ONS ONCC CHEMO RENEWAL EXAM 2026
WITH 100% ACCURATE ANSWERS
1. TW is a 62-year-old female recently diagnosed with lymphoma. She
received rituximab, cyclophosphamide, vincristine, doxorubicin, and
prednisone (RCHOP). She did not receive any GCSF after chemotherapy.
One week after her chemotherapy, she was admitted for febrile
neutropenia. The physician asks if it is okay for her to receive GCSF after
each chemotherapy. As the pharmacist, you recommend...
She should receive GCSF within 24 hours of completion of
chemotherapy
She should receive GCSF at least 24 hours after completing
chemotherapy
She should not receive GCSF
2. Which statement accurately describes the mechanism of action of
Cytotoxic Antibiotic Antineoplastic Drugs?
They bind to specific receptors on the cell membrane to induce
apoptosis.
They directly destroy cancer cells by causing cell lysis.
They disrupt DNA synthesis by inhibiting the formation of new
DNA strands.
They interact with DNA to create cross-links and strand breaks,
leading to cell death.
3. Describe the significance of monitoring LVEF in patients receiving
chemotherapy with pertuzumab and trastuzumab.
Monitoring LVEF is only necessary if the patient experiences
symptoms.
, Monitoring LVEF is crucial to assess the risk of cardiotoxicity
and to make informed decisions about continuing or
withholding treatment.
Monitoring LVEF is irrelevant for patients on chemotherapy.
Monitoring LVEF is only required before the first cycle of
chemotherapy.
4. If a hospital implements the NCCN Older Adult Oncology Guidelines,
what changes might they make to their chemotherapy treatment
protocols for older patients?
They may incorporate comprehensive geriatric assessments to
tailor treatment plans.
They may eliminate the use of chemotherapy for older patients.
They may reduce the number of chemotherapy sessions for all
patients.
They may only focus on younger patients' treatment protocols.
5. What are the key points to consider when managing combination
therapy in chemotherapy?
Cost of treatment, patient preference, and drug availability.
Patient age, drug interactions, and treatment duration.
Potential toxicity, monitoring guidelines, and significant signs
and symptoms.
Type of cancer, stage of disease, and patient demographics.
6. What does RDI stand for in the context of chemotherapy treatment?
Relative Dose Intensity
Regimen Dose Index
, Revised Dose Information
Relative Drug Interaction
7. If a patient has an elevated serum creatinine level, how might this affect
the carboplatin dosing regimen?
The carboplatin dose will remain unchanged regardless of serum
creatinine levels.
The carboplatin dose may need to be reduced due to impaired
kidney function.
The carboplatin dose will be increased to compensate for the
elevated creatinine.
The patient will require additional hydration to increase the
carboplatin dose.
8. Before initiation of a chemotherapy infusion, a patient is administered
Dexamethasone and Diphenhydramine to reduce the incidence of
hypersensitivity reaction. Based on this information, which
chemotherapy drug is going to be infused?
Cisplatin
Cyclophosphamide
Any of these drugs, hypersensitivity is a common adverse effect
to all chemotherapy
5-Fluorouracil
Paclitaxel
9. Mr. Pros is experiencing mucositis. Which health teaching would be most
appropriate for this condition?
Eat a bland diet with low roughage and use a soft toothbrush
or plain water rinses for oral care.
, Increase intake of citrus-containing foods and beverages.
This adverse effect is expected and will disappear within a few
days.
10. Isotonic sodium thiosulfate is given when extravasation of this drug
occurs:
dactinomycin
doxorubicin
mechlorethamine
etoposide
11. Describe how the combination of Gabapentin and opioids can be
beneficial for patients with peripheral neuropathy.
The combination has no significant benefits over single-agent
therapy.
The combination is primarily for treating anxiety disorders.
The combination is used to prevent chemotherapy side effects.
The combination can provide enhanced pain relief by targeting
different pain pathways.
12. What is the recommended method to help reduce local discomfort
during chemotherapy treatment?
warm compress
cold compress
topical anesthetic
ice pack
13. Describe the implications of using vesicants in chemotherapy treatment.
WITH 100% ACCURATE ANSWERS
1. TW is a 62-year-old female recently diagnosed with lymphoma. She
received rituximab, cyclophosphamide, vincristine, doxorubicin, and
prednisone (RCHOP). She did not receive any GCSF after chemotherapy.
One week after her chemotherapy, she was admitted for febrile
neutropenia. The physician asks if it is okay for her to receive GCSF after
each chemotherapy. As the pharmacist, you recommend...
She should receive GCSF within 24 hours of completion of
chemotherapy
She should receive GCSF at least 24 hours after completing
chemotherapy
She should not receive GCSF
2. Which statement accurately describes the mechanism of action of
Cytotoxic Antibiotic Antineoplastic Drugs?
They bind to specific receptors on the cell membrane to induce
apoptosis.
They directly destroy cancer cells by causing cell lysis.
They disrupt DNA synthesis by inhibiting the formation of new
DNA strands.
They interact with DNA to create cross-links and strand breaks,
leading to cell death.
3. Describe the significance of monitoring LVEF in patients receiving
chemotherapy with pertuzumab and trastuzumab.
Monitoring LVEF is only necessary if the patient experiences
symptoms.
, Monitoring LVEF is crucial to assess the risk of cardiotoxicity
and to make informed decisions about continuing or
withholding treatment.
Monitoring LVEF is irrelevant for patients on chemotherapy.
Monitoring LVEF is only required before the first cycle of
chemotherapy.
4. If a hospital implements the NCCN Older Adult Oncology Guidelines,
what changes might they make to their chemotherapy treatment
protocols for older patients?
They may incorporate comprehensive geriatric assessments to
tailor treatment plans.
They may eliminate the use of chemotherapy for older patients.
They may reduce the number of chemotherapy sessions for all
patients.
They may only focus on younger patients' treatment protocols.
5. What are the key points to consider when managing combination
therapy in chemotherapy?
Cost of treatment, patient preference, and drug availability.
Patient age, drug interactions, and treatment duration.
Potential toxicity, monitoring guidelines, and significant signs
and symptoms.
Type of cancer, stage of disease, and patient demographics.
6. What does RDI stand for in the context of chemotherapy treatment?
Relative Dose Intensity
Regimen Dose Index
, Revised Dose Information
Relative Drug Interaction
7. If a patient has an elevated serum creatinine level, how might this affect
the carboplatin dosing regimen?
The carboplatin dose will remain unchanged regardless of serum
creatinine levels.
The carboplatin dose may need to be reduced due to impaired
kidney function.
The carboplatin dose will be increased to compensate for the
elevated creatinine.
The patient will require additional hydration to increase the
carboplatin dose.
8. Before initiation of a chemotherapy infusion, a patient is administered
Dexamethasone and Diphenhydramine to reduce the incidence of
hypersensitivity reaction. Based on this information, which
chemotherapy drug is going to be infused?
Cisplatin
Cyclophosphamide
Any of these drugs, hypersensitivity is a common adverse effect
to all chemotherapy
5-Fluorouracil
Paclitaxel
9. Mr. Pros is experiencing mucositis. Which health teaching would be most
appropriate for this condition?
Eat a bland diet with low roughage and use a soft toothbrush
or plain water rinses for oral care.
, Increase intake of citrus-containing foods and beverages.
This adverse effect is expected and will disappear within a few
days.
10. Isotonic sodium thiosulfate is given when extravasation of this drug
occurs:
dactinomycin
doxorubicin
mechlorethamine
etoposide
11. Describe how the combination of Gabapentin and opioids can be
beneficial for patients with peripheral neuropathy.
The combination has no significant benefits over single-agent
therapy.
The combination is primarily for treating anxiety disorders.
The combination is used to prevent chemotherapy side effects.
The combination can provide enhanced pain relief by targeting
different pain pathways.
12. What is the recommended method to help reduce local discomfort
during chemotherapy treatment?
warm compress
cold compress
topical anesthetic
ice pack
13. Describe the implications of using vesicants in chemotherapy treatment.
