NURS 615 exam 1 Version A& B 2026, ||Verified
Exam!!! Maryville University nursing exam questions,
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Exam!!!
Drugs that are receptor agonists may demonstrate what
property?
1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and
drug action - ANSWER-3. Desensitization or
downregulation with continuous use
Drugs that are receptor antagonists, such as beta
blockers, may cause:
1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs
4. An exaggerated response to competitive drug agonists -
ANSWER-2. An exaggerated response if abruptly
discontinued
Factors that affect gastric drug absorption include:
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1. Liver enzyme activity
2. Protein-binding properties of the drug molecule
3. Lipid solubility of the drug
4. Ability to chew and swallow - ANSWER-3. Lipid
solubility of the drug
Drugs administered via IV:
1. Need to be lipid soluble in order to be easily absorbed
2. Begin distribution into the body immediately
3. Are easily absorbed if they are nonionized
4. May use pinocytosis to be absorbed - ANSWER-2.
Begin distribution into the body immediately
When a medication is added to a regimen for a synergistic
effect, the combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug
individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual -
ANSWER-2. Greater than the sum of the effects of each
drug individually
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Which of the following statements about bioavailability is
true?
1. Bioavailability issues are especially important for drugs
with narrow therapeutic
ranges or sustained-release mechanisms.
2. All brands of a drug have the same bioavailability.
3. Drugs that are administered more than once a day have
greater bioavailability than
drugs given once daily.
4. Combining an active drug with an inert substance does
not affect bioavailability. - ANSWER-1. Bioavailability
issues are especially important for drugs with narrow
therapeutic
ranges or sustained-release mechanisms.
Which of the following statements about the major
distribution barriers (blood-brain or fetal-placental) is
true?
1. Water soluble and ionized drugs cross these barriers
rapidly.
2. The blood-brain barrier slows the entry of many drugs
into and from brain cells.
3. The fetal-placental barrier protects the fetus from drugs
taken by the mother.
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4. Lipid-soluble drugs do not pass these barriers and are
safe for pregnant women. - ANSWER-2. The blood-brain
barrier slows the entry of many drugs into and from brain
cells
Drugs are metabolized mainly by the liver via phase I or
phase II reactions. The purpose of both of
these types of reactions is to:
1. Inactivate prodrugs before they can be activated by
target tissues
2. Change the drugs so they can cross plasma
membranes
3. Change drug molecules to a form that an excretory
organ can excrete
4. Make these drugs more ionized and polar to facilitate
excretion - ANSWER-3. Change drug molecules to a form
that an excretory organ can excrete
Once they have been metabolized by the liver, the
metabolites may be:
1. More active than the parent drug
2. Less active than the parent drug
3. Totally "deactivated" so they are excreted without any
effect