MN 553 Unit 9 Quiz/MN 553 Unit 9 Quiz

MN 553 Unit 9 Quiz



Question 1

Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:

A need to monitor drugs metabolized by 2D6 for toxicity

Increased dosages needed of drugs metabolized by 2D6, such as the selective

serotonin reuptake inhibitors

Decreased conversion of codeine to morphine by CYP 2D6

The need for lowered dosages of drugs, such as beta blockers

Question 2

Rifampin is a nonspecific CYP450 inducer that may:

Lead to toxic levels of rifampin and must be monitored closely

Cause toxic levels of drugs, such as oral contraceptives, when coadministered

Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic

failure

Cause nonspecific changes in drug metabolism

Question 3

Inhibition of P-glycoprotein by a drug such as quinidine may lead to:

Decreased therapeutic levels of quinidine

Increased therapeutic levels of quinidine

Decreased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for

absorption and elimination

Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for

absorption and elimination

Question 4