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CLS 2026 Exam Questions (120+) with Answers – NURS400 | American Heart Association | Bradycardia, ROSC, Amiodarone

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This ACLS 2026 study guide contains over 120 exam-style multiple choice questions and answers, based on the ACLS Provider Manual (AHA, 2015 edition) and designed for healthcare students and professionals preparing for ACLS certification. It follows the Advanced Cardiovascular Life Support (NURS400) curriculum commonly offered at institutions such as the American Heart Association Training Center and major nursing schools across the U.S., and is suitable for exam preparation in nursing (BSN, MSN), paramedicine, physician assistant (PA), and emergency medicine programs. The material comprehensively covers high-yield topics such as bradycardia and its pharmacological management (e.g. atropine, dopamine), ventricular fibrillation and tachycardia protocols, return of spontaneous circulation (ROSC), post-cardiac arrest care, cardiovascular pharmacology (including epinephrine, amiodarone, and lidocaine), CPR performance standards, airway management including endotracheal and IO routes, and synchronized cardioversion energy levels. Each question is followed by a verified answer and explanation with clinical reasoning and references to specific page numbers from the official ACLS Provider Manual (2015 AHA Guidelines). The guide emphasizes evidence-based practice and is designed to align with current AHA certification exams and Nursing Board licensing requirements. Ideal for: – Nursing students (BSN, MSN, DNP) – Paramedic and EMT students – Physician Assistant students – Medical students in emergency medicine rotations – ACLS recertification candidates – Health professionals preparing for AHA-aligned ACLS exams Keywords: ACLS 2026, NURS400, American Heart Association, ACLS exam questions, ACLS verified answers, cardiac arrest, ROSC, epinephrine dose, synchronized cardioversion, amiodarone protocol, bradycardia treatment, tachycardia management, ACLS drug dosages, PEA causes, CPR guidelines, post-cardiac arrest care, ACLS 2015 guidelines, ACLS Provider Manual, emergency pharmacology, endotracheal drugs, ACLS nursing exam

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ACLS Study Guide 2026 Exam
Questions and Verified Answers
| Already Graded A+


Which of the following statements about about the science of CPR is NOT

correct in regards to the 2015 AHA guidelines?

a) a rate of 100 to 120 chest compressions per minute

b) a compression depth of at least 2 inches in adults?

c) switch compressor about every 5 minutes

d) chest compression fraction of at least 60% but ideally greater than 80 %

,e) allow complete chest recoil after each compression - 🧠 ANSWER ✔✔c -

switch compressor about every 2 minutes or sooner if fatigued

page 173

When administering epinephrine to a patient in cardiac arrest, the MAIN

desired effect is:·

A: vasoconstriction, which improves coronary and cerebral perfusion.·

B: beta-1 receptor stimulation, which increases cardiac contractility.· C:

coronary artery dilation, which decreases the myocardial workload.·

D: bronchodilation, which facilitates positive-pressure ventilation. - 🧠

ANSWER ✔✔answer is A;


Reason: Epinephrine stimulates alpha and beta receptors. However, it is

used during cardiac arrest because of its vasopressor effects that result

from stimulation of alpha-1 receptors. In conjunction with high-quality CPR,

epinephrine's vasoconstrictive effects improve coronary and cerebral

perfusion, thus keeping these organs viable until the underlying cardiac

dysrhythmia can be terminated

A 54-year-old woman is pulseless and apneic. Your partner and an

emergency medical responder are performing well-coordinated CPR. After

,2 minutes of CPR, the cardiac monitor reveals coarse ventricular fibrillation.

You should:·

A: deliver a single shock and immediately resume CPR.·

B: shock the patient three times with 360 monophasic joules.·

C: defibrillate at once and then reassess the rhythm and pulse.·

D: assess for a carotid pulse for no longer than 10 seconds. - 🧠 ANSWER

✔✔answer is A;


Reason: A single shock (360 monophasic joules or the biphasic equivalent)

should be administered to the patient with V-Fib or pulseless V-Tach

cardiac arrest. Immediately following this single shock, begin or resume

CPR, starting with chest compressions. Assessing the patient's cardiac

rhythm and pulse immediately following defibrillation causes an

unnecessary delay in CPR, and delays in CPR have been directly linked to

poor patient outcomes. Most patients who are defibrillated—especially if

their arrest interval is prolonged—remain in V-Fib/pulseless V-Tach or

convert to another non-perfusing rhythm (ie, asystole, PEA). Either way,

the patient is still in cardiac arrest and needs immediate CPR. After 2

minutes of CPR, reassess the patient's rhythm, and if necessary, a pulse (if



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, an organized cardiac rhythm appears), and repeat defibrillation (single

shock) if indicated, followed immediately by CPR.

Your first action after establishing return of spontaneous circulation (ROSC)

in a patient—regardless of his or her arrest rhythm and duration—is to

assess the patient's ________________________.

a) ventilatory status

b) cardiac status

c) level of consciousness


d) none of the above - 🧠 ANSWER ✔✔Answer is A




Your first action after establishing return of spontaneous circulation (ROSC)

in a patient—regardless of his or her arrest rhythm and duration—is to

assess the patient's ventilatory status.

During the ________________ cycles of CPR, vascular access can be

obtained, cardiac drugs can be administered, and the patient's airway can

be secured with an advanced device if necessary. It is absolutely critical to

minimize interruptions in chest compressions; if you must interrupt

compressions, do so for no longer than ____ seconds.

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