitor for signs of hypocalcemia and tetany, initiate
seizure precautions, place a tracheostomy set, oxygen and suctioning equipment at bedside, prepare to
administer calcium gluconate intravenously for hypocalcemia, provide a high-calcium, low-phosphorus
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, م7:44 2024/4/2 NR 283 Pathophysiology-Final Exam Concept Review (Version 1)
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, م7:44 2024/4/2 NR 283 Pathophysiology-Final Exam Concept Review (Version 1)
Most commonly caused by an adenoma
S/S: Symptoms related to hypokalemia, hypernatremia, and hypertension; headache, fatigue, muscle
weakness, nocturia, polydipsia, polyuria, paresthesias; visual changes; low urine specific gravity and
increased urinary aldosterone level; elevated serum aldosterone levels
Nursing Considerations: Monitor vital signs, particulary blood pressure; monitor for signs of
hypokalemia and hypernatremia; monitor intake and output and urine for specific gravity; Spironolactone
(Aldactone) may be prescribed to promote fluid balance and control hypertension; this is a potassium-
sparing diuretic and aldosterone antagonist, and patients need to be monitored for hyperkalemia,
particularly those with impaired renal function or excessive potassium intake; administer potassium
supplements as prescribed; prepare the patient for adrenalectomy; maintain sodium restriction, as
prescribed, preoperatively; administer glucocorticoids preoperatively, as prescribed, to prevent adrenal
hypofunction; monitor the patient for adrenal insufficiency postoperatively; instruct the patient regarding
the need for glucocorticoid therapy following adrenalectomy; instruct the patient about the need to wear a
Medic-Alert bracelet
Pheochromocytoma-Catecholamine-producing tumor usually found in the adrenal medulla, but extra
adrenal locations include the chest, bladder, abdomen, and brain; typically is benign tumor but can be
malignant
Excessive epinephrine and norepinephrine secreted
S/S: paroxysmal or sustained hypertension, severe headaches, palpitations, flushing and profuse
diaphoresis, pain in the chest or abdomen with nausea and vomiting, heat intolerance, weight loss,
tremors
Complications: hypertensive crisis, hypertensive retinopathy and nephropathy, cardiac enlargement,
dysrhythmias, heart failure, myocardial infarction, increased platelet aggregation, and stroke; death can
occur from shock, stroke, renal failure, dysrhythmias, or dissecting aortic aneurysm
Nursing Considerations: Monitor vital signs particularly blood pressure and heart rate; monitor for
hypertensive crisis; monitor for complications that can occur with hypertensive crisis, such as stroke,
cardiac dysrhythmias, myocardial infarction; prepare to administer antihypertensive agents to control
hypertension; monitor serum glucose level; promote rest and a nonstressful environment; provide diet
high in calories, vitamins, and minerals; prepare for an adrenalectomy
It is important to avoid stimuli that can precipitate a hypertensive crisis, such as increased abdominal
pressure and vigorous abdominal palpation
Diabetes Mellitus (DM)- A group of diseases characterized by hyperglycemia due to defects in insulin
secretion, insulin action, or both
Normally, a certain amount of glucose circulates in the blood.
Major sources of glucose are absorption of ingested food in the GI tract and formation of glucose by the
liver from food substances
Diabetes is especially prevalent in the elderly; as many as 50% of people older than 65 years of age has
some degree of glucose intolerance. People 65 years and older account for almost 40% of people with
diabetes.
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NR 283 Final Exam Concept Review / NR283 Pathophysiology Final Exam Study Guide (Latest):
Pathophysiology: Chamberlain
(Complete solutions and resources for the course exam)
NR 283 Pathophysiology
Final Exam Concept Review
***For all previous content covered on previous exams, please consult your previous concept review
sheets. This is not an all-inclusive list for topics to be covered. Please be sure to consult your syllabus and
learning plan. This is a comprehensive final.
***Be sure to cover pathophysiology, etiology, clinical manifestations, nursing considerations, diagnostic
tests for the following topics:
Endocrine
SIADH- Syndrome of Inappropriate Diuretic Hormone Too much ADH (antidiuretic hormone )
secretion leads to water intoxication and hyponatremia
Causes include trauma, stroke, malignancies (often in the lungs or pancreas), medications, and stress
S/S include signs of fluid volume overload, changes in level of consciousness and mental status changes,
weight gain, hypertension, tachycardia, anorexia, nausea, vomiting, hyponatremia, concentrated urine,
decreased urine output, serum osmolality decreased
Nursing considerations include monitoring vital signs and cardiac and neurological status, providing a
safe environment, particularly for the patient with changes in level of consciousness or mental status,
monitoring intake and output and weight daily; monitoring fluid and electrolyte balance, monitoring
serum and urine osmolality; restriction of fluids
DI (Diabetes Insipidus)- Kidney tubules fail to reabsorb water
Etiology includes stroke or trauma or may be idiopathic
S/S include excretion of large amounts of dilute urine, polydipsia, dehydration (decreased skin turgor and
dry mucous membranes), inability to concentrate urine, increased urine output, urine very dilute, Low
urinary specific gravity, fatigue, muscle pain and weakness, headache, postural hypotension that may
progress to vascular collapse without rehydration, tachycardia, hypernatremia
Nursing Considerations: monitor vital signs and neurological and cardiovascular status, provide a safe
environment, particularly for the patient with postural hypotension; monitor electrolyte levels and for
signs of dehydration; maintain patient intake of adequate fluids; monitor intake and ouput, weight, serum
osmolality and specific gravity of urine; instruct the patient to avoid foods and/or liquids that produce
diuresis
Hyperthyroidism- Too much thyroid hormone (T3 and T4) Characterized by an increased rate of body
metabolism
about:blank 1/37
, م7:44 2024/4/2 NR 283 Pathophysiology-Final Exam Concept Review (Version 1)
Common cause is Graves’ disease, also known as toxic diffuse goiter
S/S include: personality changes such as irritability, agitation and mood swings, nervousness and fine
tremors of the hands, heat intolerance, weight loss, smooth, soft skin and hair, palpitations, cardiac
dysrhythmias such as tachycardia or atrial fibrillation, diarrhea, protruding eyeballs (exophthalmos) may
be present, diaphoresis (sweating), hypertension, enlarged thyroid gland (goiter)
Nursing Considerations: Provide adequate rest, provide a cool and quiet environment, provide a high-
calorie diet, obtain daily weight, avoid administration of stimulants, administer sedatives as prescribed,
administer antithyroid medications, administer blood pressure medication for tachycardia, prepare for
thyroidectomy if prescribed
Hypothyroidism- Hyposecretion of thyroid hormones (T3 and T4) Characterized by a decreased rate of
body metabolism
Causes: autoimmune disease, treatment for hyperthyroidism, radiation therapy, thyroid surgery, certain
medications
S/S: lethargy, fatigue, weakness, muscle aches, paresthesias, intolerance to cold, weight gain, dry skin and
hair and loss of body hair, bradycardia, constipation, generalized puffiness and edema around the eyes
and face (myxedema), forgetfulness and loss of memory, menstrual disturbances, cardiac enlargement,
tendency to develop heart failure, goiter may or may not be present
Hyperparathyroidism- Hypersecretion of parathyroid hormone (PTH)
Causes: Tumor, Hyperplasia, Genetics; secondary causes-severe calcium or vitamin D deficiency, chronic
kidney failure
S/S: Hypercalcemia and hypophosphatemia, fatigue and muscle weakness, skeletal pain and tenderness,
bone deformities that result in pathological fractures, anorexia, nausea, vomiting, epigastric pain, weight
loss, constipation, hypertension, cardiac dysrhythmias, renal stones
Nursing Considerations: Monitor vital signs, particularly blood pressure; monitor for cardiac
dysrhythmias, monitor for intake and output and for signs of renal stones, monitor skeletal pain, move the
patient slowly and carefully; encourage fluid intake, administer furosemide (Lasix) as prescribed to lower
calcium levels, administer phosphates, which interfere with calcium reabsorption as prescribed,
administer calcitonin as prescribed to decrease the skeletal calcium release and increase renal excretion of
calcium, monitor calcium and phosphorus levels, prepare the patient for parathyroidectomy as prescribed
Hypoparathyroidism-Hyposecretion of parathyroid hormone (PTH)
Can occur following a thyroidectomy because of removal of parathyroid tissue
S/S: Hypocalcemia and hyperphosphatemia, numbness and tingling in the face, muscle cramps and
cramps in the abdomen or extremities, positive Trousseau’s and Chvostek’s sign, signs of overt tetany
such as bronchospasm, laryngospasm, carpopedal spasm, dysphagia, photophobia, cardiac dysrhythmias,
seizures; hypotension, anxiety, irritability, depression
Nursing Considerations: Monitor vital signs, monitor for signs of hypocalcemia and tetany, initiate
seizure precautions, place a tracheostomy set, oxygen and suctioning equipment at bedside, prepare to
administer calcium gluconate intravenously for hypocalcemia, provide a high-calcium, low-phosphorus
about:blank 2/37
, م7:44 2024/4/2 NR 283 Pathophysiology-Final Exam Concept Review (Version 1)
about:blank 3/37
, م7:44 2024/4/2 NR 283 Pathophysiology-Final Exam Concept Review (Version 1)
Most commonly caused by an adenoma
S/S: Symptoms related to hypokalemia, hypernatremia, and hypertension; headache, fatigue, muscle
weakness, nocturia, polydipsia, polyuria, paresthesias; visual changes; low urine specific gravity and
increased urinary aldosterone level; elevated serum aldosterone levels
Nursing Considerations: Monitor vital signs, particulary blood pressure; monitor for signs of
hypokalemia and hypernatremia; monitor intake and output and urine for specific gravity; Spironolactone
(Aldactone) may be prescribed to promote fluid balance and control hypertension; this is a potassium-
sparing diuretic and aldosterone antagonist, and patients need to be monitored for hyperkalemia,
particularly those with impaired renal function or excessive potassium intake; administer potassium
supplements as prescribed; prepare the patient for adrenalectomy; maintain sodium restriction, as
prescribed, preoperatively; administer glucocorticoids preoperatively, as prescribed, to prevent adrenal
hypofunction; monitor the patient for adrenal insufficiency postoperatively; instruct the patient regarding
the need for glucocorticoid therapy following adrenalectomy; instruct the patient about the need to wear a
Medic-Alert bracelet
Pheochromocytoma-Catecholamine-producing tumor usually found in the adrenal medulla, but extra
adrenal locations include the chest, bladder, abdomen, and brain; typically is benign tumor but can be
malignant
Excessive epinephrine and norepinephrine secreted
S/S: paroxysmal or sustained hypertension, severe headaches, palpitations, flushing and profuse
diaphoresis, pain in the chest or abdomen with nausea and vomiting, heat intolerance, weight loss,
tremors
Complications: hypertensive crisis, hypertensive retinopathy and nephropathy, cardiac enlargement,
dysrhythmias, heart failure, myocardial infarction, increased platelet aggregation, and stroke; death can
occur from shock, stroke, renal failure, dysrhythmias, or dissecting aortic aneurysm
Nursing Considerations: Monitor vital signs particularly blood pressure and heart rate; monitor for
hypertensive crisis; monitor for complications that can occur with hypertensive crisis, such as stroke,
cardiac dysrhythmias, myocardial infarction; prepare to administer antihypertensive agents to control
hypertension; monitor serum glucose level; promote rest and a nonstressful environment; provide diet
high in calories, vitamins, and minerals; prepare for an adrenalectomy
It is important to avoid stimuli that can precipitate a hypertensive crisis, such as increased abdominal
pressure and vigorous abdominal palpation
Diabetes Mellitus (DM)- A group of diseases characterized by hyperglycemia due to defects in insulin
secretion, insulin action, or both
Normally, a certain amount of glucose circulates in the blood.
Major sources of glucose are absorption of ingested food in the GI tract and formation of glucose by the
liver from food substances
Diabetes is especially prevalent in the elderly; as many as 50% of people older than 65 years of age has
some degree of glucose intolerance. People 65 years and older account for almost 40% of people with
diabetes.
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